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Faculty Detail    
Name TALENE ALENE YACOUBIAN
 
Campus Address CIRC 560D Zip 0021
Phone  (205) 996-7543
E-mail  tyacoub@uab.edu
Other websites http://labs.uab.edu/tyacoub/
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Education
Undergraduate  Harvard College    1993  A.B. in Biochemical Sciences 
Medical School  Duke University School of Medicine    2001  MD 
Graduate  Duke University    2001  PhD in Neurobiology 
Residency  Partners Neurology Residency Program at Massachusetts General and Brigham and Women’s Hospitals    2005  Neurology Residency 
Fellowship  Massachusetts General and Brigham and Women’s Hospitals     2006  Fellowship in Movement Disorders 
Fellowship  University of Alabama at Birmingham    2007  Fellowship in Movement Disorders 


Faculty Appointment(s)
Appointment Type Department Division Rank
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor
Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Professor
Center  Neurology   Alzheimer's Disease Center Professor
Center  Neurology   Multiple Sclerosis Center Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Primary  Neurology   Neurology Chair Office Professor
Secondary  Neurobiology  Neurobiology Assistant Professor

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 
Medical Scientist Training Program 
Neuroscience 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Talene Yacoubian, MD, PhD, joined the Department of Neurology in July of 2006, and is currently an Assistant Professor. Dr. Yacoubian received her undergraduate degree from Harvard University, and her MD/PhD from Duke University in 2001. She completed a one year internship at Brigham & Women's Hospital, Boston and a 3 year Residency in Neurology at Massachusetts General Hospital/Brigham & Women's Hospital. She finished a two year Fellowship in Movement Disorders in July of 2007. She is an Assistant Professor in the Center for Neurodegeneration and Experimental Therapeutics and the Parkinson's Association of Alabama Scholar. She currently divides her time between patient care and laboratory research focused on Parkinsonís disease.

Society Memberships
Organization Name Position Held Org Link
Alpha Omega Alpha Medical Society  Member   
American Academy of Neurology  Member   
Movement Disorders Society  Member   
Society for Neuroscience  Member   



Research/Clinical Interest
Title
Role of 14-3-3 proteins in Parkinsonís disease
Description
The Yacoubian Lab is focused on understanding the pathophysiology of Parkinson's disease with the long-term goal of developing neuroprotective therapies. The main focus of the lab is the family of 14-3-3 proteins and their role in Parkinson's disease. We have demonstrated disruption of 14-3-3 expression and function in Parkinson's disease models and shown that these proteins can reduce toxicity in several PD models. We are currently investigating how 14-3-3 proteins can regulate alpha-synuclein and LRRK2, two key genes implicated in PD. We employ a variety of cellular, molecular, and in vivo techniques.

Selected Publications 
Publication PUBMEDID
No records

Keywords
Parkinsons disease; Neurobiology; Molecular Genetics & Disease