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Faculty Detail    
Name BRANDON SCOTT PRUETT
Assistant Professor, Department of Psychiatry and Behavioral Neurobiology
Associate Scientist, Comprehensive Neuroscience Center (CNC)
Associate Scientist, Civitan International Research Center (CIRC)
 
Campus Address CIRC 593A Zip 0021
Phone  205-996-6130
E-mail  bspruett@uabmc.edu
Other websites NCBI Bibliography
GoogleScholar Citations
ResearchGate Profile
LinkedIn Profile
     

Education
Undergraduate  Louisiana Scholars' College at Northwestern State University    2006  B.A. 
Graduate  Louisiana State University Health Sciences Center in Shreveport    2012  Ph.D. 
Medical School  Louisiana State University Health Sciences Center in Shreveport    2014  M.D. 
Residency  Warren Alpert Medical School of Brown University    2018  General Adult Psychiatry 

Certifications
Rhode Island Limited Physician License  2014-2017 
Rhode Island Allopathic Physician License  2017-2018 
Alabama Full Unrestricted MD License  2018-present 
Psychiatry, Diplomat of the American Board of Psychiatry and Neurology  2018-present 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Psychiatry   Psych - Adult Assistant Professor
Center  Civitan International Research Center  Civitan International Research Center Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor

Biographical Sketch 
I earned a dual MD/PhD from Louisiana State University Health Sciences Center in Shreveport, receiving my PhD in 2012 and my MD in 2014. During my graduate studies, I examined how aging influences the molecular regulation of dopamine in the rat basal ganglia in the lab of Michael Salvatore, PhD. This research resulted in two first author publications, as well as six additional publications, and helped instill in me a desire to better understand molecular mechanisms in the brain that are involved in human behavior and how these mechanisms go awry in disease states. In my final years of medical school, I developed a strong interest in Psychiatry and a desire to pursue a research-oriented career in this field and to reorient my research toward understanding the molecular mechanisms underlying Psychiatric illness. To this end, I completed my General Adult Psychiatry Residency Training at the Warren Alpert Medical School of Brown University in 2018. During my residency I was a prominent member of the research track and had the great fortune of being mentored by Eric Morrow, MD, PhD with whom I studied a rare genetic neurodevelopmental and possibly neurodegenerative condition called Christianson syndrome, which is caused by mutations in Na+/H+ Exchanger 6 (NHE6), a protein that helps regulate the pH of endosomes by deacidifying them. I helped characterize neurodegenerative changes in the mouse model of Christianson syndrome and analyzed magnetic resonance images from patients with Christianson syndrome to identify structural brain changes associated with this disease, findings which have led to one published manuscript and another that is currently in preparation. Upon completing my residency training in 2018, I accepted a tenure track position as Assistant Professor in the Department of Psychiatry and Behavioral Neurobiology at the University of Alabama at Birmingham. I currently split my time between clinical work as an Attending Psychiatrist on our Adult Inpatient Teaching Service and academic research in the lab of the Chair of my department, James Meador-Woodruff, MD, a world-renowned expert in molecular disruptions in schizophrenia brain. Here, I am applying the knowledge I gained during my research in residency with Dr. Morrow to investigate how disruptions to intracellular compartmental pH regulation may contribute to schizophrenia pathophysiology.



Research/Clinical Interest
Title
Intracellular compartmental disruptions of pH in Schizophrenia
Description
Our group studies molecular disruptions in the serious mental illness schizophrenia looking primarily in postmortem human brain. My research, in particular, focuses on understanding how schizophrenia may alter the molecular regulation of intracellular compartmental pH and how this, in turn, may underlie deficits in protein modification and trafficking seen in this illness.

Selected Publications 
Publication PUBMEDID
Salvatore MF, McInnis TR, Cantu MA, Apple DM, Pruett BS. Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency. Mol Neurobiol. 2018 Jul 28.  30056575 
Xu M, Ouyang Q, Gong J, Pescosolido MF, Pruett BS, Mishra S, Schmidt M, Jones RN, Gamsiz Uzun ED, Lizarraga SB, Morrow EM. Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-Null Mouse Model of Christianson Syndrome. eNeuro. 2018 Jan 17;4(6). pii: ENEURO.0388-17.2017.  29349289 
Salvatore MF, Terrebonne J, Cantu MA, McInnis TR, Venable K, Kelley P, Kasanga EA, Latimer B, Owens CL, Pruett BS, Yu Y, Luedtke R, Forster MJ, Sumien N, Ingram DK. Dissociation of Striatal Dopamine and Tyrosine Hydroxylase Expression from Aging-Related Motor Decline: Evidence from Calorie Restriction Intervention. J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):11-20.   28637176 
Pruett BS, Salvatore MF. Nigral GFRα1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity. Mol Neurobiol. 2013 Jun;47(3):988-99.  23321789 
Salvatore MF, Pruett BS, Dempsey C, Fields V. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. J Vis Exp. 2012 Aug 10;(66). pii: 4171.  22907542 
Salvatore MF, Pruett BS. Dichotomy of tyrosine hydroxylase and dopamine regulation between somatodendritic and terminal field areas of nigrostriatal and mesoaccumbens pathways. PLoS One. 2012;7(1):e29867.  22242182 
Keller CM, Salvatore MF, Pruett BS, Guerin GF, Goeders NE. Biphasic dopamine regulation in mesoaccumbens pathway in response to non-contingent binge and escalating methamphetamine regimens in the Wistar rat. Psychopharmacology (Berl). 2011 Jun;215(3):513-26.  21523347 
Pruett BS, Salvatore MF. GFR α-1 receptor expression in the aging nigrostriatal and mesoaccumbens pathways. J Neurochem. 2010 Nov;115(3):707-15.  20731758 
Salvatore MF, Pruett BS, Spann SL, Dempsey C. Aging reveals a role for nigral tyrosine hydroxylase ser31 phosphorylation in locomotor activity generation. PLoS One. 2009 Dec 23;4(12):e8466.  20037632 
Pruett BS, Pruett SB. An explanation for the paradoxical induction and suppression of an acute phase response by ethanol. Alcohol. 2006 Jun;39(2):105-10. Epub 2006 Oct 2.  17134663 

Keywords
schizophrenia, pH, Na+-H+ Exchangers (NHEs)