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Faculty Detail    
Name NINA VANESSA KRAGULJAC
Associate Professor
Director, Psychiatry Resident Research Track
Interim Director Psychiatry ED Services
 
Campus Address SC 1006 Zip 0017
Phone  (205) 996-7574
E-mail  nkraguljac@uab.edu
Other websites
     

Education
Graduate  Paris Lodron University    2006  M.A. Psychology 
Medical School  Paracelsus Medical University    2008  M.D. 
Residency  University of Alabama at Birmingham    2013  Psychiatry 


Faculty Appointment(s)
Appointment Type Department Division Rank
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Associate Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor
Primary  Psychiatry   Psych - Behavioral Neurobiology Associate Professor

Society Memberships
Organization Name Position Held Org Link
American College of Neuropsychopharmacology     
American Medical Association     
American Psychiatric Association     
Medical Association of the State of Alabama     



Selected Publications 
Publication PUBMEDID
Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB. Neuroimaging biomarkers in schizophrenia, American Journal of Psychiatry, in press   33397140 
Goodman AM, Allendorfer JB, Baird G, Blum AS, Bolding M, Correia S, ver Hoef L, Gaston T, Grayson L, Kraguljac NV, Lahti AC, Martin AN, Monroe WS, Phillip NS, Skidmore F, Tocco K, Vogel V, LaFrance C, Szaflarski JP. White matter integrity and neurite morphology in psychogenic non-epileptic seizures following TBI, Annals of Clinical and Translational Neurology, 2020 Oct;7(10):1973-1984   32991786 
Gawne TJ, Overbeek GJ, Killen JF, Reid MA, Kraguljac NV, Denney TS, Ellis CA, Lahti AC. A multimodal magnetoencephalography, 7T fMRI Stroop, and 7T Proton MR Sepectroscopy study in first episode psychosis, npj schizophrenia, 2020: 4: 23   32887887 
Nelson EA, Kraguljac NV, Maximo JO, Briend F, Armstrong WP, Johnson V, Lahti AC. Hippocampal dysconnectivity and altered glutamatergic modulation of the default mode network – a combined resting state connectivity and magnetic resonance spectroscopy study in schizophrenia, Biological Psychiatry:CNNI, 2020: 5: 231-238   32684484 
Kraguljac NV, Anthony T, Morgan CJ, Jindal RD, Burger MS, Lahti AC. White matter integrity, duration of untreated psychosis, and antipsychotic treatment response in medication-naïve first episode psychosis patients, Molecular Psychiatry, in press   32398721 
Briend F, Kraguljac NV, Nelson EA, Armstrong WP, Maximo JO, Lahti AC. Hippocampal glutamate and hippocampus subfield volumes in antipsychotic-naïve first episode psychosis subjects and relationships to duration of untreated psychosis, Translational Psychiatry, 2020, 10: 137   32398671 
Bruns DP, Kraguljac NV, Bruns TR. COVID-19 – Facts, cultural considerations, and risk of stigmatization. Journal of Transcultural Nursing, 2020, 4: 326-332   32316872 
Briend F, Armstrong WP, Kraguljac NV, Keilholz S, Lahti AC. Aberrant static and dynamic functional patterns of fronto-parietal control network in antipsychotic-naïve first episode psychosis subjects, Human Brain Mapping, 41: 2999-3008   32372508 
Gurler D, White DM, Kraguljac NV, Ver Hoef L, Martin C, Tennant B, Lahti AC. Neural signatures of memory encoding in schizophrenia are modulated by antipsychotic treatment, Neuropsychobiology, 2020, 21: 1-13   32316023 
Reddy-Thootkur M, Kraguljac NV, Lahti AC. The role of glutamate and GABA in cognitive dysfunction in schizophrenia and mood disorders – a systematic review of magnetic resonance spectroscopy studies, Schizophrenia Research, in press   32107102 
Nelson EA, Kraguljac NV, White DM, Jindal RD, Shin AL, Lahti AC. A prospective longitudinal investigation of cortical thickness and gyrification in schizophrenia, Canadian Journal of Psychiatry, 2020, 65: 381-391   32022594 
Birur B, Kraguljac NV, VerHoef LW, Jindal RD, Reid MA, Luker A, Lahti AC. Neurometabolic correlates of six and sixteen weeks of treatment with risperidone in medication-naïve first episode psychosis patients, Translational Psychiatry, 2020, 10: 15   32066680 
Maximo JO, Nelson EA, Armstrong WP, Kraguljac NV, Lahti AC. Duration of untreated psychosis correlates with brain connectivity and morphology in medication-naïve patients with first episode psychosis, Biological Psychiatry: CNNI, 2020, 5: 231-238   31902581 
Bryant JE, Froelich MA, Tran S, Reid MA, Lahti AC, Kraguljac NV. Ketamine induced changes in regional cerebral blood flow, metabolic connectivity and glutamate metabolism, Journal of Psychiatric Research, 2019, 117: 108-115   31376621 
Lottman KK, Gawne TJ, Kraguljac NV, Killen JF, Reid MA, Lahti AC. Examining resting-state functional connectivity in first episode schizophrenia with 7T fMRI and MEG, Neuroimage:Clinical, 2019, 24: 101959   31377556 
Froelich MA, White DM, Kraguljac NV, Lahti AC. Brain network connectivity prospectively predicts memory impairment following midazolam in older adults, Anesthesia & Analgesia, 2020, 130: 224-232   31498189 
Kraguljac NV, Anthony T, Monroe WS, Skidmore FM, Morgan CJ, White DM, Patel N, Lahti AC. A longitudinal neurite and free water imaging study in patients with a schizophrenia spectrum disorder, Neuropsychopharmacology, 2019, 44(11): 1932-1939   31153156 
Kraguljac NV, Morgan CJ, Reid MA, White DM, Jindal RD, Sivaraman S, Martinak B, Lahti AC. A longitudinal magnetic resonance spectroscopy study investigating effects of risperidone in the anterior cingulate cortex and hippocampus in schizophrenia, Schizophrenia Research, 2019, 210: 239-244   30630705 
Kraguljac NV, Anthony T, Skidmore FA, Marstrander J, Morgan CJ, Reid MA, White DM, Jindal RD, Skefos NHM, Lahti AC. Micro- and macrostructural white matter integrity in never-treated and currently unmedicated patients with schizophrenia and effects of short term antipsychotic treatment, Biological Psychiatry:CNNI, 2019, 4(5): 462-471   30852126 
Overbeek, G, Gawne TJ, Reid MA, Salibi N, Kraguljac NV, White DM, Lahti AC. Relationship between cortical excitation and inhibition and task-induced activation and deactivation: A combined MR Spectroscopy and functional MRI study at 7T in first episode psychosis, Biological Psychiatry: CNNI, 2019, 4(2): 121-130   30470582 
Cadena EJ, White DM, Kraguljac NV, Reid MA, Jindal R, Pixley RM, Lahti AC. Cognitive control network dysconnectivity and response to antipsychotic treatment in schizophrenia, Schizophrenia Research, 2019, 204: 262-270   30098853 
Nelson EA, White DM, Kraguljac NV, Lahti AC. Gyrification connectomes in unmedicated patients with schizophrenia and following a short course of antipsychotic treatment, Frontiers in Psychiatry, 2018, 9: 699   30618873 
Cadena EJ, White DM, Kraguljac NV, Reid MA, Gawronski BA, Lahti AC. A longitudinal multimodal neuroimaging study to examine relationships between resting state glutamate and task related BOLD response in schizophrenia, Frontiers in Psychiatry, 2018, 9: 632   30555359 
Sivaraman S, Kraguljac NV, White DM, Morgan CJ, Gonzales SS, Lahti AC. Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients, Psychiatry Research: Neuroimaging, 2018, 281: 101-106   30286325 
Cadena EJ, White DM, Kraguljac NV, Reid MA, Lahti AC. Evaluation of fronto-striatal network during cognitive control in unmedicated patients with schizophrenia and effect of antipsychotic medication, NPJ Schizophrenia, 2018, 4(1): 8   29736018 
Lottman KK, White DM, Kraguljac NV, Reid MA, Calhoun VD, Catao F, Lahti AC. Four-way multimodal fusion of 7T imaging data using mCCA+jICA model in first episode schizophrenia. Human Brain Mapping, 2018, 39(4): 1475-1488   29315951 
Kraguljac NV, Lahti AC. Paving the way towards targeted drug development in schizophrenia. JAMA Psychiatry, 2018, 75(1):19-20   29167884 
Kraguljac NV, Carle M, Frolich MA, Tran S, Yassa MA, White DM, Reddy A, Lahti AC. Mnemonic discrimination deficits in first episode psychosis and a ketamine model suggests dentate gyrus pathology linked to NMDA-receptor hypofunction, Biological Psychiatry:CNNI, 2018, 3(3): 231-238   29486864 
Birur B, Kraguljac NV. A rare presentation of auto-emasculation in a patient with schizoaffective disorder: management with clozapine, Clinical Schizophrenia and Related Psychoses, in press   28777030 
Birur B, Kraguljac NV, Shelton RC, Lahti AC. Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder – a systematic review of the magnetic resonance neuroimaging literature, npj Schizophrenia, 2017, 3: 15   28560261 
Lottman KK, Kraguljac NV, White DM, Morgan CJ, Calhoun VD, Butt A, Lahti AC. Risperidone effects on brain dynamic connectivity – a prospective resting state fMRI study in schizophrenia, Frontiers Psychiatry, 2017, 6;8: 14   28220083 
Kraguljac NV, Frölich MA, Tran S, White DM, Nichols N, Barton-McArdle A, Reid MA, Bolding MS, Lahti AC. Ketamine modulates hippocampal neurochemistry and functional connectivity – a combined magnetic resonance spectroscopy and resting state fMRI study in healthy volunteers, Molecular Psychiatry, 2017, 22 (4):562-569
 
27480494 
Hammond JC, Lahti AC, Kraguljac NV. Rapid clozapine titration in an acutely agitated patient with schizoaffective disorder: a case report, Journal of Clinical Psychopharmacology, 2016, 36 (3): 276-277   26981924 
Hadley JA, Kraguljac NV, White DM, Ver Hoef LW, Tabora J, Lahti AC. Change in brain network topology as a function of treatment response in schizophrenia - a longitudinal resting state fMRI study using graph theory, npj Schizophrenia, 2016, 2: 16014   26878032 
Kraguljac NV, White DM, Hadley N, Hadley JA, Ver Hoef LW, Davis E, Lahti AC. Aberrant hippocampal circuitry in unmedicated patients with schizophrenia and effects of antipsychotic medication: a longitudinal resting state functional MRI study, Schizophrenia Bulletin, 2016, 42 (4):1046-55   26873890 
Reid MA, White DM, Kraguljac NV, Lahti AC. A combined diffusion tensor imaging and magnetic resonance spectroscopy study of patients with schizophrenia, Schizophrenia Research, 2016, 170(2-3): 215-50   26718333 
Kraguljac NV, White DM, Hadley JA, Visscher KM, Knight DC, Ver Hoef LW, Falola B, Lahti AC. Abnormalities in large scale functional networks in unmedicated patients with schizophrenia and effects of risperidone. NeuroImage: Clinical, 2015, 10: 146-158   26793436 
White DM, Kraguljac NV, Reid MA, Lahti AC. Contribution of substantia nigra glutamate to prediction error signals in schizophrenia: a combined magnetic resonance spectroscopy/ functional imaging study. npj Schizophrenia, 2015, 1: 14001   26878032 
Kraguljac NV, White DM, Hadley JA, Reid MA, Lahti AC. Hippocampal-parietal dysconnectivity and glutamate abnormalities in unmedicated patients with schizophrenia. Hippocampus, 2014, 24(12): 1524-32   25045047 
Kraguljac NV, Cutter GR, Morgan C, Lahti AC. The problem or spurious correlations between pairs of brain metabolite values measured in the same voxel with MRS, JAMA Psychiatry, 2014, 71(3): 339-40   24599245 
Hadley J.A., Nenert R., Kraguljac N.V., Bolding M.S., White D.M., Skidmore F.M., Visscher K.M., Lahti A.C. Ventral Tegmental Area/Midbrain Functional Connectivity and Response to Antipsychotic Medication in Schizophrenia. Neuropsychopharmacology, Oct. 29, 2013  24165885 
Kraguljac, N.V., White, D.M., Reid, M.A., Lahti, A.C. Increased Hippocampal Glutamate and Volumetric Deficits in Unmedicated Patients With Schizophrenia. JAMA Psychiatry, Oct. 9, 2013   24108440 
Reid M.A., Kraguljac N.V., Avsar K.B., White D.M., den Hollander J.A., Lahti A.C. Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia. Schizophrenia Research. 2013 Jul;147(2-3):348-54  23706412 
Kraguljac N.V., Srivastava A., Lahti A.C. Memory Deficits in Schizophrenia: A Selective Review of Functional Magnetic Resonance Imaging (fMRI) Studies. Behavioral Sciences. 2013; 3(3):330-347   
Kraguljac N.V., Reid M.A., White D.M., den Hollander J., Lahti A.C. Regional decoupling of N-acetyl-aspartate and glutamate in schizophrenia. Neuropsychopharmacology. 2012 Nov;37(12):2635-42  22805603 
Kraguljac, N.V., Reid, M.A., White, D.M., Jones, R., den Hollander, J.A., Lowman, D.K., and Lahti, A.C. Neurometabolites in Schizophrenia and Bipolar - A Systematic Review and Metaanalysis. Psychiatry Research: Neuroimaging, 203(2-3): 111-25. 2012  22981426 
Hutcheson, N.L., Reid, M.A., White, D.M., Kraguljac, N.V., Avasar, K.B., Bolding, M.S., Knowlton, R.C., den Hollander, J.A., and Lahti, A.C. Multimodal Analysis of the Hippocampus in Schizophrenia using Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging. Schizophrenia Research, 140(1-3): 136-42.   22831772 
Kraguljac N.V., Montori V.M., Pavuluri M., Chai H.S., Wilson B.S., Unal S.S. Efficacy of omega-3 fatty acids in mood disorders - a systematic review and metaanalysis. Psychopharmacol Bull. 2009;42(3):39-54  19752840