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Faculty Detail    
Name RAKESH PRAVINCHANDRA PATEL
  
Campus Address BMR2 532 Zip 2186
Phone  (205) 975-9225
E-mail  rakeshpatel@uabmc.edu
Other websites
     

Education
Undergraduate  University of Essex    1993  BSc. Hons 
Graduate  University of Essex    1996  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Joint Pathology  Molecular & Cellular Pathology Professor
Secondary  Anesthesiology Chair Office  Anesthesiology Chair Office Associate Professor
Secondary  Environmental Health Sciences  Environmental Health Sciences Professor
Secondary  Surgery - General Surgery  Surgery - Gen Surg Trauma Section Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  Med - Cardiovascular Disease  Ctr Cardiovasc Bio (Org Ret) Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor
Center  Ctr for Exercise Medicine (Org Ret)  Ctr for Exercise Medicine (Org Ret) Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor
Center  Integrative Center for Aging Research  Integrative Center for Aging Research Professor
Center  Nephrology Research & Training Center  Nephrology Research & Training Center Professor
Center  Nutrition Sciences Research  Nutrition Obesity Res Ctr (NORC) Professor
Center  UAB Immunology Institute  UAB Immunology Institute Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr Patel graduated from the University of Essex, UK, where he also obtained his Ph.D in 1996. He then joined the Department of Pathology, University of Alabama at Birmingham (UAB) as a post-doctoral fellow, where he is currently Professor and Vice Chair for Research, and Director of the UAB Center for Free Radical Biology. Dr Patel’s research centers on understanding the mechanisms that regulate acute and chronic inflammation with a goal of using these insights to develop and test therapeutics targeted to prevent or limit inflammatory injury. Current areas of research include i) investigating how heme proteins regulate reactive oxygen and nitrogen species (including nitric oxide and nitrite) to modulate transfusion toxicity, acute lung injury and ischemia reperfusion injury and ii) understanding how post-translational regulation of protein by N-glycans regulate endothelial cell reactivity and monocyte adhesion in the context of atherosclerosis.

Society Memberships
Organization Name Position Held Org Link
American Thoracic Society     
International Society for Free Radical Research     
Society for Free Radical Biology and Medicine     
 



Research/Clinical Interest
Title
Modulation of Inflammation by Reactive Species and N-glycans
Description
We incorporate basic science and translational studies in pursuit of our research interests which are to understand redox related mechanisms regulating inflammation in various pathogenic states and how these are integrated to environmental stresses. We have three primary areas of focus i) understanding the molecular basis of nitric oxide and nitrite interactions with different organs and red blood cells and how these impact upon biological processes associated with blood flow regulation and pulmonary function during hypoxia, inflammation (associated with bronchopulmonary dysplasia, Sepsis, trauma, transfusion, transplantation or in response to inhaled (environmental) irritants), ii) understanding the role and effects of free hemoglobin and heme on acute inflammatory stress in the lung (ALI, ARDS) with a focus on interactions with matrikines, and ii) understanding how post-translational modification of proteins by carbohydrates control endothelial cell function and immune cell trafficking to regulate the inflammatory responses. We employ an integrative approach utilizing biochemical, molecular, cell culture and pre-clinical models to develop and test hypotheses and use the insights gained from studies design and conduct translational / clinical studies to test promising therapeutics.

Selected Publications 
Publication PUBMEDID
Mark A. Duerr, Elisa N.D. Palladino, Celine L. Hartman, James A. Lambert, Jacob D. Franke, Carolyn J. Albert, Sadis Matalon, Rakesh P. Patel, Arne Slungaard, and David A. Ford (2018). Bromofatty aldehyde derived from bromine exposure and myeloperoxidase and eosinophil peroxidase modify glutathione and protein. J. Lipid Res. Apr;59(4):696-705.   PMC5880502 
Rekha Gautam, Joo-Yeun Oh, Marisa B. Marques, Richard A. Dluhy, Rakesh P. Patel (2018) Characterization of Storage induced Red Blood Cell hemolysis using Raman Spectroscopy. Laboratory Medicine 49(4): 298-310   PMC6180846 
Jaideep Honavar, Stephen Doran, Joo Yeon Oh, Chad Steele, Sadis Matalon, Rakesh P. Patel (2014) Nitrite therapy improves post-chlorine gas exposure survival. AJP Lung Cell Mol Physiol 307:L888 PMCID: PMC4254962  PMCID: PMC4254962 
Phosgene inhalation causes hemolysis and acute lung injury.
Aggarwal S, Jilling T, Doran S, Ahmad I, Eagen JE, Gu S, Gillespie M, Albert CJ, Ford D, Oh JY, Patel RP, Matalon S.
Toxicol Lett. 2019 Sep 15;312:204-213 		 PMID: 31047999 
Potential role for age as a modulator of oral nitrate reductase activity
Khandaker Ahtesham Ahmed 1, Kiyoung Kim 2, Karina Ricart 1, William Van Der Pol 3, Xiaoping Qi 4, Marcas M Bamman 5, Christian Behrens 6, Gordon Fisher 7, Michael E Boulton 4, Casey Morrow 5, Pamela V O'Neal 8, Rakesh P Patel 9
Nitric Oxide . 2021 Mar 1;108:1-7. doi: 10.1016/j.niox.2020.12.001. 		 PMID: 33321206 
Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures.
Margaroli C, Benson P, Sharma NS, Madison MC, Robison SW, Arora N, Ton K, Liang Y, Zhang L, Patel RP, Gaggar A.
Cell Rep Med. 2021 Apr 20;2(4):100242. doi: 10.1016/j.xcrm.2021.100242. Epub 2021 Mar 23.
 		 PMID: 33778787 
A mechanism for matrikine regulation in acute inflammatory lung injury.
Robison SW, Li J, Viera L, Blackburn JP, Patel RP, Blalock JE, Gaggar A, Xu X.
JCI Insight. 2021 Apr 8;6(7):e140750. doi: 10.1172/jci.insight.140750.
 		 PMID: 33830084 
Human and rodent red blood cells do not demonstrate xanthine oxidase activity or XO-catalyzed nitrite reduction to NO.
Lewis SE, Rosencrance CB, De Vallance E, Giromini A, Williams XM, Oh JY, Schmidt H, Straub AC, Chantler PD, Patel RP, Kelley EE.
Free Radic Biol Med. 2021 Oct;174:84-88. doi: 10.1016/j.freeradbiomed.2021.07.012. Epub 2021 Jul 15.
 		 PMID: 34273539 
Safety and toxicology assessment of sodium nitrite administered by intramuscular injection.
Miller L, Hébert CD, Grimes SD, Toomey JS, Oh JY, Rose JJ, Patel RP.
Toxicol Appl Pharmacol. 2021 Oct 15;429:115702. doi: 10.1016/j.taap.2021.115702. Epub 2021 Aug 28.
 		 PMID: 34464673 
Supplemental nitrite increases choroidal neovascularization in mice.
Qi X, Ricart K, Ahmed KA, Patel RP*, Boulton ME*.
Nitric Oxide. 2021 Dec 1;117:7-15. doi: 10.1016/j.niox.2021.09.005. Epub 2021 Sep 16.
*Co-Senior Author 		 PMID: 34537345  
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Keywords
vascular, hemoglobin, red cells, Inflammation, isoflavones, Nitric oxide, nitrite, N-glycan, matrikine