Pathobiology and Molecular Medicine  Back to Main

Faculty Detail    
Campus Address VH 202 Zip 0019
Phone  (205) 934-5679
Other websites

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary    Associate Professor Adjunct

Graduate Biomedical Sciences Affiliations
Integrative Biomedical Sciences 
Pathobiology and Molecular Medicine 

Society Memberships
Organization Name Position Held Org Link
Society for Free Radical Biology and Medicine  Member 

Research/Clinical Interest
Redox cell signaling and environmental exposures; natural products and chemoprevention

Selected Publications 
Publication PUBMEDID
Parkes T.L, Elia A.J., Dickinson D., Hilliker A.J., Phillips J.P. and G.L. Boulianne
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
Nature Genetics 19(2):171-174, 1998.  
King A.L., Swain T.M., Dickinson D.A., Lesort M.J. and S.M. Bailey
Chronic ethanol consumption enhances sensitivity to Ca2+-mediated opening of the mitochondrial permeability transition pore and increases cyclophilin D in liver.
American Journal of Physiology - Gastrointestinal and Liver Physiology 299(4):G954-G966. 2010. 
Iles K.E., Song W., Miller D.W., Dickinson D.A. and S. Matalon
Reactive species and pulmonary edema
Expert Review of Respiratory Medicine 3(5):487-496. 2009.
Andringa K.K, King A.L., Eccleston H.B., Mantena S.K., Landar A., Jhala N.C., Dickinson D.A., Squadrito G.L., and S.M. Bailey
Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: Novel molecular targets of disease and hepatoprotection.
American Journal of Physiology 298(5):G732-G745. 2010.
Koenitzer J.R., Isbell T.S., Patel H.D., Benavides G.A., Dickinson D.A., Patel R.P., Darley-Usmar V.M., Lancaster J.R., Doeller J.E. and D.W. Kraus
Hydrogen sulfide mediates vasoactivity in an O2-dependent manner
American Journal of Physiology 290(5):H1953-H1960. 2007.
Zhang H., Liu H., Dickinson D.A., Liu R.-M., Postlethwait E.M., Laperche Y. and H.J. Forman
gamma-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells
Free Radical Biology & Medicine 40(8):1281-1292. 2006.  
Landar A., Zmijewski J.W., Dickinson D.A., Le Goffe C., Johnson M., Milne G., Zanoni G., Vidari G., Morrow J.D. and V.M. Darley-Usmar
Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and the formation of reactive oxygen species
American Journal of Physiology 290(5):H1777-H1787. 2006. 
Zmijewski J.W., Landar A., Watanabe N., Dickinson D.A., Noguchi N., and V.M. Darley-Usmar
Cell signaling by oxidized lipids and the role of reactive oxygen species in the endothelium
Biochemical Society Transactions 33(6):1385-1389. 2005.  
Martin M.E., Muňoz F.M., Dickinson D.A., Forman H.J., del Rio R.M., Salinas M. and J.L. Fando
Protective effect of L-trans-pyrrolindine-2,4-dicarboxilic acid preload against ischemia-induced cell death in differentiated PC12 cells
Journal of Neuroscience Research 82(1):93-102. 2005. 
Iles K.E.*, Dickinson D.A.*, Wigley A.F, Welty N.E., Blank V. and H. J. Forman
HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells
Free Radical Biology & Medicine 39(3):355-364. 2005. 
Ridnour L.A., Sim J.E., Choi J., Dickinson D.A., Forman H.J., Ahmad I.M., Coleman M.C., Hunt C.R., Goswami P.C. and D.R. Spitz
Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process
Free Radical Biology & Medicine 38(10):1361-1371. 2005.  
Zhang H., Dickinson D.A., Liu R.-M. and H.J. Forman
4-Hydroxynonenal increases gamma-glutamyl transpeptidase gene expression through mitogen activated protein kinase pathways
Free Radical Biology & Medicine 38(4):463-471. 2005. 
Dickinson D.A., Levonen A.-L., Moellering D.R., Arnold E.K., Zhang H., Darley-Usmar V.M. and H.J. Forman
Human glutamate cysteine ligase gene regulation through the electrophile response element
Free Radical Biology & Medicine 37(8):1152-1159. 2004. 
Krzywanski D.M., Dickinson D.A., Iles K.E., Wigley A.F., Franklin C.C., Liu R.-M., Kavanagh T.J. and H.J. Forman
Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress
Archives in Biochemistry and Biophysics 423(1):116-125. 2004.  
Ceaser E.K., Moellering D.R., Shiva S., Ramachandran A., Landar A., Venkartraman A., Crawford J., Patel R.P., Dickinson D.A., Ulasova E., Ji S. and V.M. Darley-Usmar
Mechanisms of signal transduction mediated by oxidized lipids: the role of the electrophilic responsive proteome
Biochemical Society Transactions 32(1):151-155. 2004.  
Levonen A.-L., Landar A., Ramachandran A., Ceaser E.K., Dickinson D.A., Zanoni G., Morrow J.D. and V.M. Darley-Usmar
Cellular mechanisms of redox cell signaling: the role of cysteine modification in controlling antioxidant defenses in response to electrophilic lipid oxidation products
Biochemical Journal 378(2):373-382. 2004. 
Liu R.-M. and D.A. Dickinson
Decreased synthetic capacity underlies the age-associated decline in glutathione content in Fisher 344 rats
Antioxidants & Redox Signaling 5(5):529-536. 2003.  
Forman H.J., Dickinson D.A. and K.E. Iles
HNE – Signaling pathways leading to its elimination
Molecular Aspects of Medicine 24(4-5):189-194. 2003.  
Dickinson D.A., Moellering D.R., Iles K.E., Patel R.P., Levonen A.-L., Wigley A., Darley-Usmar V.M. and H.J. Forman
Cytoprotection against oxidative stress and the regulation of glutathione synthesis
Biological Chemistry 384(4):527-537. 2003.  
Watanabe N., Iwamoto T., Bowen K.D., Dickinson D.A., Torres M. and H.J. Forman
Bio-effectiveness of Tat-catalase conjugate: A potential tool for the identification of H2O2-dependent cellular signal transduction pathways
Biochemical and Biophysical Research Communications 303(1):287-293. 2003.  
Dickinson D.A., Iles K.E., Zhang H., Blank, V. and H.J. Forman
Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression
FASEB Journal Express (January 2, 2003) 10.1096/fj.02-0566fje. (Full text – online)
FASEB Journal 17(3):473-475. 2003. (Print version summary)  
Dickinson D.A. and H.J. Forman
Glutathione in defense and signaling: lessons from a small thiol.
Annals of the New York Academy of Sciences 973: 488-504. 2002.  
Dickinson D.A., Iles K.E., Watanabe N., Iwamoto T., Zhang H., Krzywanski D.M. and H.J. Forman
4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells
Free Radical Biology & Medicine 33(7):974-987. 2002.  
Watanabe N., Iwamoto T., Dickinson D.A., Iles K.E. and H.J. Forman
Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinase
Archives of Biochemistry and Biophysics 405(2):231-240. 2002.  
Dickinson D.A. and H.J. Forman
Cellular glutathione and thiols metabolism
Biochemical Pharmacology 64(5-6):1019-1026. 2002.
Iles K.E., Dickinson D.A., Watanabe N., Iwamoto T. and H.J. Forman
AP-1 activation through endogenous H2O2 generation by alveolar macrophages
Free Radical Biology & Medicine 32(12):1304-1311. 2002.  
Levonen A.-L., Dickinson D.A., Moellering D.R., Mulcahy R.T., Forman H.J. and V.M. Darley-Usmar
Biphasic effects of 15-deoxy-(12,14)-prostaglandin J2 on glutathione induction and apoptosis in human endothelial cells
Arteriosclerosis, Thrombosis and Vascular Biology 21(11):1846-1851, 2001.  

glutathione; redox; Nrf2; antioxidant; microRNA; nutraceutical