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Faculty Detail    
Name ANIL KUMAR CHALLA
 
Campus Address CH 464 Zip 1170
Phone  (205) 934-8308
E-mail  akchalla@uab.edu
Other websites Undergraduate Program in Genetics & Genomic Sciences
CURE with CRISPR-Cas9
Zebrafish Information Network
CRISPR course unleashes critical-thinking skills for UAB freshmen
     

Education
Undergraduate  Banaras Hindu University      BSc (Agricultural Sciences) 
Graduate  The Ohio State University      PhD (Molecular Genetics) 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Biology  Biology Professor Adjunct



Selected Publications 
Publication PUBMEDID
Identification and characterization of roundabout orthologs in zebrafish. Challa AK, Beattie CE, Seeger MA. Mech Dev. 2001 Mar;101(1-2):249-53.  11231085 
Robo3 isoforms have distinct roles during zebrafish development. Challa AK, McWhorter ML, Wang C, Seeger MA, Beattie CE. Mech Dev. 2005 Oct;122(10):1073-86.  16129585 
9-O-acetylation of exogenously added ganglioside GD3. The GD3 molecule induces its own O-acetylation machinery. Chen HY, Challa AK, Varki A. J Biol Chem. 2006 Mar 24;281(12):7825-33. Epub 2006 Jan 24.  16434401 
Caffeine-induced effects on heart rate in zebrafish embryos and possible mechanisms of action: an effective system for experiments in chemical biology. Rana N, Moond M, Marthi A, Bapatla S, Sarvepalli T, Chatti K, Challa AK. Zebrafish. 2010 Mar;7(1):69-81. doi: 10.1089/zeb.2009.0631.  20415645 
Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology. Challa AK, Chatti K. Zebrafish. 2013 Sep;10(3):264-74. doi: 10.1089/zeb.2012.0781. Epub 2012 Dec 12.  23234507 
Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes. Challa AK, Boitet ER, Turner AN, Johnson LW, Kennedy D, Downs ER, Hymel KM, Gross AK, Kesterson RA. PLoS One. 2016 May 25;11(5):e0155812. doi: 10.1371/journal.pone.0155812. eCollection 2016.  27224051 
Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. Lewis WR, Malarkey EB, Tritschler D, Bower R, Pasek RC, Porath JD, Birket SE, Saunier S, Antignac C, Knowles MR, Leigh MW, Zariwala MA, Challa AK, Kesterson RA, Rowe SM, Drummond IA, Parant JM, Hildebrandt F, Porter ME, Yoder BK, Berbari NF. PLoS Genet. 2016 Jul 29;12(7):e1006220. doi: 10.1371/journal.pgen.1006220. eCollection 2016 Jul.  27472056 
Increased trabecular bone and improved biomechanics in an osteocalcin null rat model created by CRISPR/Cas9 technology. Lambert LJ, Challa AK, Niu A, Zhou L, Tucholski J, Johnson MS, Nagy TR, Eberhardt AW, Estep PN, Kesterson RA, Grams JM. Dis Model Mech. 2016 Jul 28. pii: dmm.025247. [Epub ahead of print]  27483347  

Keywords
Gene knockout/editing, CRISPR-Cas9, zebrafish, mouse, rat, Course-based Undergraduate Research Experiences (CUREs), Biology Education Research.