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Faculty Detail    
Name YOGESH DWIVEDI
Professor
Elesabeth Ridgely Shook Endowed Chair in Psychiatry
Director, Translational Research, UAB Mood Disorder Program
 
Campus Address SC 711A Zip 0017
Phone  205-975-8459
E-mail  ydwivedi@uab.edu
Other websites
     

Education
Undergraduate  University of Allahabad, India     1982  BS 
Graduate  University of Allahabad, India     1986  MS 
Graduate  Central Drug Research Institute, India (Affiliate of Awadh University, India)    1992  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Psychiatry   Psych - Behavioral Neurobiology Professor
Secondary  Neurobiology  Neurobiology Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor

Biographical Sketch 
Dr. Dwivedi earned his Bachelors and Masters degrees from the University of Allahabad and his Ph.D. From the Central Drug Research Institute, Lucknow, India in biochemistry. He then served as a postdoctoral research fellow at the Illinois State Psychiatric Institute and the University of Illinois, Chicago (UIC), after which he entered the faculty of the Department of Psychiatry at UIC in 1994. Dr. Dwivedi rose through the ranks and became a Professor with tenure in the Departments of Psychiatry and Pharmacology at UIC in 2011. Dr. Dwivedi is internationally recognized as an expert in the molecular biology of mood disorders and suicide. His current research examines the roles of neurotransmitter receptors, cytokines, neurotrophins, cellular signaling, and neural plasticity in depression and suicide risk using gene expression, RNA sequencing, microRNAs, and epigenetic approaches. Dr. Dwivedi joined the department of Psychiatry and Behavioral Neurobiology in 2013.



Research/Clinical Interest
Title
Elucidating molecular mechanisms associated with mood disorders and suicide.
Description
The major objective of my research is to elucidate the molecular and cellular mechanisms associated with mood disorders, stress-related pathology, and suicidal behavior by integrating basic and clinical neuroscience to comprehensively examine the roles of neurotransmitter receptors, cytokines, neurotrophins, cellular signaling, and neural plasticity utilizing gene expression, RNA sequencing, microRNAs, and epigenetic approaches. The model systems that I have been using include human postmortem brain, peripheral blood cells, and animal models of behavioral depression and PTSD, and gene knockout mice.

Selected Publications 
Publication PUBMEDID
Dwivedi Y, Rizavi HS, Conley RR. Pandey GN. ERK-MAP kinase signaling in postmortem brain of suicide subjects: Differential regulation of upstream Raf kinases, Raf-1 and B-Raf. Mol Psychiatry 11, 86-98, 2006.  16172610 
Dwivedi Y, Rizavi HS, Pandey GN. Antidepressants reverse corticosterone-mediated decrease in BDNF expression: Dissociation in regulation of specific exons by antidepressants and corticosterone. Neuroscience 139, 1017-1029, 2006.  16500030 
Dwivedi Y, Mondal A, Rizavi HS, Faludi G, Palkovits M, Sarosi A, Conley RR. Pandey GN. Differential and brain region-specific regulation of Rap-1 and Epac in depressed suicide victims. Arch Gen Psychiatry 63, 639-648, 2006.  16754837 
Pandey GN, Rizavi HS, Dwivedi Y. Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: Effects of treatment and clinical response. J Am Acad Child Adoles Psychiatry. 47: 1077-85, 2008.  18611289 
Dwivedi Y, Rizavi H, Teppen T, Sasaki N, Chen H, Zhang H, Roberts R, Conley R, Pandey G: Aberrant extracellular signal-regulated kinase (ERK) 5 signaling in hippocampus of suicide subjects. Neuropsychopharmacology 32, 2338-50, 2007.  17342168 
Donati RJ, Dwivedi Y, Roberts RC, Conley RR, Pandey GN, Rasenick MM Post-mortem brain tissue of depressed suicides reveals increased Gsα localization in lipid raft domains where it is less likely to activate adenylyl cyclase. J. Neuroscience 19;28:3042-50, 2008.  18354007 
Dwivedi Y, Rizavi H, Teppen T, Zhang H, Mondal A, Roberts R, Conley R, Pandey G: Lower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory subunit isoforms in prefrontal cortex and hippocampus of suicide subjects. Neuropsychopharmacology 33, 2324-40, 2008.  18075493  
Dwivedi Y, Rizavi H, Zhang H, Mondal A, Roberts RC, Conley RR, Pandey GN. Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide. Biol. Psychiatry 65, 319-28, 2009.  18930453 
Dwivedi Y, Rizavi HS, Zhang H, Roberts RC, Conley RR, Pandey GN. Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: role of ERK kinase 1 (MEK1). Int J. Neuropsychopharmacology 12(10):1337-54, 2009.   19835659 
Smalheiser N, Lugli G. Rizavi H, Torcik V, Pandey G, Davis J, Dwivedi Y. MicroRNA expression in rat brain exposed to repeated inescapable shock: differential alterations in learned helplessness vs. non-learned helplessness. Int. J. Neoropsychopharmacol., 14, 1315-25, 2011.  22427989 
Serafini, G, Pompili M, Innamorati, M, Giordano G, Tatarelli, R, Lester D, Girardi P, Dwivedi Y. Glycosides, depression and suicideal behavior: The role of glycoside-linked proteins. Molecules, 16(3):2688-713, 2011.  21441870 
Dwivedi Y. Evidence demonstrating role of microRNAs in the etiopathology of major depression. Journal of Chemical Neuroanatomy 42, 142-56, 2011.  21515361 
Pandey GN, Rizavi HS, Ren X, Fareed J, Hoppensteadt DA, Roberts RC, Conley RR, Dwivedi Y. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatry Res. 46, 57-63, 2012.  21906753 
Smalheiser NR, Lugli G, Rizavi HS, Torvik VI, Turecki G, Dwivedi Y. MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS One 7(3) e33201, 2012.  22427989 
Dwivedi Y. Involvement of brain-derived neurotrophic factor in late-life depression. Am J. Geriatric Psychiatry 21(5):433-49, 2013.  23570887 

Keywords
Mood Disorders, Suicide, Signal Transduction, Gene Regulation, Epigenetics