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Faculty Detail    
Name LARISA PEREBOEVA
 
Campus Address CHB 100
Phone  (20-5) -082
E-mail  larisa.pereboeva@ccc.uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pediatrics   Ped - Infectious Disease Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor



Research/Clinical Interest
Title
Cellular vehicles for cancer therapy Design of adenoviral vectors with modified tropism
Description
My research interests are in developing a cell-based delivery of anticancer therapeutics to tumors. Specifically, mesenchymal stem/progenitor cells (MSCs) are exploited as carriers to deliver suicide/therapeutic/ genes as well as oncolytic viruses to tumors. MPS-based delivery of anti-cancer therapeutics to tumors capitalizes on interesting property of this cell population to home to the sites of tissue injury and tumors. Major efforts are concentrated on testing feasibility and efficacy of using these and other cell types as vehicles, investigating advantages of cell-based delivery of therapeutics and to increase an efficiency of cell- based delivery via influencing cell homing to tumors through engineered cell targeting. Other interests are in genetic modification of adenoviral vectors by constructing fiber-mosaic adenoviruses for expanding virus tropism or introducing novel properties to adenoviral particles

Selected Publications 
Publication PUBMEDID
Pereboeva LA, Pereboev AV, Morris GE. Identification of antigenic sites on three hepatitis C virus proteins using phage-displayed peptide libraries. J Med Virol. 1998 Oct;56(2):105-11.  9746064  
Tsuruta Y, Pereboeva L, Breidenbach M, Rein DT, Wang M, Alvarez RD, Siegal GP,Dent P, Fisher PB, Curiel DT. A fiber-modified mesothelin promoter-based conditionally replicating adenovirus
for treatment of ovarian cancer. Clin Cancer Res. 2008 Jun 1;14(11):3582-8.
 
18519792 
Roth JC, Curiel DT, Pereboeva L. (2008) Cell vehicle targeting strategies. Gene Ther. May;15(10):716-29. Epub 2008 Mar 27. Review.  18369326 
Komarova S, Kawakami Y, Stoff-Khalili MA, Curiel DT and Pereboeva L. Mesenchymal Progenitor Cells As Cellular Vehicles for Delivery of Oncolytic Adenoviruses. Mol Cancer Ther. 2006 Mar;5(3):755-66.  16546991 
Tsuruta Y, Pereboeva L, Glasgow JN, Luongo CL, Komarova S, Kawakami Y, Curiel DT. Reovirus sigma1 fiber incorporated into adenovirus serotype 5 enhances infectivity via a CAR-independent pathway. Biochem Biophys Res Commun. 2005 Sep 16;33(1):205-14.
 
16061208 
Pereboeva L, Curiel DT. Cellular vehicles for cancer gene therapy: current status and future potential. BioDrugs. 2004;18(6):361-85. Review.  15571421 
Pereboeva L, Komarova S, Mahasreshti PJ, Curiel DT. Fiber-mosaic adenovirus as a novel approach to design genetically modified adenoviral vectors. Virus Res. 2004 Sep 15;105(1):35-46.   15325079 
Pereboeva L, Komarova S, Mikheeva G, Krasnykh V, Curiel DT. Approaches to utilize mesenchymal progenitor cells as cellular vehicles. Stem Cells. 2003;21(4):389-404.
 
12832693 
Pereboev A, Pereboeva L, Curiel DT. Phage display of adenovirus type 5 fiber knob as a tool for specific ligand selection and validation. J Virol. 2001 Aug;75(15):7107-13.  11435591 
Pereboeva LA, Pereboev AV, Wang LF, Morris GE. Hepatitis C epitopes from phage-displayed cDNA libraries and improved diagnosis with a chimeric antigen. J Med Virol. 2000 Feb;60(2):144-51.   10596013  
Pereboeva L and Roth J. (2007) Mesenchymal stem cells as vehicles for delivering therapeutics and oncolytic viruses. In: Bertolotti R and Ozawa K. (Eds.) Autologous and cancer stem cell gene therapy. Progress in Gene Therapy Vol.3, WSPC, Singapore.   

Keywords
gene therapy, cell therapy