Undergraduate |
Tianjin University |
|
1997 |
BS |
Graduate |
Tianjin University |
|
2000 |
MS |
Graduate |
Case Western Reserve University |
|
2006 |
PhD |
|
Appointment Type |
Department |
Division |
Rank |
Center |
|
|
Associate Professor |
Secondary |
Biomedical Engineering |
Biomedical Engineering |
Assistant Professor |
Center |
Comprehensive Cardiovascular Ctr |
Comprehensive Cardiovascular Ctr |
Associate Professor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Associate Professor |
Primary |
Medicine |
Med - Cardiovascular Disease |
Associate Professor |
Center |
Nutrition Sciences |
Nutrition Obesity Res Ctr (NORC) |
Associate Professor |
|
Cancer Biology |
Cell, Molecular, & Developmental Biology |
Genetics, Genomics and Bioinformatics |
Immunology |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Liu J, Wang P, Zou L, Qu J, Litovsky SH, Umeda PK, Zhou L, Chatham JC, Marsh SA, Dell'Italia LJ, Lloyd SG. High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats. Am J Physiol Heart Circ Physiol. 2014 15;307(4):H598-608. |
24929857 |
Ma C, Kojimab K, Xu N, Mobley J, Zhou L, Yang ST, and Liu XM. Comparative proteomics analysis of high n-butanol producing metabolically engineered Clostridium tyrobutyricum. J Biotechnol. In press |
25449011 |
Zhou L, Xu N, Sun Y, Liu XM. Targeted biopharmaceuticals for cancer treatment. Cancer Letters, 2014, 1;352(2):145-51 |
25016064 |
Zhou L*. Optogenetic pacing for resynchronization therapy of heart failure. Austin J Biomed Eng. 2014;1(3):2 |
|
Li Q, Pogwizd SM, Prabhu SD, Zhou L*. Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in Guinea pig cardiomyocytes. PLoS One. 2014 10;9(4):e93928 |
24722410 |
Collins HE, He L, Zou L, Qu J, Zhou L, Litovsky SH, Yang Q, Young ME, Marchase RB, Chatham JC. Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function. Am J Physiol Heart Circ Physiol. 2014 15;306(8):H1231-9. |
24585777 |
Zhou L, Solhjoo S, Millare B, Plank G, Abraham MR, Cortassa S, Trayanova N, O'Rourke B. Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis. Circ Arrhythm Electrophysiol. 2014 7(1):143-51. |
24382411 |
Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI,Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, Kass DA, Mahaney JE, Paolocci N. HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Antioxid Redox Signal. 2013 10;19(11):1185-97. |
23919584 |
Zhou L and O’Rourke B. "Cardiac mitochondrial network excitability: insights from computational analysis". Am J Physiol Heart Circ Physiol 302: H2178-89, 2012. |
22427517 |
Zhou L, Aon MA, Ting Liu, and O’Rourke B. “Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.” J Mol Cell Cardiol. 2011 Nov;51(5):632-9 (Highlighted Article). |
21645518 |
Zhou L, Aon M, Tabish A, Cortassa S, Winslow R and O’Rourke B. “A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.” PLoS Comput Biol 6(1): e1000657. doi:10.1371/journal.pcbi.1000657, 2010. |
20126535 |
Zhou L, Cortassa S, Wei AC, Aon MA, Winslow R and O’Rourke B. “Modeling cardiac action potential shortening driven by ROS-Induced mitochondrial oscillations in guinea pig cardiomyocyte.” Biophysical J, 97(7):1843-1853, 2009. |
19804714 |
Zhou L, Huang H, McElfresh TA, Prosdocimo T, and Stanley WC. “Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia.” Am J Physiol Heart Circ Physiol, 295(3):H939-45, 2008 |
18660443 |
Plank G, Zhou L, Greenstein J, Cortassa S, Winslow R, O’Rourke B and Trayanova N. “From mitochondrial ionic channels to arrhythmias in the heart.” Philos Transact A Math Phys Eng Sci, 366(1879):3381-409, 2008. |
18603526 |
Lu M, Zhou L, Stanley WC, Cabrera ME, Saidel GM, and Yu X. “Analysis and prediction of cardiac metabolism and transport: role of malate-aspartate shuttle.” J of Theor Bio, 254(2):466-75, 2008. |
18603266 |
Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, and Stanley WC. “Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.” Am J Physiol Heart Circ Physiol, 294(2): H954-60, 2008. |
18083904 |
Zhou L, Cabrera ME, Huang H, Yuan CL, Monika DK, Sharma N, Bian F, and Stanley WC. “Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation.” J Physiol (Lond), 579, 811-21, 2007 |
17185335 |
Zhou L, Cabrera ME, Okere IC, Sharma N, and Stanley WC. “Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies.” Am J Physiol Heart Circ Physiol, 291: H1036-H1046, 2006. |
16603683 |
Zhou L, Stanley WC, Saidel GM, Yu X, and Cabrera ME. “Lactate production at the onset of ischemia is regulated by glycolysis and the transfer of NADH into mitochondria independent of mitochondrial NADH/NAD+: insights from in silico studies.” J Physiol (Lond), 569: 925-937, 2005. |
16223766 |
Zhou L, Salem JE, Saidel GM, Stanley WC, and Cabrera ME. “Mechanistic model of cardiac energy metabolism predicts localization of glycosis to cytosolic sub-domain during ischemia.” Am J Physiol Heart Circ Physiol, 288: H2400-H2411, 2005. |
15681693 |
Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L and O’Rourke B. “From mitochondrial dynamics to arrhythmias.” Int J Biochem Cell Biol. 41(10): 1940-1948, 2009. |
19703656 |
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