Cell, Molecular, & Developmental Biology  http://www.gbs.uab.edu  http://www.uab.edu/graduate  Back to Main

Faculty Detail    
Name KEITH GILES
Assistant Professor
Stem Cell Institute
 
Campus Address KAUL 502 Zip 0024
Phone  (20-5) -745
E-mail  kegiles@uab.edu
Other websites www.gileslab.com
     

Education
Undergraduate  SUNY Buffalo    1999  B.S. 
Graduate  The Johns Hopkins University     2004  PhD 
Fellowship  Laboratory of Molecular Biology, NIH/NIDDK    2011  Post-doctoral 


Faculty Appointment(s)
Appointment Type Department Division Rank
   

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Genetics, Genomics and Bioinformatics 

Biographical Sketch 
B.S. SUNY Buffalo 1999 PhD The Johns Hopkins University 2005 Post-Doctoral Fellowship The Laboratory of Molecular Biology at NIH/NIDDK



Research/Clinical Interest
Title
Transcripiton, Chromatin, and Pluripotentcy
Description
1) The regulation of transcription by chromatin, specifically uH2B 2) Noncoding RNA and higher-order chromatin structure 3) Ribosomal RNA synthesis and the regulation of pluripotency

Selected Publications 
Publication PUBMEDID
Packaging and reverse transcription of snRNAs by retroviruses may generate pseudogenes.

Giles KE, Caputi M, Beemon KL.

RNA. 2004 Feb;10(2):299-307.

PMID:14730028
 
14730028  
Solution structure of the pseudo-5' splice site of a retroviral splicing suppressor.

Cabello-Villegas J, Giles KE, Soto AM, Yu P, Mougin A, Beemon KL, Wang YX.

RNA. 2004 Sep;10(9):1388-98.

PMID:
15317975 
15317975 
Retroviral splicing suppressor sequesters a 3' splice site in a 50S aberrant splicing complex.

Giles KE, Beemon KL.

Mol Cell Biol. 2005 Jun;25(11):4397-405.

PMID:
15899846 
15899846 
Maintenance of a constitutive heterochromatin domain in vertebrates by a Dicer-dependent mechanism.

Giles KE, Ghirlando R, Felsenfeld G.

Nat Cell Biol. 2010 Jan;12(1):94-9; sup pp 1-6. doi: 10.1038/ncb2010. Epub 2009 Dec 13.

PMID:
20010811 
20010811 
Chromatin boundaries, insulators, and long-range interactions in the nucleus.

Giles KE, Gowher H, Ghirlando R, Jin C, Felsenfeld G.

Cold Spring Harb Symp Quant Biol. 2010;75:79-85. doi: 10.1101/sqb.2010.75.006. Epub 2010 Nov 3.

PMID:
21047907 
21047907 
USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

Zhang Z, Jones A, Joo HY, Zhou D, Cao Y, Chen S, Erdjument-Bromage H, Renfrow M, He H, Tempst P, Townes TM, Giles KE, Ma L, Wang H.

Genes Dev. 2013 Jul 15;27(14):1581-95. doi: 10.1101/gad.211037.112. Epub 2013 Jul 3.

PMID:
23824326
[PubMed - indexed for MEDLINE]

Free PMC Article 
23824326 
The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment.

Yang W, Lee YH, Jones AE, Woolnough JL, Zhou D, Dai Q, Wu Q, Giles KE, Townes TM, Wang H.

Nat Commun. 2014 May 2;5:3818. doi: 10.1038/ncomms4818.

PMID:
24784029
[PubMed - in process]

Related citations
Select item 238243262.

 
24784029 
Woolnough JL, Atwood, BL, Giles, KE. (2015). Argonaute 2 binds directly to tRNA genes and promotes and promotes gene repression in cis. Mol Cell Biol. July, 35:13:2278. PMID: 25918241  25918241 

Keywords
Argonatue, RNAi, insulator, nucleosomes