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Faculty Detail    
Name NATALIA FILIPPOVA
 
Campus Address WTI 401E Zip 3300
Phone  (20-5) -544
E-mail  as1999@uab.edu
Other websites
     

Education
Graduate  Moscow State University    1992  master’s degree  
Graduate  Institute of Developmental Biology of Russian Academy Sciences    1995  Ph.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Neurology   Neurology Chair Office Instructor

Biographical Sketch 
Dr. Filippova, Ph.D., holds an Instructor position at the Department of Neurology, UAB, USA, since 2016. Dr. Filippova received training in neurobiology and electrophysiology in the INSERM U29, Paris, France and Bakulev Scientific Center for Cardiovascular Surgery, Moscow, Russia. Dr. Filippova has a masterís degree in Physics/Biophysics from Moscow State University, Russia and a Ph.D. in Biological Science from the Institute of Developmental Biology, Moscow, Russia. Dr. Filippova acquired expertise in neurophysiology and neuro-oncology from work at the Institute Pasteur, Paris, France and the University of Alabama at Birmingham, USA.



Research/Clinical Interest
Title
HuR oncogenic role in gliomas.
Description
Dr. Filippova has a broad background in neuro-oncology and neuroscience with specific training and expertise in i) characterization of the cellular kinome and cytoskeleton involved in GABA and Glutamate receptor regulation in normal and pathological conditions; ii) identification of cell-signaling pathways involved in centrosome abnormalities and genomic instabilities in the early stages of glioma development; iii) establishment of the drug discovery axis of post-translational modifications of the mRNA-binding protein HuR, whose up-regulation and multimerization are essential for brain tumor progression, iv) delineation of mechanisms of HuR protein multimerization and oncogenic function in gliomas; v) characterization of HuR role in cell fusion and tunneling nanotube formation leading to glioma heterogeneity; vi) establishment of the drug discovery axis of the PDL1 ligand regulation in the glioma microenvironment.

Selected Publications 
Publication PUBMEDID
N. Filippova* and L. B. Nabors ELAVL1 role in cell fusion and tunneling membrane tube formations with implication to glioma treatment. Cancers 2020, 12(10), 3069  DOI: 10.3390/cancers12103069 
N. Filippova, X. Yang, Z. An, L.B. Nabors, L. Pereboeva, Blocking PD1/PDL1 Interactions Together with MLN4924 Therapy is a Potential Strategy for Glioma Treatment, Journal of Cancer Science & Therapy. 10 (2018).   doi:10.4172/1948-5956.1000543 
N. Filippova, X. Yang, S. Ananthan, A. Sorochinsky, J.R. Hackney, Z. Gentry, et al., Hu antigen R (HuR) multimerization contributes to glioma disease progression, Journal of Biological Chemistry. 292 (2017) 16999–17010.   DOI: 10.1074/jbc.m117.797878 
N. Filippova, X. Yang, L. Nabors, Growth Factor Dependent Regulation of Centrosome Function and Genomic Instability by HuR, Biomolecules. 5 (2015) 263–281  DOI: 10.3390/biom5010263 
X. Han, W. Zhang, X. Yang, C.G. Wheeler, C.P. Langford, L. Wu, Filippova N. et al., The role of Src family kinases in growth and migration of glioma stem cells, International Journal of Oncology. 45 (2014), 302–310. doi:10.3892/ijo.2014.2432.   DOI: 10.3892/ijo.2014.2432 
N. Filippova, X. Yang, P. King, L.B. Nabors, Phosphoregulation of the RNA-binding Protein Hu Antigen R (HuR) by Cdk5 Affects Centrosome Function, Journal of Biological Chemistry. 287 (2012) 32277–32287.  DOI: 10.1074/jbc.m112.353912 
N. Filippova, X. Yang, Y. Wang, G.Y. Gillespie, C. Langford, P.H. King, et al., The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance, Molecular Cancer Research. 9 (2011) 648–659.   DOI: 10.1158/1541-7786.mcr-10-0325 
L. Lu, S. Wang, L. Zheng, X. Li, E.A. Suswam, X. Zhang, N. Filippova et al., Amyotrophic Lateral Sclerosis-linked Mutant SOD1 Sequesters Hu Antigen R (HuR) and TIA-1-related Protein (TIAR), Journal of Biological Chemistry. 284 (2009) 33989–33998.   DOI: 10.1074/jbc.m109.067918 
N. Filippova, V.E. Wotring, D.S. Weiss, Evidence that the TM1-TM2 Loop Contributes to the ρ1 GABA Receptor Pore, Journal of Biological Chemistry. 279 (2004) 20906–20914.   DOI: 10.1074/jbc.m401012200 
Filippova, N.; Sedelnikova, A.; Tyler, W. J.; Whitworth, T. L.; Fortinberry, H.; Weiss, D. S., Recombinant GABA(C) receptors expressed in rat hippocampal neurons after infection with an adenovirus containing the human rho1 subunit. The Journal of Physiology 2001, 535 (Pt 1), 145-53.   DOI: 10.1111/j.1469-7793.2001.00145.x 
Filippova, N.; Sedelnikova, A.; Zong, Y.; Fortinberry, H.; Weiss, D. S., Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C. Molecular Pharmacology 2000, 57 (5), 847-56.  PMID: 10779366 
Filippova, N.; Dudley, R.; Weiss, D. S., Evidence for phosphorylation-dependent internalization of recombinant human rho1 GABAC receptors. The Journal of Physiology 1999, 518 ( Pt 2), 385-99.   DOI: 10.1111/j.1469-7793.1999.0385p.x 
Medina, I.; Filippova, N.; Bakhramov, A.; Bregestovski, P., Calcium-induced inactivation of NMDA receptor-channels evolves independently of run-down in cultured rat brain neurones. The Journal of Physiology 1996, 495 ( Pt 2), 411-27.   DOI: 10.1113/jphysiol.1996.sp021603 
Medina, I.; Filippova, N *.; Charton, G.; Rougeole, S.; Ben-Ari, Y.; Khrestchatisky, M.; Bregestovski, P., Calcium-dependent inactivation of heteromeric NMDA receptor-channels expressed in human embryonic kidney cells. The Journal of Physiology 1995, 482 ( Pt 3), 567-73.   DOI: 10.1113/jphysiol.1995.sp020540 
Medina, I.; Filippova, N.; Barbin, G.; Ben-Ari, Y.; Bregestovski, P., Kainate-induced inactivation of NMDA currents via an elevation of intracellular Ca2+ in hippocampal neurons. Journal of Neurophysiology 1994, 72 (1), 456-65.   DOI: 10.1152/jn.1994.72.1.456 

Keywords
HuR, glioma heterogeneity, drug discovery, transcrptome profile, glioma microenvironment, tunneling tubes