UASOM Faculty Profiles

Faculty Detail


Name	AMJAD JAVED
Campus Address	SDB 714 Zip 0007
Phone	(205) 996-5124
E-mail	javeda@uab.edu
Other websites

Faculty Appointment(s)

Appointment Type Department Division Rank

Primary Oral & Maxillofacial Surgery Oral & Maxillofacial Surgery Professor

Secondary Biomedical Engineering Biomedical Engineering Assistant Professor

Secondary Cell, Developmntl, & Integrative Biology Cell, Developmntl, & Integrative Biology Professor

Secondary Otolaryngology Chair Office Otolaryngology Chair Office Professor

Secondary Pathology Chair Office Pathology Chair Office Assistant Professor

Center Biomatrix Eng Regen Med (BERM) Ctr Biomatrix Eng Regen Med (BERM) Ctr Professor

Center Comp Arthritis, MSK, Bone & Autoimmunity Ctr Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor

Center Comprehensive Cancer Center Comprehensive Cancer Center Professor

Center Comprehensive Diabetes Center Comprehensive Diabetes Center Professor

Center Ctr for Clinical & Translational Sci Ctr for Clinical & Translational Sci Professor

Center Ctr for Exercise Medicine (Org Ret) Ctr for Exercise Medicine (Org Ret) Professor

Center Ctr Nanoscale Mat & Biointegration Ctr Nanoscale Mat & Biointegration Professor

Center GL Ctr for Craniofacial, Oral, & Dental Disorders GL Ctr for Craniofacial, Oral, & Dental Disorders Professor

Center Integrative Center for Aging Research Integrative Center for Aging Research Professor

Center Nutrition Sciences Research Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations

Cancer Biology

Cell, Molecular, & Developmental Biology

Cellular and Molecular Biology Program

Genetics, Genomics and Bioinformatics

Medical Scientist Training Program

Biographical Sketch

coming soon

Society Memberships

Organization Name Position Held Org Link

American Dental Education Association Member www.adea.org

American Society for Bone and Mineral Research Member www.asbmr.org

International Association for Dental Research Member www.iadr.com

Research/Clinical Interest

Title
Genetic and Molecular Signaling for Cellular Differentiation and Skeletogenesis
Description
The central focus of our laboratory is to understand the molecular mechanisms that govern the formation and remodeling of skeletal tissues such as Cartilage, Bone, Teeth and Tendon. Cellular differentiation involves the stepwise establishment of specific genetic programs in proliferating cell lineages. We are exploring the signalling role of runt related transcription factor (Runx), in the coordinated regulation of various cell types (Chondrocyte, Osteoblast, Odontoblast) during skeletogenesis. Runx factors are heterodimers formed by α and β subunit and are essential for embryonic development. In mammals three genes encode α subunits (Runx1, 2 and 3) that recognize the same DNA sequences in target gene promoters yet exhibit distinct and non-redundant biological functions. Runx1 is required for definitive hematopoiesis and is frequently mutated in human leukemia. Runx2 is required for osteogenesis and in human mutations of the Runx2 gene are associated with cleidocranial dysplasia, an autosomal dominant skeletal disorder characterized by clavicular and pelvic anomalies, multiple supernumerary teeth, and a sever delay in closure of the fontanels. Runx3 controls neurogenesis, development and proliferation of the gastric epithelium and is frequently silenced in human gastric cancer. Runx2 knock-in and knock-out mouse models are lethal and show a complete absence of both intramembranous and endochondral ossification. Our lab utilizes conditional null model with biochemical, cellular, genetic and molecular approaches to identify molecular pathways during post-natal bone formation, bone remodeling, fracture healing, osteoporosis, osteoarthritis metabolic diseases (diabetes, obesity) and aging.

Selected Publications

Runx2 regulates gene network associated with insulin signaling and energy homeostasis. Cells Tissues Organs. 2011 May;194(2-4):232-237 21597275

Chondrocyte specific regulatory activity of Runx2 is essential for survival and skeletal development. Cells Tissues Organs. 2011 May;194(2-4):161-165 21597273

Genetic and transcriptional control of bone formation. Oral Maxillofac Surg Clin North Am. 2010 Aug;22(3):283-293. 20713262

A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet. 2009 Feb 1;18(3):556-68 19028669

Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx-2 by AKT signaling. J. Biol. Chem. 2008. May 30;283(22):15319-15327 18378684

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J. Biol. Chem. 2008 March 28 283(13): 8412-8422 18204048

Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.
Nature. 2007 Jan 25;445(7126):442-6.
17251981

Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation.
J Cell Biochem. 2007 Feb 1;100(2):434-49.
16927309

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1454-9. 15665096

Analysis of in vivo gene expression using epitope-tagged proteins.
Methods Mol Biol. 2004;285:37-40. 15269395

Cbfbeta interacts with Runx2 and has a critical role in bone development.
Nat Genet. 2002 Dec;32(4):639-44. 12434156

CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression.
J Biol Chem. 2002 Jan 11;277(2):1316-23. 11668178

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development.
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8650-5. 11438701

runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins.
Mol Cell Biol. 2001 Apr;21(8):2891-905.
11283267

Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization.
Mol Cell Biol. 1999 Nov;19(11):7491-500.
10523637

Keywords

Osteoblast, Bone Development, Gene Regulation, Osteoporosis