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Faculty Detail    
Name GANGJIAN QIN
Professor and Vice Chair for Research
Department of Biomedical Engineering
Director, Molecular Cardiology Program
 
Campus Address VH G094 Zip 0019
Phone  (20-5) -690
E-mail  gqin@uab.edu
Other websites SOE
UAB news 1
UAB news 2
     

Education
Graduate  Tongji Medical University, China    1989  MD/MS 
Fellowship  Int’l Centre for Genetic Engineering and Biotechnology (ICGEB), Italy    1995-1998  Post-doc 
Fellowship  University of Illinois at Chicago (UIC), IL    1998-2001  Post-doc 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Dept of Biomedical Engineering  Dept of Biomedical Engineering Professor

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 
Medical Scientist Training Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Gangjian Qin is Professor of Medicine and Engineering, Director of the Molecular Cardiology Program, Vice Chair for Research of Department of Biomedical Engineering at the University of Alabama at Birmingham. Before he joined UAB in July 2016, Dr. Qin served on the faculty of Northwestern University Feinberg School of Medicine for 9 years as assistant professor to tenured associate professor. Dr. Qin’s education background include an MD from Tongji Medical College in China, postdoc and research faculty training from International Centre for Genetic Engineering and Biotechnology Italy, University of Illinois at Chicago, and St. Elizabeth Medical Center of Boston Tufts University.

Society Memberships
Organization Name Position Held Org Link
AHA Basic Cardiovascular Science Council  Membership and Communications Committee   
American Heart Association  FAHA   



Research/Clinical Interest
Title
Stem Cell Biology, Metabolism, and Cardiovascular Regeneration
Description
Dr. Qin’s research program is dedicated to defining the molecular mechanisms that underlie cardiovascular biology and contribute to the recovery from cardiovascular disease, and to translating the results from these basic science investigations to clinical applications. His laboratory revealed the role of E2F oncogenes in angiogenesis and blood pressure regulations. His serial work on bone marrow and cardiac stem cells contributed to the advancement of the field of ischemic tissue repair. Ongoing research in Qin lab focuses on the pathophysiology of cardiovascular microvesicles and exosomes, epigenetic mechanisms of cardiac differentiation of embryonic and induced-pluripotent stem cells, peptide-based nanoparticles for enhancing the therapeutic benefit of human progenitor cells in pre-clinical models, and novel signaling pathways in gluconeogenesis and adipose thermogenesis linked to obesity and diabetes. Dr. Qin has published over 100 original research articles in mainstream journals, including Circulation, Circ Res, J Clin Invest, J Exp Med, PNAS, and Nat Comm. His research has been supported by the National Institute of Health (NIH), American Heart Association (AHA), and American Diabetes Association (ADA). In addition, Dr. Qin serves on the editorial board of multiple journals in stem cell biology and cardiovascular sciences including Circ Res, and on the review committees of national and international funding organizations including NIH, VA, and AHA. Dr. Qin also serves on the Council on Basic Cardiovascular Science (BCVS) and Council on Cardiovascular Radiology and Intervention (CVRI) of AHA. Over the last 15 years, Dr. Qin has trained or is training 45 research trainees at multiple academic levels, and several fellows from his lab have attained independent faculty positions in the US and abroad.

Selected Publications 
Publication PUBMEDID
Han D, Yang J, Zhang E, Liu Y, Boriboun C, Qiao A, Yu Y, Sun J, Xu S, Yang L, Yan W, Luo B, Lu D, Zhang C, Jie C, Mobley J, Zhang J, Qin G. Analysis of mesenchymal stem cell proteomes in situ in the ischemic heart. Theranostics 2020;10:11324-11338.  33042285 
Han S, Xu S, Zhou J, Qiao A, Boriboun C, Ma W, Li H, Biyashev D, Yang L, Zhang E, Liu Q, Jiang S, Zhao TC, Krishnamurthy P, Zhang C, Richard S, Qiu H, Zhang J, Qin G. Sam68 impedes the recovery of arterial injury by augmenting inflammatory response. J Mol Cell Cardiol 2019 Oct 19 [Epub ahead of print]  31639388 
Cheng M, Yang J, Zhao X, Zhang E, Zeng Q, Yu Y, Yang L, Wu B, Yi G, Mao X, Huang K, Dong N, Xie M, Limdi NA, Prabhu SD, Zhang J, and Qin G Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells. Nat Comm 2019;10(1):959 doi: 10.1038/s41467-019-08895-7.  30814518 
Xu S, Tao J, Yang L, Zhang E, Boriboun C, Zhou J, Sun T, Cheng M, Huang K, Dong N-G, Liu Q, Zhao TC, Qiu H, Harris RA, Chandel NS, Losordo DW, Qin G. E2F1 suppresses oxidative metabolism and endothelial differentiation of bone marrow progenitor cells. Circ Res 2018; 122(5):701-11  29358228 
Zhu W, Zhang E, Zhao M, Chong Z, Fan C, Tang Y, Hunter JD, Borovjagin AV, Walcott GP, Chen JY, Qin G, and Zhang J. Regenerative Potential of Neonatal Porcine Hearts. Circulation 2018 Dec 11;138(24):2809-2816. PMID: 30030418. PMCID: PMC6301098  30030418 
Wang H, Zhao YT, Zhang S, Dubielecka PM, Du J, Yano N, Chin YE, Zhuang S, Qin G, Zhao TC. Irisin Plays a Pivotal Role to Protect the Heart Against Ischemia and Reperfusion Injury†. J Cell Physiol 2017; 232(12):3775-3785  28181692 
Arnone B, Chen JY, Qin G. Characterization and analysis of long noncoding rna (lncRNA) in In Vitro- and Ex Vivoderived cardiac progenitor cells. PLoS ONE 2017;12(6): e0180096  28640894 
Swartz KL, Wood SN, Murthy T, Ramirez O, Qin G, Pillai MM, Rao S, Minella AC. E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol. 2016 Dec 19;37(1). pii: e00274-16.   27795297 
Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom JA, Kume T. Foxc1 regulates early cardiomyogenesis and functional properties of embryonic stem cell derived cardiomyocytes. Stem Cells 2016;34:1487-500.  26824887 
Cheng M, Huang K, Zhou J, Tang Y-L, Zhao TC, Miller RJ, Kishore R, Losordo DW, and Qin G. A Critical Role of Src Family Kinase in SDF-1/CXCR4-Mediated Bone-Marrow Progenitor Cell Recruitment to the Ischemic Heart. J Mol Cell Cardiol 2015; 81:49-53  25655934 
Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao T, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol 2015; 225:181-9  25934704 
Tongers J, Webber MJ, Vaughan EE, Sleep E, Renault M-A, Roncalli JG, Klyachko E, Thorne T, Yu Y, Marquardt K-T, Kamide CE, Ito A, Misener S, Millay M, Liu T, Jujo K, Qin G, Losordo DW, Stupp SI, Kishore R. Enhanced potency of cell-based therapy for ischemic tissue repair using an injectable bioactive epitope presenting nanofiber support matrix, J Mol Cell Cardiol 2014;74:231-9   25009075 
Wu M., Zhou J., Cheng M., Boriboun C., Biyashev D., Wang H., Mackie A., Thorne T., Cho J., Wu Y., Chen Z., Yan H., Kishore R., Taylor R.N., Losordo D.W., Qin G. E2F1 Suppresses Cardiac Neovascularization by Downregulating VEGF and PlGF Expression. Cardiovasc Res 2014;104:412-22.   25341896 
Zhou J, Cheng M, Wu M, Boriboun C, Jujo K, Xu S, Zhou TC, Tang YL, Kishore R, and Qin G. Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis J Mol Cell Cardiol 2013;60:68-71  23603666 
Jujo K, Ii M, Sekiguchi H, Klyachko E, Misener S, Tanaka T, Tongers J, Roncalli J, Renault M-A, Thorne T, Ito A, Clarke T, Kamide C, Tsurumi Y, Hagiwara N, Qin G, Asahi M, MD, Losordo DW. CXC-Chemokine Receptor 4 Antagonist AMD3100 Promotes Cardiac Functional Recovery After Ischemia/Reperfusion Injury via Endothelial Nitric Oxide Synthase–Dependent Mechanism. Circulation 2012;127:63-73 PMID: 23204107 (Editorial commended)  23204107 
Sahoo S, Klyachko E, Thorne T, Misener S, Shinnick K, Millay M, Ito A, Liu T, Kamide C, Agarwal H, Perlman H, Qin G, Kishore R, Losordo DW. Exosomes from Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity. Cir Res 2011. 109:724-8  21835908 
Cheng M, Zhou J, Wu M, Boriboun C, Thorne T, Liu T, Xiang Z, Zeng Q, Tanaka T, Tang YL, Kishore R, Tomasson MH, Miller RJ, Losordo DW, Qin G. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 2010;107:1083-93. (Cover featured; Editors pick)   20847314 
Zhou J., Zhu Y., Cheng M., Dinesh D., Thorne T., Poh K.K., Liu D., Botros C., Tang Y.L., Reisdorph N., Kishore R., Losordo D.W., and Qin G., Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation, 2009. 120: 1213-21. (Editors pick)  19752322 
Tang YL, Zhu W, Cheng M, Chen L, Zhang J, Sun Tao, Kishore R, Phillips MI, Losordo DW, Qin G. Hypoxic Preconditioning Enhances the Benefit of Cardiac Progenitor-Cell Therapy for Treatment of Myocardial Infarction by Inducing CXCR4 Expression. Circ Res 2009;104:1209-16. (Editorial commended; Cover featured)   19407239 
Qin G.¶, Kishore R., Dolan C.M., Silver M., Wecker A., Luedemann C.N., Thorne T., Hanley A., Curry C., Heyd L., Dinesh D., Kearney M., Martelli F., Murayama T., Goukassian D.A., Zhu Y., and Losordo D.W.¶, Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A, 2006. 103:11015-20.  16835303 
Qin G, Ii M, Wecker A, Bord E, Ma H, Gavin M, Goukassian DA, Yoon YS, Papayannopoulou T, Asahara T, Kearney M, Thorne T, Curry C, Eaton L, Heyd L, Dinesh D, Kishore R, Zhu Y, and Losordo DW. Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med 2006;203:153-63.  16401693 

Keywords
Stem Cell, Regeneration, Ischemic Heart Disease, Heart Failure, Angiogenesis, Inflammation, Metabolism, Obesity, Diabetes, E2F, CXCR4, Sam68