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Faculty Detail    
Name SUMANTH D PRABHU
Director, Division of Cardiovascular Disease
Director, Comprehensive Cardiovascular Center
Mary G. Waters Chair of Cardiovascular Medicine		  
Campus Address THT 311 Zip 0006
Phone
E-mail
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Education
Medical School  Jefferson Medical College    1985  MD 
Residency  University of Pittsburgh    1988  Resident, Internal Medicine 
Fellowship  University of Pittsburgh    1989  Physician Investigator Research Fellowship 
Fellowship  University of Texas Health Science Center at San Antonio    1992  Cardiovascular Disease Fellowship 


Faculty Appointment(s)
Appointment Type Department Division Rank
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor Adjunct
Center  Neurology   Evelyn F. McKnight Brain Institute Professor Adjunct
Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Professor Adjunct
Center  Biomedical Engineering  Biomatrix Eng Regen Med (BERM) Ctr Professor Adjunct
Primary  Medicine  Med - Cardiovascular Disease Professor Adjunct
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Secondary  Biomedical Engineering  Biomedical Engineering Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Medical Scientist Training Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Prabhu received a BS degree in Science from Penn State University and his MD degree from Jefferson Medical College in Philadelphia. He did internal medicine residency at the University of Pittsburgh and a cardiology fellowship at the University of Texas Health Science Center at San Antonio. He was a cardiology faculty there as well as at the University of Louisville, before his arrival to UAB as Director of the Division of Cardiovascular Disease. He is also Director of the UAB Comprehensive Cardiovascular Center. Dr. Prabhu serves as a Consulting Editor of Circulation Research and is a member of the American Society for Clinical Investigation.

Society Memberships
Organization Name Position Held Org Link
American College of Cardiology  Fellow   
American Heart Association  Fellow   
American Society for Clinical Investigation  Member  http://www.the-asci.org/controllers/asci/AsciProfileController.php?pid=500719 
 



Research/Clinical Interest
Title
Mechanisms of cardiac remodeling and repair in heart failure
Description
We are actively studying fundamental mechanisms of pathological remodeling in the failing heart, with a particular focus on inflammatory pathways (tumor necrosis factor, nuclear factor-kappaB) and immune cell types (e.g., macrophages). We are also interested in the interplay between inflammatory signaling and cardiac stem cell-mediated repair in the failing heart. Our clinical studies examine the effects of mechanical support (ventricular assist devices) on forward and reverse remodeling in human heart failure.

Selected Publications 
Publication PUBMEDID
Characteristics and outcomes of patients with advanced chronic systolic heart failure receiving care at the Veterans Affairs versus other hospitals: insights from the Beta-blocker Evaluation of Survival Trial (BEST).
Jones LG, Sin MK, Hage FG, Kheirbek RE, Morgan CJ, Zile MR, Wu WC, Deedwania P, Fonarow GC, Aronow WS, Prabhu SD, Fletcher RD, Ahmed A, Allman RM.
Circ Heart Fail. 2015 Jan;8(1):17-24. doi: 10.1161/CIRCHEARTFAILURE.114.001300. Epub 2014 Dec 5. 		 25480782 
Beta-blocker Use and 30-day All-cause Readmission in Medicare Beneficiaries with Systolic Heart Failure.
Bhatia V, Bajaj NS, Sanam K, Hashim T, Morgan CJ, Prabhu SD, Fonarow GC, Deedwania P, Butler J, Carson P, Love TE, Kheirbek R, Aronow WS, Anker SD, Waagstein F, Fletcher R, Allman RM, Ahmed A.
Am J Med. 2015 Jul;128(7):715-21. doi: 10.1016/j.amjmed.2014.11.036. Epub 2014 Dec 30. 		 25554369 
Pretransplant coagulopathy and in-hospital outcomes among heart transplant recipients: a propensity-matched nationwide inpatient sample study.
Mujib M, Khanna N, Mazumder NK, Aronow WS, Kolte D, Khera S, Palaniswamy C, Jain D, Lanier GM, Sule S, Ahmed A, Levy WC, Prabhu SD, Cooper HA, Panza JA, Gass AL, Fonarow GC.
Clin Cardiol. 2015 May;38(5):300-8. doi: 10.1002/clc.22391. Epub 2015 Feb 13. 		 25684174  
Reply: Upgrade ambulatory extra-aortic counterpulsation to full-support LVAD.
Abraham WT, Aggarwal S, Prabhu SD, Cecere R, Pamboukian SV, Bank AJ, Sun B, Pae WE Jr, Hayward CS, McCarthy PM, Peters WS, Verta P, Slaughter MS; C-Pulse Trial Study Group.
JACC Heart Fail. 2015 Apr;3(4):343-4. doi: 10.1016/j.jchf.2014.12.011. No abstract available. 		 25858795 
Glutathione S-transferase P protects against cyclophosphamide-induced cardiotoxicity in mice.
Conklin DJ, Haberzettl P, Jagatheesan G, Baba S, Merchant ML, Prough RA, Williams JD, Prabhu SD, Bhatnagar A.
Toxicol Appl Pharmacol. 2015 Jun 1;285(2):136-48. doi: 10.1016/j.taap.2015.03.029. Epub 2015 Apr 10. 		 25868843 
Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function.
Kain V, Ingle KA, Colas RA, Dalli J, Prabhu SD, Serhan CN, Joshi M, Halade GV.
J Mol Cell Cardiol. 2015 Jul;84:24-35. doi: 10.1016/j.yjmcc.2015.04.003. Epub 2015 Apr 11. 		 25870158 
Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury.
Conklin DJ, Guo Y, Jagatheesan G, Kilfoil PJ, Haberzettl P, Hill BG, Baba SP, Guo L, Wetzelberger K, Obal D, Rokosh DG, Prough RA, Prabhu SD, Velayutham M, Zweier JL, Hoetker JD, Riggs DW, Srivastava S, Bolli R, Bhatnagar A.
Circ Res. 2015 Aug 14;117(5):437-49. doi: 10.1161/CIRCRESAHA.114.305518. Epub 2015 Jul 13. 		 26169370 
Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells.
DeJarnett N, Yeager R, Conklin DJ, Lee J, O'Toole TE, McCracken J, Abplanalp W, Srivastava S, Riggs DW, Hamzeh I, Wagner S, Chugh A, DeFilippis A, Ciszewski T, Wyatt B, Becher C, Higdon D, Ramos KS, Tollerud DJ, Myers JA, Rai SN, Shah J, Zafar N, Krishnasamy SS, Prabhu SD, Bhatnagar A.
Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2468-77. doi: 10.1161/ATVBAHA.115.305724. Epub 2015 Aug 20. 		 26293462 
Cardiomyocyte specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response and impaired resolution of inflammation.
Ingle KA, Kain V, Goel M, Prabhu SD, Young ME, Halade GV.
Am J Physiol Heart Circ Physiol. 2015 Oct 2:ajpheart.00608.2015. doi: 10.1152/ajpheart.00608.2015. [Epub ahead of print] 		 26432841 
O-GlcNAcylation Negatively Regulates Cardiomyogenic Fate in Adult Mouse Cardiac Mesenchymal Stromal Cells.
Zafir A, Bradley JA, Long BW, Muthusamy S, Li Q, Hill BG, Wysoczynski M, Prabhu SD, Bhatnagar A, Bolli R, Jones SP.
PLoS One. 2015 Nov 13;10(11):e0142939. doi: 10.1371/journal.pone.0142939. eCollection 2015. 		 26565625  
 

Keywords
heart failure, ventricular remodeling, stem cells, inflammation, cardiac function