Faculty Detail   
Name YIU-FAI CHEN
Professor of Medicine, Division of Cardiovascular Disease
 
Campus Address ZRB 1008 Zip 0007
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 Education

Undergraduate  National Taiwan University    1075  BS 
Graduate  National Taiwan University    1977  MS 
Graduate  University of Illinois (Champaign-Urbana)    1979  MS 
Graduate  University of Illinois (Champaign-Urbana)    1982  Ph.D. 
Fellowship  University of Alabama at Birmingham    1985  Post-Doc 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Cardiovascular Disease Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor

Society Memberships
Organization Name Position Held Org Link
The American Physiological Society
American Heart Association
The Endocrine Society
Society for Neuroscience
The American Society of Hypertension
American Association for the Advancement of Science
American Federation for Clinical Research
Society of Experimental Biology and Medicine
North American Vascular Biology Organization
 
   
 

Research/Clinical Interest
Title
1) Targeted Delivery of Endothelial Cells for the Repair of Cardiovascular Injury; 2) Mechanisms of Pressure-Overload induced Cardiac Remodeling; 3)Transforming Growth Factor-beta Mediates Effects of Hypoxia in Lung; 4) Mechanism of Hypertension
Description
Studies are aimed at understanding 1) pathogenesis of hypertension-induced cardiovascular and pulmonary diseases. A specific focus has been defining and characterizing the protective role of atrial natriuretic peptide in pressure overload-induced cardiac hypertrophy, remodeling and fibrosis, as well as in hypoxia-induced pulmonary hypertension and vascular remodeling; 2) delineate the mechanism(s) of the protective effects of i.v. administered adult ECs or iPS-ECs overexpressing IL8RA and IL8RB in rats with experimental vascular or cardiac injury. We hypothesize that adult ECs or iPS-ECs that overexpress IL8 receptors will mimic the behavior of neutrophils that target and adhere to injured tissues (e.g. to endoluminal surface and adventitia of injured arteries) and in doing so will compete with and inhibit neutrophil infiltration and attenuate subsequent inflammatory responses and structural and functional damage to tissues. .

Selected Publications 
Zhao X, Zhang W, Xing D, Li P, Gong K, Hage F, Oparil S, Chen YF. Endothelial cells overexpressing IL-8 receptor reduce cardiac remodeling and dysfunction following myocardial infarction. Am J Physiol 305:H590-H598, 2013.  23771691 
Zhao X, Zhang W, Xing D, Li P, Gong K, Hage F, Oparil S, Chen YF. Endothelial cells overexpressing IL-8 receptor reduce cardiac remodeling and dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol 305:H590-598, 2013.  23771691 
Wan M, Li C, Zhen G, Jiao K, He W, Jia X, Wang W, Shi C, Xing Q, Chen YF, Jan De Beur S, Yu B, Cao X. Injury-activated transforming growth factor β controls mobilization of mesenchymal stem cells for tissue remodeling. Stem Cells 30:2498-511, 2012.  22911900 
Hilgers R, Xing D, Gong K, Chen YF, Chatham J, Oparil S. Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction. Am J Physiol 303:H513-H522, 2012  22777418 
Hilgers R, Xing D, Gong K, Chen YF, Chatham J, Oparil S. Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction. Am J Physiol 303:H513-H522, 2012.   22777418 
Xing D, Li P Gong K, Yu H, Yang Z, Hage F, Oparil S, Chen YF. Endothelial cells overexpressing interleukin-8 (IL8) receptors reduce inflammatory and neointimal responses to arterial injury. Circulation 125:1533-1541, 2012.  22361324 
Olave N, Nicola T, Zhang W, Bulger A, James ML, Oparil S, Chen YF, Ambalavanan N. Transforming growth factor-beta regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure. Am J Physiol 302:L857-L865, 2012.  22287612 
Gong K, Xing D, Li P, Aksut B, Ambalavanan N, Yang Q, Nozell SE, Oparil S, Chen YF. Hypoxia induces downregulation of PPAR in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor- signaling. Am J Physiol 301:L899-907, 2011.   21926264 
Xing D, Gong K, Feng W, Nozell SE, Chen YF, Chatham JC, Oparil S. O-GlcNAc modification of NFB p65 inhibits TNF--induced inflammatory mediator expression in rat aortic smooth muscle cells. PLoS One 6(8):e24021, 2011.  21904602 
Gong K, Chen YF, Li P, Lucas JA, Hage FG, Yang Q, Nozell SE, Oparil S, Xing D. Transforming growth factor- inhibits myocardial PPAR expression in pressure overload-induced cardiac fibrosis and remodeling in mice. J Hypertens 29:1810-1819, 2011  21836474 
Xing D, Oparil S, Yu H, Gong K, Feng W, Black J, Chen YF, Nozell S. Estrogen Modulates NFκB Signaling by Enhancing IκBα Levels and Blocking 1 p65 Binding at the 2 Promoters of Inflammatory Genes via Estrogen Receptor-β. PLoS One 7(6):e36890, 2012.   2272862 
Fu J, Chen YF, Zhao X, Creighton J, Guo YY, Hage FG, Oparil S, Xing D. Targeted Delivery of Pulmonary Arterial Endothelial Cells Overexpressing Interleukin-8 Receptors Attenuates Monocrotaline-Induced Pulmonary Vascular Remodeling. ATVB, In Press, 2014.   
Ma HR, Wang J, Chen YF, Chen Hua, Wang WS, Aisa HA. Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway. International J Mol Med 33:1627-1634, 2014.   
Szalai A, McCrory MA, Xing D, Hage FG, Miller A, Oparil S, Chen YF, Mazzone M, Early R, Henry SP, Zanardi T, Graham M, Crooke RM. Inhibiting C-reactive protein for the treatment of cardiovascular disease. Mediators of Inflammation, Volume 2014, Article ID 353614.   
 

Keywords
Systemic hypertenion, Pulmonary hypertension, Vascular injury, Cardiac hypertrophy, fibrosis and remodeling, Pulmonary vascular hypertrophy and remodeling, Targeted cell therapy, iPS cells, Atrial natriuretic peptide, Endothelin, Estrogen.