Back to Main

Faculty Detail    
Campus Address THT 760 Zip 0000
Phone  (205) 934-5486
Other websites

Undergraduate  Lebanon Valley College, Annville PA      B.S. 
Graduate  Wake Forest University      Masters in Anthropology 
Residency  Duke University       General Surgery Residency 
Residency  University of Michigan       Thoracic Surgery Residency 
Fellowship  Duke University       Molecular Genetics, Transplantation, Thoracic Transplantation, Mechanical Circulatory Support  
Medical School  Duke University    1992  M.D. 

American Board Thoracic Surgery (June 2003, recertification December 2012, #6794)  2012 
American Board of Surgery (April 2000, recertification December 2012, #45097)  2012 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Surgery   Surgery - Cardiovascular/Thoracic Professor

Biographical Sketch 
Charles Hoopes, M.D., joined the Department of Surgery in 2015 serving as the chief of the Section of Thoracic Transplantation, where he leads efforts in heart and lung transplantation as well as artificial heart and lung devices. Hoopes came to UAB from the University of Kentucky where he was Director of the Transplant Center and section chief of Cardiopulmonary Transplantation. He was an Associate Professor of Surgery and Director of the cardiopulmonary transplant programs at the University of California San Francisco from 2001 to 2010.

Society Memberships
Organization Name Position Held Org Link
American College of Chest Physicians     
American College of Surgeons     
American Society of Transplant Surgeons     
Society of Thoracic Surgeons,      
Southern Thoracic Surgical Association     
Western Thoracic Surgical Association     

Research/Clinical Interest
Heart and lung transplantation, Mechanical Circulatory Support/VADs

Selected Publications 
Publication PUBMEDID
Hart JD, Lutz CT, Jennings CD, May JR, Nelson K, Jacobs S, Hoopes C. Falsely incompatible B-cell flow cytometry crossmatch after pronase treatment: a case report. Transplant Proc. 2015 Apr;47(3):831-3. doi: 10.1016/j.transproceed.2014.12.022.  25891741 
Rajagopalan N, Guglin M, Hoopes C. Short-term mechanical circulatory support: the problem of the uninsured. J Am Coll Cardiol. 2015 Mar 17;65(10):1062-3. doi: 10.1016/j.jacc.2014.11.063  25766959 
Rajagopalan N, Guglin M, Hoopes C. Role of left ventricular assist devices in assessment of patients for combined heart–kidney transplantation. Am J Transplant. 2014 Aug;14(8):1946-7.  25041558  
Kern RM, Seethamraju H, Blanc PD, Sinha N, Loebe M, Golden J, Kukreja J, Scheinin S, Hays S, Kleinhenz ME, Leard L, Hoopes C, Singer JP. The feasibility of lung transplantation in HIV-seropositive patients. Ann Am Thorac Soc. 2014 Jul;11(6):882-9. doi: 10.1513/AnnalsATS.201402-083OC  24964265 
Rajagopalan N, Yanagida R, Hoopes C. Insertion of Impella 5.0 to improve candidacy for HeartMate II left ventricular assist device placement. J Invasive Cardiol. 2014 Apr;26(4):E40-1.  24717279  
Haynes P, Nava KE, Lawson BA, Chung CS, Mitov MI, Campbell SG, Stromberg AJ, Sadayappan S, Bonnell MR, Hoopes CW, Campbell KS. Transmural heterogeneity of cellular level power output is reduced in human heart failure. J Mol Cell Cardiol. 2014 Jul;72:1-8. doi: 10.1016/j.yjmcc.2014.02.008. Epub 2014 Feb 20. PubMed PMID: 24560668; PubMed Central PMCID: PMC4037376  24560668 
Diaz-Guzman E, Zwischenberger JB, Thannickal VJ, Hoopes CW. Extracorporeal membrane oxygenation for acute respiratory failure in adults: the need for pulmonary INTERMACS. Am J Respir Crit Care Med. 2014 Dec 1;190(11):1321-2. doi:
10.1164/rccm.201408-1569LE. PubMed PMID: 25436785 
Rajagopalan N, Booth DC, Diaz-Guzman E, Hoopes C. Successful ventricular assist device placement in transposition of the great arteries with pulmonary hypertension. Ann Thorac Surg. 2013 Feb;95(2):e47. doi: 10.1016/j.athoracsur.2012.08.062  23336917 
Snell GI, Westall GP, Levvey BJ, Jaksch P, Keshavjee S, Hoopes CW, Ahya V, Mehta A, Trulock EP 3rd; ATG Study Investigators
A randomized, double-blind, placebo-controlled, multicenter study of rabbit ATG in the prophylaxis of acute rejection in lung transplantation. Am J Transplant. 2014 May;14(5):1191-8. doi: 10.1111/ajt.12663. Epub 2014 Mar 11 
Rajagopalan N, Hoopes CW, Rosenau J. Hepatitis C virus infection in heart transplantation: is ventricular assist device therapy an option? Transplantation. 2013 Aug 27;96(4):e23-4. doi: 10.1097/TP.0b013e31829c24a6.  23958885 
Sottile PD, Iturbe D, Katsumoto TR, Connolly MK, Collard HR, Leard LA, Hays S, Golden JA, Hoopes C, Kukreja J, Singer JP. Outcomes in systemic sclerosis-related lung disease after lung transplantation. Transplantation. 2013 Apr 15;95(7):975-80. doi: 10.1097/TP.0b013e3182845f23  23545509 
Hoopes CW, Kukreja J, Golden J, Davenport DL, Diaz-Guzman E, Zwischenberger JB. Extracorporeal membrane oxygenation as a bridge to pulmonary transplantation. J Thorac Cardiovasc Surg. 2013 Mar;145(3):862-7; discussion 867-8. doi: 10.1016/j.jtcvs.2012.12.022. Epub 2013 Jan 11.  23312979 
Winkler MA, von Herrmann PF, Brooks MA, Hoopes CW, Attili A, Sorrell VL. Synthetic ECG-gated cardiac computed tomography for in vivo imaging of the temporary total artificial heart. Circulation. 2013 Jan 1;127(1):e4-5. doi: 10.1161/CIRCULATIONAHA.112.130138  23283866 
Diaz-Guzman E, Hoopes CW, Zwischenberger JB. The evolution of extracorporeal life support as a bridge to lung transplantation. ASAIO J. 2013 Jan-Feb;59(1):3-10. doi: 10.1097/MAT.0b013e31827461c2  23271390 
Hoopes CW, Gurley JC, Zwischenberger JB, Diaz-Guzman E. Mechanical support for pulmonary veno-occlusive disease: combined atrial septostomy and venovenous extracorporeal membrane oxygenation. Semin Thorac Cardiovasc Surg. 2012 Autumn;24(3):232-4. doi: 10.1053/j.semtcvs.2012.03.003  23200082  
Malik A, Hsu JC, Hoopes C, Itinarelli G, Marcus GM. Elevated pulmonary artery systolic pressures are associated with a lower risk of atrial fibrillation following lung transplantation. J Electrocardiol. 2013 Jan-Feb;46(1):38-42. doi: 10.1016/j.jelectrocard.2012.07.014. Epub 2012 Sep 19  22999321 
Urisman A, Leard LE, Nathan M, Elicker BM, Hoopes C, Kukreja J, Jones KD. Rapidly progressive pulmonary venoocclusive disease in young women taking oral contraceptives. J Heart Lung Transplant. 2012 Sep;31(9):1031-6. doi: 10.1016/j.healun.2012.05.007  22884388 
Rajagopalan N, Hoopes C. Renal failure following ventricular assist device placement. J Am Coll Cardiol. 2012 Jun 12;59(24):2220; author reply p. 2220. doi: 10.1016/j.jacc.2012.01.062  22676945 
Hayes D Jr, Diaz-Guzman E, Davenport DL, Zwischenberger JB, Khosravi M, Absher KJ, Hoopes C. Lung transplantation in patients with coal workers' pneumoconiosis. Clin Transplant. 2012 Jul-Aug;26(4):629-34. doi: 10.1111/j.1399-0012.2011.01590.x. Epub 2012 Feb 23.  22360577  
Diaz-Guzman E, Neltner JM, Hoopes C. Organ donation and Moyamoya disease. Am J Transplant. 2012 May;12(5):1353-5. doi: 10.1111/j.1600-6143.2011.03934.x. Epub 2012 Feb 2.  22299649  
Watkins KD, Boettger RF, Hanger KM, Leard LE, Golden JA, Hoopes CW, Singer JP. Use of sublingual tacrolimus in lung transplant recipients. J Heart Lung Transplant. 2012 Feb;31(2):127-32. doi: 10.1016/j.healun.2011.10.015. Epub 2011 Dec 16.  22177691 
Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw RM. BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart Rhythm. 2012 May;9(5):812-20. doi: 10.1016/j.hrthm.2011.11.055. Epub 2011 Dec 2  22138472 
Hayes D Jr, Kukreja J, Tobias JD, Ballard HO, Hoopes C. Ambulatory venovenous extracorporeal respiratory support as a bridge for cystic fibrosis patients to emergent lung transplantation. J Cyst Fibros. 2012 Jan;11(1):40-5. doi: 10.1016/j.jcf.2011.07.009. Epub 2011 Oct 26  22035707 
Singer JP, Blanc PD, Hoopes C, Golden JA, Koff JL, Leard LE, Cheng S, Chen H. The impact of pretransplant mechanical ventilation on short- and long-term survival after lung transplantation. Am J Transplant. 2011 Oct;11(10):2197-204. doi: 10.1111/j.1600-6143.2011.03684.x. Epub 2011 Aug 10  21831157 
Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Jul;301(1):L71-8. doi: 10.1152/ajplung.00212.2010. Epub 2011 Apr 15  21498628 
Azadani PN, Kumar UN, Yang Y, Scheinman MM, Hoopes CW, Marcus GM, Rifkin C, Olgin JE, Lee BK. Frequency of atrial flutter after adult lung transplantation. Am J Cardiol. 2011 Mar 15;107(6):922-6. doi: 10.1016/j.amjcard.2010.10.076. Epub 2011 Jan 19.  21247524 
Singer JP, Huang MY, Hui C, Blanc PD, Boettger RF, Golden J, Watkins K, Hoopes C, Leard LE. Supratherapeutic anticoagulation from low-molecular-weight heparin in lung transplant recipients. J Heart Lung Transplant. 2010 Sep;29(9):1009-13. doi: 10.1016/j.healun.2010.04.018. Epub 2010 Jun 8  20627627 
Jensen BC, Swigart PM, De Marco T, Hoopes C, Simpson PC. {alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium. Circ Heart Fail. 2009 Nov;2(6):654-63. doi: 10.1161/CIRCHEARTFAILURE.108.846212. Epub 2009 Aug 6  19919991  
Jensen BC, Swigart PM, Laden ME, DeMarco T, Hoopes C, Simpson PC. The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries. J Am Coll Cardiol. 2009 Sep 22;54(13):1137-45. doi: 10.1016/j.jacc.2009.05.056  19761933  
Chen H, Shiboski SC, Golden JA, Gould MK, Hays SR, Hoopes CW, De Marco. Impact of the lung allocation score on lung transplantation for pulmonary arterial hypertension. Am J Respir Crit Care Med. 2009 Sep 1;180(5):468-74. doi: 10.1164/rccm.200810-1603OC. Epub 2009 Jun 11  19520906 
Sweet MP, Patti MG, Leard LE, Golden JA, Hays SR, Hoopes C, Theodore PR. Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation. J Thorac Cardiovasc Surg. 2007 Apr;133(4):1078-84. Epub 2007 Feb 22  17382656 
Sweet MP, Herbella FA, Leard L, Hoopes C, Golden J, Hays S, Patti MG. The prevalence of distal and proximal gastroesophageal reflux in patients awaiting lung transplantation. Ann Surg. 2006 Oct;244(4):491-7.  16998357