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Faculty Detail    
Charles B. Ireland Professor & Vice Chair for Research
Campus Address SC 1026 Zip 0017
Phone  (205) 975-9295
Other websites UAB Mood Disorders Program

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Psychiatry   Psych - Behavioral Neurobiology Professor
Secondary  Huntsville Medical Campus-General  Huntsville Med-Psychiatry Pgm Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Professor
Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Biographical Sketch 
Dr. Shelton attended medical school at the University of Louisville in Kentucky. He, then, travelled to Boston, MA, where he became a resident and, then, Chief Resident at the Massachusetts Mental Health Center (now the Longwood Program), a teaching hospital of the Harvard Medical School. After residency, he was a research fellow at the National Institutes of Mental Health Intramural Program in Washington, D.C. before entering the faculty at Vanderbilt University in 1985. There he rose through the ranks to become the James G. Blakemore Research Professor and Vice Chair for Clinical Research in the Department of Psychiatry. He also became a professor in the Departments of Psychology and Pharmacology. Dr. Shelton joined the faculty of the Department of Psychiatry and Behavioral Neurobiology at the University of Alabama at Birmingham in February, 2012 as the Charles Byron Ireland Professor, Vice Chair for Research, and head of a newly formed Mood Disorders Research Center.

Society Memberships
Organization Name Position Held Org Link
American College of Neuropsychopharmacology  Member 
American Medical Association  Member 
American Psychiatric Association  Member 
Society of Biological Psychiatry  Member 

Research/Clinical Interest
Mood Disorders
Clinical Interests: Depression and Bipolar Disorder Dr. Shelton’s clinical specialization is adult patients with mood disorders, including depression and bipolar disorder. Research Interests: Dr. Shelton’s research is on the causes and treatments of depression and bipolar disorder. He has a wide range of research activities, ranging from basic laboratory science to translational research linking lab to the clinic, to clinical investigations of new treatments for these common and serious conditions. The thrust of the program is experimental therapeutics – the search for new and better treatments.

Selected Publications 
Publication PUBMEDID
Garbett K.A., Vereczkei A., Kalman S., Taylor W., Faludi G., Korade Z., Shelton R.C., Mirnics K. Coordinated mRNA/miRNA changes in fibroblast of patients with major depression. Biological Psychiatry pii: S0006-3223(14)00376-X. doi: 10.1016/j.biopsych.2014.05.015. [Epub ahead of print]  25016317 
Hollon S.D., DeRubeis R.J., Fawcett J., Amsterdam J.D., Shelton R.C., Zajecka J., Young P.R., Gallop R. Effect of Cognitive Therapy With Antidepressant Medications vs Antidepressants Alone on the Rate of Recovery in Major Depressive Disorder: A Randomized Clinical Trial. JAMA 71:1157-1164, 2014.  25142196  
Sylvia L.G., Shelton R.C., Kemp D.E., Bernstein E.E., Friedman E.S., Brody B.D., McElroy S.L., Singh V., Tohen M., Bowden C.L., Ketter T.A., Deckersbach T., Thase M.E., Reilly-Harrington N.A., Nierenberg A.A., Rabideau D.J., Kinrys G., Kocsis J.H., Bobo W.V., Kamali M., McInnis M.G., Calabrese J.R. Medical burden in bipolar disorder: Findings from the CHOICE study. Bipolar Disorders Aug 16. doi: 10.1111/bdi.12243. [Epub ahead of print]  25130321 
Nierenberg, A.A., Sylvia, L.G., Leon, A.C., Reilly-Harrington, N.A., Shesler, L.W., McElroy, S.L., Friedman, E.S., Thase, M.E., Shelton, R.C., Bowden, C., Tohen, M., Singh, V., Deckersbach, T., Ketter, T., Kocsis, J.H., McInnis, M.G., Schoenfeld, D., Bobo, W.V., Calabrese, J.R., Bipolar CHOICE Study Group. Bipolar CHOICE: An illustration of a comparative effectiveness trial for a complex disorder. Clinical Trials 11:114-127, 2014.  24346608 
BDNF, interleukin-6, and salivary cortisol levels in depressed patients treated with desvenlafaxine. Ninan PT, Shelton RC, Bao W, Guico-Pabia CJ. Prog Neuropsychopharmacol Biol Psychiatry 48:86-91, 2014.   24096053 
Kálmán S., Garbett G., Vereczkei A., Shelton R.C., Korade Z., Mirnics K. Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts. Experimental Cell Research. 320:343-353, 2014.  24246224 
The effect of regulatory advisories on maternal antidepressant prescribing, 1995-2007: an interrupted time series study of 228,876 pregnancies. Bobo WV, Epstein RA Jr, Hayes RM, Shelton RC, Hartert TV, Mitchel E, Horner J, Wu P. Arch Womens Ment Health. 2013 Oct 3. [Epub ahead of print]
Papakostas G.I., Shelton R.C., Zajecka J., Bottiglieri T., Roffman J., Casseilo C., Stahl S.M., Fava M. Effect of adjunctive l-methylfolate 15 mg in depressed patients stratified by biomarker levels and genotype: results from a randomized clinical trial. J Clin Psychiatry 75:855-863, 2014.  24813065 
Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts. Kálmán S, Garbett KA, Vereczkei A, Shelton RC, Korade Z, Mirnics K. Exp Cell Res. 2014 Jan 15;320(2):343-53. doi: 10.1016/j.yexcr.2013.10.019. Epub 2013 Nov 16.
Cooper W.O., Callahan S.T., Shintani A., Fuchs D.C., Shelton R.C., Dudley J.A., Graves A.J., Ray W.A. Antidepressants and suicide attempts in children. Pediatrics 133:204-210, 2014.  24394688 
Clinical and Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE): A pragmatic trial of complex treatment for a complex disorder. Nierenberg AA, Sylvia LG, Leon AC, Reilly-Harrington NA, Shesler LW, McElroy SL, Friedman ES, Thase ME, Shelton RC, Bowden CL, Tohen M, Singh V, Deckersbach T, Ketter TA, Kocsis JH, McInnis MG, Schoenfeld D, Bobo WV, Calabrese JR; the Bipolar CHOICE Study Group.
Clin Trials. 2013 Dec 17.  
Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder. Sylvia LG, Friedman ES, Kocsis JH, Bernstein EE, Brody BD, Kinrys G, Kemp DE, Shelton RC, McElroy SL, Bobo WV, Kamali M, McInnis MG, Tohen M, Bowden CL, Ketter TA, Deckersbach T, Calabrese JR, Thase ME, Reilly-Harrington NA, Singh V, Rabideau DJ, Nierenberg AA. J Affect Disord. 2013 Nov;151(2):722-7. doi: 10.1016/j.jad.2013.07.031. Epub 2013 Aug 16.  23993440 
Webb CA, Derubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC. Convergence and divergence in the delivery of cognitive therapy in two randomized clinical trials. Behav Res Ther 51(8):493-8, 2013.  23792178 
Preston TC, Shelton RC. Treatment resistant depression: strategies for primary care. Curr Psychiatry Rep 15:370, 2013.  23712721 
Fournier JC, DeRubeis RJ, Hollon SD, Gallop R, Shelton RC, Amsterdam JD. Differential change in specific depressive symptoms during antidepressant medication or cognitive therapy. Behav Res Ther 51:392-8, 2013.  23644038  
Callahan ST, Fuchs DC, Shelton RC, Balmer LS, Dudley JA, Gideon PS, Deranieri MM, Stratton SM, Williams CL, Ray WA, Cooper WO. Identifying suicidal behavior among adolescents using administrative claims data. Pharmacoepidemiol Drug Saf 22:769-75, 2013.  23412882 
Papakostas GI, Vitolo OV, Ishak WW, Rapaport MH, Zajecka JM, Kinrys G, Mischoulon D, Lipkin SH, Hails KA, Abrams J, Ward SG, Meisner A, Schoenfeld DA, Shelton RC, Winokur A, Okasha MS, Bari MA, Fava M. A 12-week, randomized, double-blind, placebo-controlled, sequential parallel comparison trial of ziprasidone as monotherapy for major depressive disorder. J Clin Psychiatry 73:1541-7, 2012.   23290327 
Papakostas G.I., Shelton R.C., Zajecka J.M., Etemad B., Rickels K., Clain A., Baer L., Dalton E.D., Schoenfeld D., Pencina M., Meisner A., Bottiglieri T., Nelson E., Mischoulon D., Alpert J.E., Barbee J.G., Lydiard B., Zisook S., Fava M. l-methylfolate as adjunctive therapy for selective serotonin reuptake inhibitor-resistant major depressive disorder: results of two randomized, double-blind, parallel-sequential trials. American Journal of Psychiatry 169:1267-1274, 2012.  23212058  
Epstein RA, Bobo WV, Shelton RC, Arbogast PG, Morrow JA, Wang W, Chandrasekhar R, Cooper WO. Increasing use of atypical antipsychotics and anticonvulsants during pregnancy. Pharmacoepidemiol Drug Saf 22:794-801, 2013.  23124892 
Shelton R.C. Does concomitant use of NSAIDs reduce the effectiveness of antidepressants? (Editorial). Am J Psychiatry 169:1012-1015, 2012.  23032377 
Gibson SA, Korade Z, Shelton RC. Oxidative stress and glutathione response in tissue cultures from persons with major depression. Journal of Psychiatric Research 46:1326-1332, 2012.  22841833 
Treadway M.T., Buckholtz J.W., Cowan R.L., Woodward N.D., Li R., Ansari M.S., Baldwin R.M., Schwartzman A.N., Smith C.E., Bossaller N.A., Shelton R.C., Kessler R.M., Zald D.H. Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia. Journal of Abnormal Psychology 121:553-558, 2012.  22775583  
Hayes R.M., Wu P., Shelton R.C., Cooper W.O., Dupont W.D., Mitchel E., Hartert T.V. Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnancies. American Journal of Obstetrics and Gynecology 207:49.e1-9, 2012.  22727349 
Webb C., DeRubeis R., Dimidjian S., Hollon S., Amsterdam J., Shelton R. Predictors of patient cognitive therapy skills and symptom change in two randomized clinical trials: The role of therapist adherence and the therapeutic alliance. J Consult Clin Psychol 80:373-381, 2012.  22468907