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Faculty Detail    
Name FARAH D LUBIN
Associate Professor		  
Campus Address SHEL 1102 Zip 2182
Phone  (20-5) -084
E-mail  flubin@uab.edu
Other websites www.lubinlab.com
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Neurobiology  Neurobiology Associate Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Center  Neurology   Alzheimer's Disease Center Associate Professor
Center  Civitan International Research Center  Civitan International Research Center Associate Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Associate Professor
Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Associate Professor
Center  Neurology   Evelyn F. McKnight Brain Institute Associate Professor
Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Associate Professor
Center  Integrative Center for Aging Research  Integrative Center for Aging Research Associate Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Genetics, Genomics and Bioinformatics 
Neuroscience 

Biographical Sketch 
www.lubinlab.com Dr. Lubin received her undergraduate degree from Alabama State University in Montgomery, Alabama and her Ph.D. in Cell/Molecular Biology and Immunology from Binghamton University in Binghamton, New York. She has also worked as a research assistant at Memorial Sloan Kettering Cancer Center in New York. Dr. Lubin has completed two postdoctoral fellowships in Molecular Neuroscience at Baylor College of Medicine in Houston, Texas and most recently in the Department of Neurobiology at UAB. Dr. Lubin is a recipient of a Pathway to Independence Award from the National Institutes of Health (NIH/NIMH) and FASEB Award. She has coauthored numerous publications in various scientific journals. Her most recent publications in J. Neuroscience and Neuron gives insight not only into the cellular and molecular mechanisms underlying long-term memory, but also insights into the fundamental mechanisms that might be deranged in cognitive disorders. Dr. Lubin’s research is primarily directed towards characterizing the role of epigenetic mechanisms and signaling cascades that mediate the interaction of the NF-kB transcription factors to chromatin, and determining how they participate in the regulation of gene expression as they relate to learning and memory.



Research/Clinical Interest
Title
Molecular genetic mechanisms in learning and memory
Description
Dr. Lubin’s research interest is focused on understanding the cellular and molecular mechanisms underlying transcriptional regulation of genes in the nervous system to mediate cognition and how these mechanisms are altered with aging and cognitive disorders including epilepsy and Alzheimer’s disease. Currently, our research is directed at characterizing the role of epigenetic mechanisms, such as histone modifications, DNA methylation, and the interaction of the NF-kB signaling pathway with chromatin to determine how these molecular changes participate in the regulation of gene expression related to the normal process of learning and memory and how they are deranged with cognitive deficits.

Keywords
Epigenetics, NF-kappa B signal transduction, gene transcription, neuroscience, learning and memory, epilepsy