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Faculty Detail    
Name RUI-MING LIU
 
Campus Address THT 541C Zip 0006
Phone  (20-5) -028
E-mail  rliu@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Pulmonary/Allergy/Critical Care Professor
Secondary  Environmental Health Sciences  Environmental Health Sciences Professor
Secondary  Mechanical Engineering  Mechanical Engineering Associate Professor
Secondary  Medicine  Med - Pulmonary/Allergy/Critical Care Associate Professor
Secondary  Pharmacology/Toxicology   Pharmacology/Toxicology Chair's Office Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor
Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor

Graduate Biomedical Sciences Affiliations
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Neuroscience 
Pathobiology and Molecular Medicine 

Biographical Sketch 
1983- B.S. (Medicine), Wuhan Medical University, Wuhan, China 1989- Ph. D., Environ. Toxicology, Tongji Medical University, Wuhan, China 1989-1991: Assistant Professor, Dept. Environ. Toxicol., Tongji Medical University, China 1991-1993: Postdoctoral Fellow, Dept. Environ. Health, University of Cincinnati 1993-1996: Research Associate, Dept. Mol. Pharm. & Toxicol., University of Southern California 1996-1999: Research Assistant Professor, Dept. Mol. Pharm. & Toxic., University of Southern California 1999-2005: Assistant Professor, Dept. Environ. Health Sciences, School of Public Health, University of Alabama at Birmingham (UAB) 2005-present : Associate Professor, Dept. of Environ. Health Sciences, School of Public Health, UAB 1999-present Scientist, Centre for Aging, UAB 2000-present Associate Scientist, Cancer Centre, UAB

Society Memberships
Organization Name Position Held Org Link
American Federation for Aging Research     
Society of Free Radical in Biology and Medicine     
Society of Toxicology     



Research/Clinical Interest
Title
Description
Oxidative stress contributes importantly to the pathogenesis of many diseases and aging. The research in my lab focuses on the role of oxidative stress in the development of lung fibrosis fibrotic and neurodegenerative diseases, the underlying mechanism, and the potential therapeutic value of antioxidants in the treatment of these diseases.

Selected Publications 
Publication PUBMEDID
1. Liu, R-M., Choi, J., Wu, J., Lewis, K., Reyes deRogers, NS., Ballinger, C., Brand, JD., Krzywanski, D., Hagood, J., Forman, HJ., Thannickal, V., and Postlethwait, EM. (2010). Oxidative modification of nuclear mitogen activated protein kinases phosphatase 1 is involved in transforming growth factor beta 1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J of Biol. Chem. 285 (21): 16239-47

2. Liu, R-M and Gaston Pravia, K.A (2010). Oxidative Stress, Glutathione, and Transforming Growth Factor beta-mediated Fibrogenesis. Free Radic Biol Med. 48 (1): 1–15.

3. Liu, R-M., van Groen, T., Katre, A., Cao, D., Kadish, I., Ballinger, C., Li, J., Wang, L., Carroll, S. L., and Li, L. (2009). Knockout of the plasminogen activator inhibitor 1 gene reduces cerebral amyloid beta peptide burden in a mouse model of Alzheimer’s disease. Neurobiology of Aging (online publication). NIHMS:125286

4. Liu, R-M (2008). Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis. Antioxidants & Redox Signaling 10 (2): 303-319.

5. Vayalil, PK. Iles, KE. Choi, J. Yi, Ae-Kyung., Postlethwait, EM. Liu, R-M. (2007). Glutathione suppresses TGF-beta-induced plasminogen activator inhibitor-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter. Am. J. Physiology. Lung Cell. Mol. Physiol. 293: L1281-L1292.

6. Li, M., Liu, R-M., Timblin, C. R., Meyer, S. G., Mossman, B. T., and Fukagawa, N. K. (2006). Age affects ERK1/2 and Nrf2 signaling in the regulation of GCLC expression. J Cellular Physiology 206(2); 518-525.

7. Zhang, H., Liu, H., Dickinson, D.A., Liu, R-M., Postlethwait, E., Laperche, L., and Forman, H.J (2006). Gamma-glutamyl transpeptidase is induced by HNE via EpRE in rat epithelial type II cells. Free Radic Biol Med. 40: 1281-1292.

8. Zhang, H., Liu, H., Iles, K. E., Liu, R-M., Postlethwait, E., Laperche, L., and Forman, H.J (2006). 4-Hydroxynonenal induced rat GGT promoter 5 activity through MAPK mediated EpRE signaling. Am. J. Respir. Cell Mol. Biol. 34(2):174-81.

9. Vayalil, P.K., Olman, M., Postlethwait, E.M., Murphy-Ullrich, J., and Liu, R-M (2005). Glutathione restores collagen degradation in TGF beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expressionand activating plasminogen. Am. J. Physiology. (Lung Cell. Mol. Physiol). 289:L937-L945.

10. Iles, K. E. and Liu, R-M (2005). Mechanisms of Glutamate Cysteine Ligase Induction by 4-Hydroxynonenal. Free Radical Biology & Medicine 38: 547-556.

11. Zhang, H., Dickinson, D.A., Liu, R-M., Forman, H.J. (2005). 4-Hydroxynonenal increases gamma-glutamyl transpeptidase gene expression through mitogen activated protein kinases pathways. Free Radical Biology & Medicine 38: 463-471.

12. Liu, H., Harrell, L.E., Shenvi, S., Hagen, T., and Liu, R-M (2005). Gender Differences in Glutathione Metabolism in Alzheimer’s Disease. J. Neuroscience Research 79(6): 861-867.

13. Suh, J. H., Shenvi, S. V., Dixon, B. M., Liu, H., Jaiswal, A.K., Liu, R-M., and Hagen, T. (2004). Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proceedings of the National Academy of Sciences. U.S.A. 101 (10); 3381-3386.

14. Liu, H., Wang, H., Shenvi, S., Hagen, T.M., and Liu, R-M. (2004). Glutathione metabolism during aging and in Alzheimer’s disease. Annals of the New York Academic Sciences Ann. N. Y. Acad. Sci.1019: 346-349.

15. Krzywanski, D. M., Dickinson, D. A., Iles, K. E., Wigley, A.F., Franklin, C. C., Liu, R-M., Kavanagh, T. J., and Forman, H. J. (2004). Variable Regulation of Glutamate Cysteine Ligase Subunit Proteins Affects Glutathione Biosynthesis in Response to Oxidative Stress. Archives of Biochem. Biophy. 423: 116-125.

16. Suh, J. H., Wang, H., Liu, R-M., Liu J-K., and Hagen T. M. (2004). (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch. Biochem. Biophy. 423:126-135.

17. Liu, R-M., Liu, Y., Forman, H. J., Olman, M., and Tarpey, M. (2004). Glutathione Regulates Transforming Growth Factor beta Stimulated Collagen Production in Fibroblasts. Am. J. Physiology. (Lung Cell. Mol. Physiol), 286 (1), L121-l128.

18. Liu, R-M. and Dickinson, D. A. (2003). Decreased Synthetic Capacity Underlies The Age-associated decline in glutathione content In Fisher 344 rats. Antioxidants & Redox Signaling 5(5): 529-536.

19. Wang H., Liu, H., and Liu, R-M. (2003). Gender difference in glutathione metabolism during aging in mice. Exp. Gerontology 38(5). 507-517.

20. Liu R-M (2002). Down regulation of gamma-glutamylcysteine synthetase regulatory subunit in rat brain during aging. Journal of Neuroscience Research 68:344-351.

21. Liu, R-M., Borok, Z., and Forman, H. J (2001). 4-Hydroxy-2-nonenal increases gamma-glutamylcysteine synthetase gene expression in alveolar epithelial type II cells. Am. J. Respir. Cell Mol. Biol. 24:499-505.

22. Jha, N., Jurma, O., Lalli, G., Liu, Y., Pettus, E. H., Greenamyre, J. T., Liu, R-M., Forman, H. J., and Andersen, J. .K (2000). Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity: implications for Parkinson's disease. J. Biol. Chem. 275 (34): 26096-26101.

23. Liu, R-M., and Choi, J (2000). Age-associated decrease in gamma-glutamylcysteine synthetase gene expression in Fisher 344 rats. Free Radical Biology & Medicine 28(4): 566-574.

24. Choi, J., Liu, R-M., Kundu, RK., Sangiorgi, F., Wu, W., Maxson, R., and Forman, HJ (2000). Molecular mechanism of decreased glutathione content in Human Immunodeficiency Virus Type 1 Tat-Transgenic mice. J. Biol. Chem. 275(5): 3693-8.
 
 

Keywords
Oxidative stress, Aging, Lung fibrosis, Alzheimer's disease