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Faculty Detail    
David H. Chestnut Professor of Anesthesiology
Director, Division of Critical Care Medicine
Vice Chair, Department of Anesthesiology
Professor, Department of Surgery
Professor, Department of Cell, Developmental and Integrative Biology
Investigator, Center for Lung Injury and Repair
Campus Address JT 926 Zip 6810
Phone  (20-5) -755
Other websites

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Anesthesiology   Anesthesiology Chair Office Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Secondary  Surgery   Surgery - Gen Surg Trauma Section Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor

Biographical Sketch 
Education and Degrees •University of Lausanne, Lausanne, Switzerland, M.D., 1977 •Champittet College, Lausanne, Switzerland, B.A., 1970 Awards and Honors •3rd Award, Swiss Society of Surgery, 1989 •2nd Award, 3rd International Steglitzer Symposium, 1989 •1st Award, Swiss Society of Critical Care Medicine, 1990 •Elected to American Thoracic Society, 1994 •Elected to American Physiological Society, 1994 •Prospective Award, International Anesthesia Trauma and Critical Care Society, 1995

Society Memberships
Organization Name Position Held Org Link
American Physiological Society     
American Society of Anesthesiologists     
American Society of Critical Care Medicine     
American Thoracic Society     
Association of University Anesthesiologists     
California Society of Anesthesiologists     
California Thoracic Society     
European Society of Intensive Care Medicine     
European Surgical Infection Society     
FAER Academy of Research Mentors in Anesthesiology     

Research/Clinical Interest
Anesthesiology; Critical Care; and Perioperative Medicine

Selected Publications 
Publication PUBMEDID
Wagener BM, Roux J, Carles M, Pittet JF. Synergistic Inhibition of beta2-adrenergic Receptor-mediated Alveolar Epithelial Fluid Transport by Interleukin-8 and Transforming Growth Factor-beta. Anesthesiology. Epub Jan 2015.  25591042 
Carles M, Wagener BM, Lafargue M, Roux J, Iles K, Liu D, Rodriguez CA, Anjum N, Zmijeski J, Ricci JE, Pittet JF. Heat-shock response increases lung injury caused by Pseudomonas aeruginosa via an interleukin-10-dependent mechanism in mice. Anesthesiology 120(6):1450-62, 2014.  24667831 
Pittet JF, Koh H, Fang X, Iles K, Christiaans S, Anjun N, Wagener BM, Park DW, Zmijewski JW, Matthay MA, Roux J. HMGB1 accelerates alveolar epithelial repair via an IL-1 beta- and alphav-beta6 integrin-dependent activation of TGF-beta 1. PLoS One 8(5), 2013.  23696858 
Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF. IL-8 Inhibits cAMP-stimulated Alveolar Epithelial Fluid Transport via a GRK2/PI3K-dependent Mechanism. FASEB J 2013 27(3):1095-106, 2012  23221335 
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA 313(5):471-82, 2015.  25647203 
Lafargue M, Xu L, Carlès M, Serve E, Anjum N, Iles KE, Xiong X, Giffard R, Pittet JF. Stroke-induced activation of the alpha7 nicotinic receptor increases Pseudomonas aeruginosa lung injury. FASEB J 26(7):2919-2929, 2012.  22490926  
Bir N, Lafargue M, Howard M, Goolaerts A, Roux J, Carles M, Cohen MJ, Iles KE, Fernandez JA, Griffin JH, Pittet JP. Cytoprotective-selective Activated Protein C Attenuates P. aeruginosa-induced Lung Injury in Mice. Am J Respir Cell Mol Biolog 45(3):632-41, 2011.  21257925 
Whittaker B, Christiaans SC, Altice JL, Chen MK, Alfred BA, Morgan CJ, Kerby JD, Pittet JF. Early coagulopathy is an independent predictor of mortality in children after severe trauma. Shock 39(5):421-26, 2013.  3591559 
Goolaerts A, Lafargue M, Song Y, Miyazawa B, ArjomandI M, Carlès M, Roux J, Howard M, Parks DA, Iles KE, Pittet JF. PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice. Thorax 66(9):788-96, 2011.  21768189  
Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg, 255:379-85, 2012.  20938335 
Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin alphav-beta8-mediated activation of TGF-beta;. J Clin Invest. 121(7): 2863-2875, 2011.  21646718 
Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, and Cohen MJ. Active and Passive Cigarette Smoking and Acute Lung Injury Following Severe Blunt Trauma. Am J Respir Crit Care Med 183(12):1660-5, 2011.  21471091 
Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, Christie JD. ANGPT2 Genetic Variant is Associated with Trauma-Associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio. Am J Respir Crit Care Med 183: 1344-1353, 2011.   21257790 
Cohen MJ, Carles M, Brohi K, Calfee CS, Rahn P, Call MS, Chesebro BB, West MA, Pittet JF. Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans. J Trauma 68(6):1273-1278, 2010.  20539169 
Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND, Pittet JF. Angiopoietin-2, Marker and mediator of endothelial activation with prognostic significance early after trauma? Ann Surg 247:320-326, 2008.  18216540