Cell, Molecular, & Developmental Biology  http://www.gbs.uab.edu  http://www.uab.edu/graduate  Back to Main

Faculty Detail    
Name STIJN DE LANGHE
Tenured Associate professor
Endowed Professor in Lung Development and Regeneration
Director Program in Lung Development and Regeneration.		  
Campus Address SHEL 302 Zip 0006
Phone  (20-5) -890
E-mail  delanghe@uab.edu
Other websites
     

Education
Undergraduate  Ghent university    1998  Biotechnology 
Graduate  Ghent University/USC keck School of Medicine    2005  Ph.D. 
Fellowship  University of Southern California    2007  Post Doc. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Pulmonary/Allergy/Critical Care Associate Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Cell, Molecular, & Developmental Biology 

Biographical Sketch 
Dr. De Langhe received his BS, MS and PhD degree from Ghent University. He completed PhD and postdoctoral training at USC and was appointed as an Assistant Professor at National Jewish Health and UC Denver School of Medicine in 2007. Dr. De Langhe joined the faculty of Department of Medicine at UAB in January 2017. He is currently Tenured Associate professor of Medicine, Endowed Professor in Lung Development and Regeneration. He is the Director of the Program in Lung Development and Regeneration. Dr. De Langhe has served on several grant review panels of the National Institutes of Health (NIH), Pulmonary fibrosis foundation and Cystic fibrosis foundation.



Research/Clinical Interest
Title
Lung stem cells and their niches.
Description
Our laboratory focuses on lung stem/progenitor cell biology, lung development and regeneration after injury. We seek to clarify the mechanistic basis of bidirectional signaling between lung stem cells and their niche which informs lung stem cell fate decisions, including choices between quiescence or proliferation, self-renewal or differentiation, migration or retention and cell death or survival. Our inquiries into the molecular mechanisms underlying adult lung epithelial regeneration will serve as a framework within which we seek to understand how aberrant activation of normal developmental processes results in human lung diseases. Our work relies heavily on transgenic mice models, and histological analysis, primary cell cultures, etc. We are primarily interested in transferring our knowledge on lung development to repair and disease processes in the adult lung. All our data indicate that adult lung cells hijack the pathways important for lung development to respond to injury.

Selected Publications 
Publication PUBMEDID
list of all publications https://tinyurl.com/ycrqbf39   
Volckaert T, Yuan T, Chao CM, Bell H, Sitaula A, Szimmtenings L, El Agha E, Chanda D, Majka S, Bellusci S, et al. Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells. Dev Cell. 2017 Oct 9;43(1):48-59.e5. doi: 10.1016/j.devcel.2017.09.003.   29017029 
Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, et al. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. J Clin Invest. 2017 Jun 1;127(6):2262-2276. doi: 10.1172/JCI88629.  28463231 
El Agha E, Moiseenko A, Kheirollahi V, De Langhe S, Crnkovic S, Kwapiszewska G, Szibor M, Kosanovic D, Schwind F, Schermuly RT, et al. Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis. Cell Stem Cell. 2017 Feb 2;20(2):261-273.e3. doi: 10.1016/j.stem.2016.10.004.  27867035 
Volckaert T, Dill E, Campbell A, Tiozzo C, Majka S, Bellusci S, De Langhe SP. Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. J Clin Invest. 2011 Nov;121(11):4409-19. doi: 10.1172/JCI58097. Epub 2011 Oct 10.  21985786 
Volckaert T, Campbell A, Dill E, Li C, Minoo P, De Langhe S. Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development. 2013 Sep;140(18):3731-42. doi: 10.1242/dev.096560.   23924632 
Volckaert T, De Langhe SP. Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development. Dev Dyn. 2015 Mar;244(3):342-66. doi: 10.1002/dvdy.24234.  25470458 
Li C, Li M, Li S, Xing Y, Yang CY, Li A, Borok Z, De Langhe S, Minoo P. Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm. Stem Cells. 2015 Mar;33(3):999-1012. doi: 10.1002/stem.1911.  25448080 
Volckaert T, De Langhe S. Lung epithelial stem cells and their niches: Fgf10 takes center stage. Fibrogenesis Tissue Repair. 2014 May 8;7:8. doi: 10.1186/1755-1536-7-8. eCollection 2014.  24891877 
De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S. Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One. 2008 Jan 30;3(1):e1516. doi: 10.1371/journal.pone.0001516.  18231602 
 

Keywords
lung stem cells, lung fibrosis, lung development, lung regeneration