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Faculty Detail    
Name KEJIN HU
Assistant professor
PhD
 
Campus Address SHEL 705 Zip 2182
Phone  (20-5) -700
E-mail  kejinhu@uab.edu
Other websites Google Scholar
Webinar
     

Education
Graduate  The Hong Kong Polytechnic University    1997  MPhil 
Graduate  University of Hong Kong    2003  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Biochemistry & Molecular Genetics  Biochemistry & Molecular Genetics Assistant Professor
Center  Civitan International Research Center  Civitan International Research Center Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Genetics, Genomics and Bioinformatics 

Biographical Sketch 
Assistant professor in Stem Cell Biology since 2011; PhD in molecular biology from University of Hong Kong; MPhil in Biochemistry in microbiology from Hong Kong Polytechnic University; Postdoctoral training in muscle development using C. elegans as a model at Cornell University; Postdoctoral training in TOR signaling using budding yeast as a model at Pittsburgh University; Postdoctoral training in embryonic stem cell biology and reprogramming at University of Wisconsin-Madison.

Society Memberships
Organization Name Position Held Org Link
Genetics Society of America, GSA    http://www.genetics-gsa.org 
International Society for Stem Cell Research , ISSCR    http://www.isscr.org 



Research/Clinical Interest
Title
Molecular mechanisms of somatic cell reprogramming to pluripotency; self-renewal of pluripotent stem cells (PSC); Pluripotency; Epigenetics of PSC and reprogramming
Description
Molecular mechanisms of somatic cell reprogramming to pluripotency; self-renewal of pluripotent stem cells (PSC); Pluripotency; Epigenetics of PSC and reprogramming

Selected Publications 
Publication PUBMEDID
Kejin Hu. (2008). Homologous recombination and innocuous intron elimination. In Genetic Recombination Research Progress. Chapter 14, Pp. 323-333. Nova Science Publishers, Inc. ISBN: 978-1-6045-482-2   
Nirav M. Amin, Kejin Hu, David Pruyne, Dino Terzic, Anthony Bretscher & Jun Liu, (2007). A Zn-finger/FH2-domain containing protein, FOZI-1, acts redundantly with CeMyoD to specify striated body wall muscle fates in the Caenorhabditis elegans postembryonic mesoderm. Development, 134(1), 19-29.  17138663 
Nirav M. Amin, Kejin Hu, David Pruyne, Dino Terzic, Anthony Bretscher & Jun Liu, (2007). A Zn-finger/FH2-domain containing protein, FOZI-1, acts redundantly with CeMyoD to specify striated body wall muscle fates in the Caenorhabditis elegans postembryonic mesoderm. Development, 134(1), 19-29.  17138663 
Kejin Hu and Pak Chow Leung. (2007). Food digestion by cathepsin L and the digestion-related cell differentiation in shrimp hepatopancreas. Comparative Biochemistry and Physiology Part B, 146, 69-80.    
Kejin Hu, (2006). Intron exclusion and the mystery of intron loss. FEBS Letters, 580(27), 6361-6365.   17092501 
Kejin Hu & Pak Chow Leung, (2006). Complete, precise and innocuous loss of multiple introns in the currently intronless, active cathepsin L-like genes, and inference from this event. Molecular Phylogenetics and Evolution, 38, 685-696.
 
 
Ke-jin Hu, Pak-Chow Leung, (2004). Shrimp cathepsin L encoded by an intronless gene has predominant expression in hepatopancreas, and occurs in the nucleus of oocyte. Comparative Biochemistry and Physiology, Part B, 137(1), 21-33.    
Kran Suknuntha, Yuki Ishii, Kejin Hu, Jean Wang, Scott Swanson, Ron Stewart, James Thomson, Igor Slukvin. (2013) Induced pluripotent stem cell model of chronic myeloid leukemia revealed olfactomedin 4 as a novel therapeutic target in leukemia stem cells. Experimental Hematology, 41(8), S17.   
Kejin Hu, Kwok-Wing Yeung, Jinlian Hu, Kwok-ping Ho, (2004). Screening of fungi for chitosan producers, and copper adsorption capacity of fungal chitosan and chitosanaceous materials. Carbohydrate Polymers, 58 (1): 45-52.    
Ke-Jin Hu, Kwok-Wing Yeung, Kwok-Ping Ho, and Jin-lian Hu (1999). Rapid extraction of high-quality chitosan from mycelia of Absidia glauca, Journal of Food Biochemistry, 23, 187-196.   
Kejin Hu and Igor Slukvin (2013) Generation of transgene-free iPSC lines from human normal and neoplastic blood cells using episomal vectors. Methods in Molecular Biology, Pluripotent Stem Cells: Methods and Protocols. Vol. 997, pp. 163-176.   23546755 
Kejin Hu and Igor Slukvin (2013). Induction of pluripotent Stem cells from umbilical cord blood. Stem Cells: from biology to therapy. Vol. 1, Pp. 345-369.    
Kejin Hu and Igor Slukvin (2012) Induction of pluripotent Stem cells from umbilical cord blood. Encyclopedia of Molecular Cell Biology and Molecular Medicine: Stem Cells. 2nd edition, ed. Robert Meyers, Wiley-VCH, 1-25.    
Kejin Hu, Junying Yu, Kran Suknuntha, Shulan Tian, Karen Montgomery, Kyung-Dal Choi, Ron Stewart, James Thomson, Igor Slukvin, (2011). Efficient reprogramming of mononuclear cells from archived normal and neoplastic human bone marrow and cord blood with non-integrating episomal constructs. Blood, 117, e109-e119.  21296996 
Junying Yu, Kejin Hu, Kim Smuga-otto, Shulan Tian, Ron Stewart, Igor I Slukvin, James A Thomson, (2009). Human induced pluripotent stem cells free of vector and transgene sequences. Science, Vol. 324, 797-801  19325077 
Kejin Hu, (2014), Vectorology and factor delivery system in induced pluripotent stem cell reprogramming. Stem Cells and Development, 23(12): 1301-1315.   24625220 
Kejin Hu, (2014), All roads lead to induced pluripotent stem cells: the technologies of iPSC generation. Stem Cells and Development, 23(12) 1285-1300.
 
24524728 

Keywords
Reprogramming; embryonics stem cells; Induced pluripotent stem cells; pluripotency; epigenetics