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Faculty Detail    
Campus Address WP P230 Zip 7331
Phone  (20-5) -421
Other websites

Medical School  Federal University of Rio Grande do Sul, Brazil    1983  MD 

Diplomate of The American Board of Pathology (ABP) in combined Anatomic and Clinical Pathology  1997 
Diplomate of The American Board of Pathology in Hematology  1998 
Diplomate of The American Board of Pathology in Blood Banking/Transfusion Medicine  2000 

Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Laboratory Medicine Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
I received my M.D. degree from the Federal University of Rio Grande do Sul in Brazil, followed by residency in Internal Medicine at the same institution. I moved to the United States with my husband in 1986 to become a Research Fellow at the National Institutes of Health in Bethesda, Maryland, for 2 years. We then moved to Boston, where I continued working as a fellow at Harvard Medical School. In 1993, we relocated to Birmingham, Alabama. I completed a residency in Pathology and a fellowship in Hematopathology at UAB and am Board certified in Anatomic and Clinical Pathology, with subspecialties in Hematology and Transfusion Medicine/Blood Banking. I am Professor of Pathology at UAB, serving medical director of Transfusion Services. I spend my time doing patient care, teaching, clinical research and administrative duties. In the clinical arena, I am particularly interested in improving appropriateness of utilization of blood products and laboratory tests. I thoroughly enjoy giving lectures locally and in other institutions on these topics and the role of the clinical pathologist in decreasing diagnostic error. Finally, UAB is a pioneer in Patient Blood Management through a collaboration between the Transfusion Services, clinicians and hospital administration since 2007.

Society Memberships
Organization Name Position Held Org Link
Academy of Clinical Laboratory Physicians and Scientists (ACLPS)  Past-President 
American Society for Apheresis (ASFA)  Past-President 
American Society of Clinical Pathologists (ASCP) 
American Society of Hematology (ASH) 

Research/Clinical Interest
Fat embolism syndrome (FES), thrombotic thrombocytopenic purpura (TTP)
I am interested in various aspects of clinical research in the fields of coagulation and transfusion medicine. Since UAB is a center of reference for apheresis, we receive patients from throughout Alabama and neighboring states to be treated here for thrombotic thrombocytopenic purpura (TTP). In the last several years, I have been involved in several projects about TTP as seen in my list of publications. Other areas of interest in Transfusion Medicine include the effect of storage time on the red blood cells and the repercussion for the patients, as well as transfusion-related acute lung injury (TRALI). In the area of coagulation, I have an interest in hypercoagulability, heparin-induced thrombocytopenia diagnosis, and cost-effective utilization of laboratory assays.

Selected Publications 
Publication PUBMEDID
129. May JE, Sullivan JC, LaVie D, LaVie K, Marques MB. Inside out: Bone marrow necrosis and fat embolism complicating sickle-β+ thalassemia. Am J Med 2016 Jun 10; doi: 10.1016/j.amjmed.2016.05.027.  27296331  
Pathology Consultation on the Diagnosis and Treatment of Thrombotic Microangiopathies (TMAs). Am J Clin Path 2016;145:158-65.  27124904  
Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism. Free Radic Biol Med 2015; 22;143-53.  26475426  
Rh immune globulin dosing in the obesity epidemic era. Arch Path Lab Med 2015;139:1084.  26317451 
Apheresis in developing countries around the world. J Clin Apher 2015;30:238-46.  25346394 
Passiment E, Meisel JL, Fontanesi J, Fritsma G, Aleryani SL, Marques M. Decoding laboratory test names: A major challenge to appropriate patient care. J Gen Inter Med 2013;28:453-8.   23192446 
Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements. Transfusion 2015;55:2967-78.  26202471 
Goyal J, Reddy VB, Marques MB. Acquired von Willebrand’s disease in myelofibrosis and essential Thrombocythemia. Haemophilia 2013;19:e256-7.  23590694 
Apheresis research-more abstracts should be published as full manuscripts to provide more evidence for clinical practice guidelines. J Clin Apher 2015 May 23. doi: 10.1002/jca.21405.  26011563 
Scott J, McCleskey B, Adamski J, and Marques MB. Thrombotic thrombocytopenic purpura does not show seasonal variation in Alabama. Transfusion 2013;53:1864-5.   23927642 
Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage. Free Radic Biol Med 2015;85:207-18  25933588 
Goyal J, Adamski J, Lima JO, Marques MB. Relapses of thrombotic thrombocytopenic purpura after treatment with rituximab. J Clin Apher 2013;28:390-4.  23857472 
Metabolic plasticity in resting and thrombin activated platelets. PLoS One 2015;10:e0123597.  25875958 
Hu X, Patel RP, Weinberg JA, Stapley R, Marques MB, Barnum SR. The level of complement activation fragments is higher in red blood cell units than segments. Transfus Apher Sci 2013;49:692-3.  24189461 
Novak DJ, Bai Y, Cooke RK, Marques MB, Fontaine MJ, Gottschall JL, Carey PM, Scanlan RM, Fiebig EW, Shulman IA, Nelson JM, Flax S, Duncan V, Daniel-Johnson JA, Callum JL, Holcomb JB, Fox EE, Baraniuk S, Tilley BC, Schreiber MA, Inaba K, Rizoli S, Podbielski J, Cotton BA, and Hess JR on behalf of the PROPPR Study Group. Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: the experience of the PROPPR trial centers. Transfusion 2015;55:1331-9.  25823522 
Sarode R, Bandarenko N, Brecher ME, Kiss JE, Marques MB, Szczepiorkowski ZM, Winters JL. Thrombotic thrombocytopenic purpura: 2012 American Society for Apheresis (ASFA) consensus conference on classification, diagnosis, management, and future research. J Clin Apher 2014; 29:148-67.  24136342 
Oliver JC, Griffin RL, Hannon T, Marques MB. The success of our patient blood management program depended on an institution-wide change in transfusion practices. Transfusion 2014;54(10 Pt 2):2617-24.  24410741 
Carlo W, Kirklin JK, Pearce FB, Marques MB, Adamski J, George JF. Single center experience with extracorporeal photopheresis in pediatric heart transplantation. J Heart Lung Transpl 2014; 33:624-8.  24661684 
Vetter TR, Adhami L, Porterfield J, Marques MB. Perceptions about blood transfusion: A survey of surgical patients and their anesthesiologists and surgeons. Anest Analg 2014;118:1301-8.   24842177 
Singh N, Vanlandingham S, Halverson C, Marques MB, Tallaj J, Kirklin J, Adamski J. Therapeutic plasma exchange rapidly improves cardiac allograft function in patients with presumed antibody-mediated rejection. J Clin Apher 2014;29:316-21.   24891048 
Marques MB, Wille KM, Ren Z, Sheth M, McGiffin DC. Successful pulmonary thromboendarterectomy in a patient with sickle cell disease treated with a single pre-operative red cell exchange. Transfusion 2014;54:1901-2.   25041151 
Williams LA, Hunter JM, Marques MB, Vetter TR. Periprocedural management of patients on anticoagulants. N Am Clin Lab Med 2014; 34:595-611.   25168945 
Vetter TR, Short RT, Hawn MT, Marques MB. Perioperative management of the patient with a coronary artery stent. Anesthesiology 2014;121:1093-8.   25211171 
Eichbaum Q, Smid WM, Crookes R, Naim N, Mendrone A Jr, Marques JF Jr, Marques MB. Apheresis in developing countries around the world. J Clin Apher 2014 Oct 27. doi: 10.1002/jca.21368. [Epub ahead of print].   25346394 
Limdi N, Nolin T, Booth S, Centi A, Marques MB, Crowley M, Allon M, Beasley T. Influence of kidney function on risk of supra-therapeutic INR related hemorrhage in warfarin users: A prospective warfarin cohort study. Am J Kidney Dis 2014 Nov 25. pii: S0272-6386(14)01377-8. doi: 10.1053. [Epub ahead of print].  25468385 
Dasararaju R, Marques MB. Adverse effects of transfusion. Cancer Control 2015;22:16-25.  25504275 
Harper V, Oh JW, Stapley R, Marques MB, Wilson L, Barnes S, Sun CW, Townes T, Patel RP. Peroxiredoxin-2 recycling is inhibited during erythrocyte storage. Antioxid Redox Signal 2015 Feb 1;22(4):294-307.   25264713 

Thrombotic thrombocytopenic purpura (TTP), fat embolism syndrome (FES)