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Faculty Detail    
Name OLAF KUTSCH
 
Campus Address BBRB 510 Zip 2170
Phone  (20-5) -547
E-mail  okutsch@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Infectious Diseases Professor
Secondary  Microbiology  Microbiology Assistant Professor
Center  Center for AIDS Research  Center for AIDS Research Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 

Biographical Sketch 
1989-1991 Prediploma Fellow, Institute for Biotechnology, University of Würzburg, Germany 1992-1997 Predoctoral Fellow, Institute for Immunobiology, University of Würzburg, Germany 1998-2001 Postdoctoral Fellow, University of Alabama at Birmingham 2001-2003 Research Instructor, University of Alabama at Birmingham 2003-2005 Research Assistant Professor, University of Alabama at Birmingham 2005- 2008 Assistant Professor, University of Alabama at Birmingham 2005-present Associate Scientist, UAB CFAR 2007-present Director UAB CFAR Flow Cytometry Core Facility 2008-present Associate Professor, University of Alabama at Birmingham



Research/Clinical Interest
Title
Associate Professor
Description
HIV-1 research in my laboratory is focused on finding a cure for HIV-1 infection. This goal is pursued at the level of basic research and drug discovery. Basic research efforts focus on advancing our understanding of the molecular mechanisms controlling latent HIV-1 infection. The insights gained from these studies can then be translated into drug discovery efforts, either by developing drug screening assays and performing drug screens, or by trying to reposition existing drugs.

Selected Publications 
Publication PUBMEDID
Selected Drugs with Reported Secondary Cell-Differentiating Capacity Prime Latent HIV-1 Infection for Reactivation.
Shishido T, Wolschendorf F, Duverger A, Wagner F, Kappes J, Jones J, Kutsch O.
J Virol. 2012 Sep;86(17):9055-69
 
22696646 
Shishido T, Wolschendorf F, Duverger A, Wagner F, Kappes J, Jones J, Kutsch O. Selected Drugs with Reported Secondary Cell-Differentiating Capacity Prime Latent HIV-1 Infection for Reactivation.
J Virol. 2012 Sep;86(17):9055-69. 
22696646 
Hit-and-run stimulation: a novel concept to reactivate latent HIV-1 infection without cytokine gene induction.
Wolschendorf F, Duverger A, Jones J, Wagner FH, Huff J, Benjamin WH, Saag MS, Niederweis M, Kutsch O.
J Virol. 2010 Sep;84(17):8712-20

 
20538859 
Determinants of HIV-1 latency establishment.
Duverger A, Jones J, May J, Bibollet-Ruche F, Wagner FA, Cron RQ, Kutsch O.
J Virol. 2009 Jan 14 
19144703 
Nef-mediated suppression of T cell activation is a fundamental property of primate lentiviruses.
Schindler, M., Münch, J., Kutsch, O., Li, H., Santiago, M.L., Bibollet-Ruche, F., Müller-Trutwin, M.C., Novembre, F.J., Peeters, M., Courgnaud, V., Bailes, E., Roques, P., Sondora, D.L., Sharp, P.M., Hahn, B.H., and Kirchhoff, F.
Cell 2006 Jun 16;125(6):1055-67
 
16777597 
Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription.
Kutsch O, Levy DN, Bates PJ, Decker J, Kosloff BR, Shaw GM, Priebe W, Benveniste EN.
Antimicrob Agents Chemother. 2004 May;48(5):1652-63. 
15105117 
Dynamics of HIV-1 recombination in its natural target cells.
Levy DN, Aldrovandi GM, Kutsch O, Shaw GM.
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4204-9. 
15010526 
Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latency.
Kutsch O, Benveniste EN, Shaw GM, Levy DN.
J Virol. 2002 Sep;76(17):8776-86.
 
12163598 

Keywords
HIV-1 eradication, HIV-1 latency, drug discovery