Medical Scientist Training Program    Back to Main

Faculty Detail    
Campus Address WT 287C
Phone  (205) 934-9925
Other websites

Undergraduate  University of Waterloo, Canada    1975  BSc (Honors, Biology & Chemistry) 
Graduate  University of Toronto, Canada    1988  PhD 
Fellowship  Washington University    1990  Post Doctoral Fellowship in Clinical Chemistry and Diabetes Research 

DABCC   1997 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Laboratory Medicine Professor Emeritus

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY University of Waterloo, Canada BSc 1975 Biology & Chemistry University of Toronto, Canada MSc & PhD 1982 & 1988 Clinical Biochemistry Washington University, St. Louis, MO Post-doc 1988-90 Diabetes Univ. of Alabama at Birmingham, Birmingham, AL Post-doc 1990-91 Diabetes AWARDS/HONORS 1982 Open Masters Fellowship, University of Toronto 1984 Open Doctoral Fellowship, University of Toronto 1985 Mitchell Scholarship, Life Sciences Department, University of Toronto 1986 Med-Chem Award, Canadian Society of Clinical Chemists 1988-1990 Canadian Diabetes Association Individual Research, Post Doctoral Fellowship 1988-1991 Individual Research Postdoctoral Fellowship, Canadian Diabetes Association 1989 Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists 1999 Fellow of the National Academy of Clinical Biochemistry 2000 Editorial Board Laboratory Medicine 2008 Sr. Associate Editor for Laboratory Investigation

Society Memberships
Organization Name Position Held Org Link
ACS  President   
USCAP  Senior Associate Editor for Laboratory Investigation   

Research/Clinical Interest
Translational research
My primary area of interest is in clinical translational research involving oxidative stress and clinical chemistry. In particular I am interested in bringing assays for oxidative stress into the clinical lab. To this end I am participating in a project to establish a robust assay that describes mitochondrial bioenergetics.

Selected Publications 
Publication PUBMEDID
Shen M-C, Zhao X, Siegal GP, Desmond R, Hardy RW. Dietary Stearic Acid leads to a Reduction of Visceral Adipose Tissue in Athymic Nude Mice. PLoS One 2014, 9:e104083  4164353 
Zhao X, Rezonzew G, Wang D, Siegal GP, Hardy RW. Diet Modulation is an Effective Complementary Agent in Preventing and Treating Breast Cancer Lung Metastasis. Clinical & Experimental Metastasis 2014;31:625-638.  24832758 
Chacko B, Kramer PA, Ravi1 S, Benavides GA, Mitchell T, Dranka BP, Ferrick D, Singa AK, Ballinger SW, Bailey SM, Hardy RW, Zhang J, Zhi D, Darley-Usmar VM. The Bioenergetic Health Index: A New Concept in Mitochondrial Translational Research. Clinical Science 2014;127:367-373.
Chacko B, Kramer P, Ravi S, Hardy RW, Johnson M, Ballinger S, Darley-Usmar V. Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes and neutrophils and the oxidative burst from human blood. Laboratory Investigation 2013;93:690-700.  3674307 
Li C, Zhao X, Toline EC, Siegal GP, Evans LM, Ibrahim-Hashim A, Desmond RA, Hardy RW. Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate. Carcinogenesis. 2011;32:1251–1258.  3149204 
Evans LM, Toline EC, Desmond R, Siegal GP, Ibrahim-Hashim A, Hardy RW. Dietary stearate reduces breast cancer metastasis burden in athymic nude mice. Clin Exp Metastasis. 2009;26:415-424.   2946234 
Evans LM, Cowey SL, Siegal GP, Hardy RW. Stearate preferentially induces apoptosis in human breast cancer cells. Nutr Cancer. 2009;61:746–753.   2946230 
Byon CH, Hardy RW, Ren C, Ponnazhagan S, Welch DR, McDonald JM, Chen Y. Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4. Lab Invest. 2009;89:1221–1228.  2905319 
Deng Z-b, Poliakov A, Clements R, Liu C, Liu Y, Wang J, Xiang X, Garvey T, Michalek S, Grizzle WE, Hardy RW, Mobley J, Zhang H-G. Adipose tissue exosome-like vesicles mediate activation of macrophage induced insulin resistance. Diabetes. 2009;58:2498–2505.  2768161 
Ji S, Hardy RW, Wood PA. Transgenic expression of n-3 fatty acid desaturase (fat-1) in C57/BL6 mice: effects on glucose homeostasis and body weight. J Cell Biochem. 2009;107:809-817.   2763528 
Azrad M, Zhang K, Vollmer RT, Madden J, Polascik TJ, Snyder DC, Ruffin MT, Robertson CN, Moul JW, Brenner D, Hardy RW, Wendy Demark-Wahnefried W. Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: A relationship which may be modified by genetic variation in ALA metabolism PLoS One 2012;7:e53104.  23285256 
Williams V, Martin R, Franklin JL, Hardy RW, Messina JL. Injury-Induced Insulin Resistance in Adipose Tissue. Biochemical and Biophysical Research Communications 2012;421:442-448.  22521887 
Cowey S, Szafran AA, Kappes J, Zinn KR, Siegal GP, Desmond RA, Kim H, Evans L, Hardy RW. Breast cancer metastasis to bone: evaluation of bioluminescent imaging and microSPECT/CT for detecting bone metastasis in immunodeficient mice. Clin Exp Metastasis. 2007;24:389-401.   17541709 
Cowey S, Hardy RW. The metabolic syndrome: a high risk state for cancer? Am J Pathol. 2006;169:1505-1522.   17071576 
Zhao H, Hardy RW. Long chain saturated fatty acids induce annexin II translocation to detergent resistant membranes. Biochem J. 2004;381:463-469.  15099193 

oxidative stress, cancer, insulin resistance