Medical School |
Medical School, Shandong University, Jinan, Shandong, China |
|
1995 |
MD, MSci |
Graduate |
Baylor College of Medicine, Houston, TX |
|
2004 |
PhD |
Residency |
UT Southwestern Medical Center, Dallas, TX |
|
2010 |
Internal Medicine |
Fellowship |
UT Southwestern Medical Center, Dallas, TX |
|
2015 |
Cardiology |
|
Internal Medicine Board Certification |
2010 |
Internal Medicine Board Certification-Cardiovascular Diseases |
2015 |
|
Appointment Type |
Department |
Division |
Rank |
Primary |
Med - Cardiovascular Disease |
Med - Cardiovascular Disease |
Associate Professor |
Center |
Comprehensive Cardiovascular Ctr |
Comprehensive Cardiovascular Ctr |
Associate Professor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Associate Professor |
Center |
Ctr for Clinical & Translational Sci |
Ctr for Clinical & Translational Sci |
Associate Professor |
|
Publication |
PUBMEDID |
Zhao M, Nakada Y, Wei Y, Bian W, Chu Y, Borovjagin AV, Xie M, Zhu W, Nguyen T, Zhou Y, Serpooshan V, Walcott GP, Zhang J.Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction. Circulation. 2021 May 6. doi: 10.1161/CIRCULATIONAHA.120.049497. Online ahead of print. |
33951921 |
Latimer MN, Sonkar R, Mia S, Frayne IR, Carter KJ, Johnson CA, Rana S, Xie M, Rowe GC, Wende AR, Prabhu SD, Frank SJ, Rosiers CD, Chatham JC, Young ME. Branched chain amino acids selectively promote cardiac growth at the end of the awake period. J Mol Cell Cardiol. 2021 Apr 21;157:31-44. doi: 10.1016/j.yjmcc.2021.04.005. Online ahead of print. |
33894212 |
Ernst P, Chen K, Tang Y, Kim S, Guan J, He J, Xie M, Zhang JJ, Liu XM, Zhou L.Investigation into the difference in mitochondrial-cytosolic calcium coupling between adult cardiomyocyte and hiPSC-CM using a novel multifunctional genetic probe.Pflugers Arch. 2021 Mar;473(3):447-459. doi: 10.1007/s00424-021-02524-3. Epub 2021 Feb 15. |
33587181 |
J. Yang, J. He, M. Ismail, S. Tweeten, F. Zeng, L. Gao, S. Ballinger, M. Young, S.D. Prabhu, G.C. Rowe, J. Zhang, L. Zhou, M. Xie, HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injury, J Mol Cell Cardiol, 2019. 130: p. 36-48. |
30880250 |
Fiedler LR*, Chapman K*, Xie M*, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD.* These authors contributed equally to this work. MAP4K4 mediates human cardiac muscle cell death: Human pluripotent stem cell-derived cardiomyocytes for target validation and drug development. Cell Stem Cell, 2019. 24(4): p. 579-591 e12. |
30853557 |
Xie M, Tang Y, Hill JA. HDAC inhibition as a therapeutic strategy in myocardial ischemia/reperfusion injury. J Mol Cell Cardiol. 2019 Apr;129:188-192. |
30825484 |
Cheng M, Yang J, Zhao X, Zhang E, Zeng Q, Yu Y, Yang L, Wu B, Yi G, Mao X, Huang K, Dong N, Xie M, Limdi NA, Prabhu SD, Zhang J, Qin G. Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells. Nat Commun. 2019 Feb 27;10(1):959. |
30814518 |
Xie M, Kong Y, Tan W, May H, Battiprolu PK, Pedrozo Z, Wang Z, Morales C, Luo X, Cho G, Jiang N, Jessen ME, Warner JJ, Lavandero S, Gillette TG, Turer AT, Hill JA. (2014) HDAC Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy. Circulation.2014, Mar 11;129(10):1139-51. doi:10.1161/CIRCULATIONAHA.113.002416. Epub 2014 Jan 6. |
24396039 |
Xie M, Burchfield JS, Hill JA. Pathological ventricular remodeling: therapies: part 2 of 2. Circulation. 2013 Aug 27;128(9):1021-30. doi: 10.1161/CIRCULATIONAHA.113.001879. Review |
23979628 |
Burchfield JS, Xie M, Hill JA. Pathological ventricular remodeling: therapies: part 1 of 2. Circulation. 2013 Jul 23;128(4):388-400. doi: 10.1161/CIRCULATIONAHA.113.001878. Review |
23877061 |
Xie M, Hill JA. HDAC-dependent ventricular remodeling. Trends Cardiovasc Med. 2013 Aug;23(6):229-35. doi: 10.1016/j.tcm.2012.12.006. Epub 2013 Mar 15. Review |
23499301 |
Xie M, Morales CR, Lavandero S, Hill JA. Tuning flux: autophagy as a target of heart disease therapy. Curr Opin Cardiol. 2011 May;26(3):216-22. doi: 10.1097/HCO.0b013e328345980a. Review |
21415729 |
Greenblatt, M. B., Shim, J. H., Zou, W., Sitara, D., Schweitzer, M., Hu, D., Lotinun, S., Sano, Y., Baron, R., Park, J. M., Arthur, S., Xie, M., Schneider, M. D., Zhai, B., Gygi, S., Davis, R., and Glimcher, L. H. (2010) The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice, J Clin Invest 120, 2457-2473. |
20551513 |
Fan, Y., Yu, Y., Shi, Y., Sun, W., Xie, M., Ge, N., Mao, R., Chang, A., Xu, G., Schneider, M. D., Zhang, H., Fu, S., Qin, J., and Yang, J. (2010) Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation, J Biol Chem 285, 5347-5360. |
20038579 |
Shim, J. H., Greenblatt, M. B., Xie, M., Schneider, M. D., Zou, W., Zhai, B., Gygi, S., and Glimcher, L. H. (2009) TAK1 is an essential regulator of BMP signalling in cartilage, EMBO J 28, 2028-2041. |
19536134 |
Yu, Y., Ge, N., Xie, M., Sun, W., Burlingame, S., Pass, A. K., Nuchtern, J. G., Zhang, D., Fu, S., Schneider, M. D., Fan, J., and Yang, J. (2008) Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression, J Biol Chem 283, 24497-24505. |
18617512 |
Xie M, Zhang D, Dyck JR, Li Y, Zhang H, Morishima M, Mann DL, Taffet GE, Baldini A, Khoury DS, Schneider MD. Transforming growth factor beta-activated kinase-1 modulates the energy-sensor pathway for Wolff-Parkinson-White syndrome. Proc Natl Acad Sci USA. 2006 Nov 14;103(46):17378-17383. |
17085580 |
Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, et al. (2006) Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis, Proc Natl Acad Sci U S A 103, 14495-14500. |
16983089 |
Liu, H. H., Xie, M., Schneider, M. D., and Chen, Z. J. (2006) Essential role of TAK1 in thymocyte development and activation, Proc Natl Acad Sci U S A 103, 11677-11682. |
16857737 |
Wan, Y. Y., Chi, H., Xie, M., Schneider, M. D., and Flavell, R. A. (2006) The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function, Nat Immunol 7, 851-858. |
16799562 |
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