Faculty Detail    Name MAJD ZAYZAFOON   Campus Address VH 201- Zip 0019 Phone  (205) 934-5574 E-mail  mzayzafoon@uab.edu Other websites

 Education

Faculty Appointment(s) Appointment Type Department Division Rank Primary  International Medical Education  International Medical Education Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Secondary  Dept of Medical Education  Dept of Medical Education Associate Professor Center  Biomatrix Eng Regen Med (BERM) Ctr  Biomatrix Eng Regen Med (BERM) Ctr Professor Center  Cell Adhesion & Matrix Research Center  Cell Adhesion & Matrix Research Center Professor Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor Center  Nutrition Sciences Research  Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations Cancer Biology  Cell, Molecular, & Developmental Biology  Cell, Molecular, & Developmental Biology  Medical Scientist Training Program  Molecular and Cellular Pathology Program  Pathobiology and Molecular Medicine

Society Memberships Organization Name Position Held Org Link American Association for Cancer Research    http://www.aacr.org/  American Association for the Advancement of Science     http://www.aaas.org/  American Society for Biochemistry and Molecular Biology    http://www.asbmb.org/  American Society for Bone and Mineral Research    http://www.asbmr.org/  American Society for Gravitational and Space Biology    http://www.asgsb.org/  British Association for Cancer Research    http://www.bacr.org.uk/  European Association for Cancer Research    http://www.eacr.org/  International Bone and Mineral Society    http://www.ibmsonline.org/  New York academy of sciences    http://www.nyas.org/  The Metastasis Research Society    http://www.metastasis-research.org/

Selected Publications  RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization.   24478054  NFAT Signaling in Osteoblasts Regulates the Hematopoietic Niche in the Bone Microenvironment.   24023563  Inhibition of beta 2-Microglobulin/Hemochromatosis Enhances Radiation Sensitivity by Induction of Iron Overload in Prostate Cancer Cells.   23874600  Childhood obesity as a risk factor for bone fracture: A Mechanistic Study  23512354  Alpha-CaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma.  23364534  Central Depletion of Brain-Derived Neurotrophic Factor in Mice Results in High Bone Mass and Metabolic Phenotype.   23011922  Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation.   22583901  LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling.  22110740  Is there a role for fatty acid synthase in the diagnosis of prostatic adenocarcinoma?  21757596  Beta 2-Microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells  21427356  Human prostate cancer harbors the stem cell properties of bone marrow mesenchymal stem cells  21355075   Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand  21187391  Snail-mediated regulation of reactive oxygen species in ARCaP human prostate cancer cells  21093414  Alterations in the immune-skeletal interface drive bone destruction in HIV-1 transgenic rats  20643942  Effect of HIP/Ribosomal Protein L29 Deficiency on Mineral Properties of Murine Bones and Teeth  20362701  Ex Vivo Transfer of the Hoxc-8-interacting Domain of Smad1 by a Tropism-Modified Adenoviral Vector Results in Efficient Bone Formation in a Rabbit Model of Spinal Fusion  20084034  T lymphocytes amplify the anabolic activity of parathyroid hormone through WNT10b signaling  19723499  NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation  19463978  Mecp2 Deficiency Decreases Bone Formation and Reduces Bone Volume in a Rodent Model of Rett Syndrome  19414073  Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment  18850577  Immunohistochemistry in the Evaluation of Neovascularization in Tumor Xenografts: Antibody Selection and Antigen Retrieval Method Optimization  18846440  BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells by inducing apoptosis  18829499  Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells  18645583  Conditional dysruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption  17884821  Alpha-CaMKII Controls the Growth of Human Osteosarcoma by Regulating Cell Cycle Progression  17632540  Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation.  17392048  Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro.   17373717   Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells.  17326044  {beta}2-Microglobulin Promotes the Growth of Human Renal Cell Carcinoma through the Activation of the Protein Kinase A, Cyclic AMP-Responsive Element-Binding Protein, and Vascular Endothelial Growth Factor Axis  17189401   beta2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis  16982753  NFATc1: a novel anabolic therapeutic target for osteoporosis  16831953  Inhibition of NFAT increases osteoblast differentiation by increasing Fra-2 expression  16340132  Microgravity: the immune response and bone  16313354  Calcium/calmodulin signaling controls osteoblast growth and differentiation  16229015  RhoA and Cytoskeletal Disruption Mediate Reduced Osteoblastogenesis and Enhanced Adipogenesis of Human Mesenchymal Stem Cells in Modeled Microgravity.  16160744  Modeled microgravity disrupts collagen I/integrin signaling during osteoblastic differentiation of human mesenchymal stem cells  15660414  RANKL regulates Fas expression and Fas-mediated apoptosis in osteoclasts  15619676  Calmodulin and calmodulin-dependent kinase IIalpha regulate osteoblast differentiation by controlling c-fos expression  15590632  Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis  14749352  Notch signaling and ERK activation are important for the osteomimetic properties of prostate cancer bone metastatic cell lines  14602722  P38 and activating transcription factor-2 involvement in osteoblast osmotic response to elevated extracellular glucose  12149242  Extracellular glucose influences osteoblast differentiation and c-Jun expression  10967557