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Faculty Detail    
MD. Ph D.
Campus Address KAUL 742 Zip 0024
Phone  205-934-7308
Other websites

Graduate  University of Miyazaki, Miyazaki Medical College, Japan    2002  PhD 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Genetics   Genetics Research Div Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cellular and Molecular Biology Program 
Genetics and Genomic Sciences 

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research   Member    

Research/Clinical Interest
Cancer Cell Biology and Cancer Genetics
My research interest focuses on molecular biology of human diseases including cancer and chronic disease specifically in the molecular mechanisms of development and progression of cancer involved protein interactions in cell signaling pathways.

Selected Publications 
Publication PUBMEDID
Liu RH, Kurose T, Matsukura S. Oral nicotine administration decreases tumor necrosis factor-alpha expression in fat tissues in obese rats. Metabolism. 2001; 50(1):79-85.
2. Liu RH, Mizuta M, Kurose T, Matsukura S. Early events involved in the development of insulin resistance in Zucker fatty rat. Int J Obes Relat Metab Disord. 2002; 26(3):318-26.
3. Liu RH, Mizuta M, Matsukura S. Long-term oral nicotine administration reduces insulin resistance in obese rats. Eur J Pharmacol. 2003; 458(1-2): 227-34.
4. Liu RH, Mizuta M, Matsukura S. The expression and functional role of nicotinic acetylcholine receptors in rat adipocytes. J Pharmacol Exp Ther. 2004; 310(1): 52-8.
5. Saitoh Y, Liu R, Ueno H, Mizuta M, Nakazato M. Oral pioglitazone administration increases food intake through ghrelin-independent pathway in Zucker fatty rat. Diabetes Res Clin Pract. 2007; 77(3): 351-6.
6. Wang L, Lin S, Rammohan KW, Liu Z, Liu JQ, Liu RH, Guinther N, Lima J, Zhou Q, Wang T, Zheng X, Birmingham DJ, Rovin BH, Hebert LA, Wu Y, Lynn DJ, Cooke G, Yu CY, Zheng P, Liu Y. A dinucleotide deletion in CD24 confers protection against autoimmune diseases. PLoS Genetics, 2007; 3(4): 508-17.
7. Zuo T*, Liu RH*(* first co-author), Zhang H, Chang X, Liu Y, Wang L, Zheng P and Liu Y. FOXP3 is a novel transcription repressor for the breast cancer oncogene SKP2. J Clin Invest, 2007; 117(12): 3765-73.
8. Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med., 2008; 205(10): 2397-408.
9. Liu R, Wang L, Chen C, Liu Y, Zhou P, Wang Y, Wang X, Turnbull J, Minassian BA, Liu Y, Zheng P. Laforin negatively regulates cell cycle progression through GSK-3{beta} dependent mechanisms. Mol Cell Biol. 2008; 28 (23): 7236-44.
10. Liu R, Wang L, Chen C, Katoh H, Chen C, Zheng P, Liu Y. FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/4 association to the locus. Cancer Res. 2009; 69 (6): 2252-9.
11. Wang L*, Liu R*(* first co-author), Li W, Chen C, Katoh H, Chen GY, McNally B, Lin L, Zhou P, Zuo T, Cooney KA, Liu Y, Zheng P. Somatic Single-hits Inactivate the X-linked Tumor Suppressor FOXP3 in the Prostate. Cancer Cell, 2009; 16(4): 336-46.
12. Wang L, Liu R, Ribick M, Zheng P, Liu Y. FOXP3 as an X-linked tumor suppressor. Discov Med. 2010; 10(53): 322-8.
13. Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res. 2011; 71 (6): 2162-71.
14. Katoh H, Qin ZS, Liu R, Wang L, Li W, Li X, Wu L, Du Z, Lyons R, Liu CG, Liu X, Dou Y, Zheng P, Liu Y. FOXP3 Orchestrates H4K16 Acetylation and H3K4 Tri-Methylation for Gene Activation through Recruiting MOF and Displacing H3K4 Demethylase. Mol Cell. 2011; 44(5): 770-84.
15. Liu R, Kain M, Wang L. Inactivation of X-linked tumor suppressor genes in human cancer. Future Oncology. 2012; 8 (4): 463-81.
16. Wang L, Liu R, Li D, Lin S, Fang X, Backer G, Kain M, Rammoham K, Zheng P, Liu Y. A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis. Am J Transl Res. 2012; 4(3): 347-56.
17. Liu R, Li S, Yang WH, Wang L. IPEX Syndrome, FOXP3 and Cancer. Journal of Syndromes. 2013; 1(1):1-7.
18. Wang CM, Liu R, Wang L, Yang WH. Acidic residue Glu199 increases SUMOylation level of nuclear hormone receptor NR5A1. Int J Mol Sci. 2013; 14(11): 22331-45.
19. Liu R, Li S, Yang WH, Wang L. IPEX Syndrome, FOXP3 and Cancer. J Syndr. 2013 Jun;1(1). pii: 7.
20. Wang CM, Liu R, Wang L, Nascimento L, Brennan VC, Yang WH. SUMOylation of FOXM1B alters its transcriptional activity on regulation of MiR-200 family and JNK1 in MCF7 human breast cancer cells. Int J Mol Sci. 2014;15(6):10233-51.
21. Ye P, Liu Y, Chen C, Tang F, Wu Q, Wang X, Liu CG, Liu X, Liu R, Liu Y, Zheng P. An mTORC1-Mdm2-Drosha Axis for miRNA Biogenesis in Response to Glucose- and Amino Acid-Deprivation. Mol Cell. 2015 Feb 19;57(4):708-20.
22. Wang L*, Liu R*(* first co-author), Ye P, Wong C, Chen GY, Zhou P, Sakabe K, Zheng X, Wu W, Zhang P, Jiang T, Bassetti MF, Jube S, Sun Y, Zhang Y, Zheng P, Liu Y. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nature Communications, 2015 Jan 20; 6:5909.
23. Liu R*, Liu C, Chen D, Yang WH, Liu X, Liu CG, Dugas CM, Tang F, Zheng P, Liu Y, Wang L*. FOXP3 controls an miR-146/NFκB negative feedback loop that inhibits apoptosis in breast cancer cells. Cancer Res. 2015 Apr 15;75(8):1703-13.
24. Liu R*, Yi B, Wei S, Yang WH, Hart KM, Chauhan P, Zhang W, Mao X, Liu X, Liu CG, and Wang L*. FOXP3-miRNA146-NF-κB axis and therapy for precancerous lesion in prostate. Cancer Res. 2015 Apr 15;75(8):1714-24.
25. Zhang W, Yi B, Wang C, Chen D, Bae S, Wei S, Guo RJ, Lu C, Nguyen LLH, Yang WH, Lillard JW, Zhang X, Wang L, Liu R*. Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cells. Clin Cancer Res. 2015 Dec 28. pii: clincanres.1927.2015. [Epub ahead of print]