Appointment Type |
Department |
Division |
Rank |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Assistant Professor |
Primary |
Med - Hematology & Oncology |
Med - Hematology & Oncology |
Assistant Professor |
|
Biochemistry and Structural Biology |
Cancer Biology |
Cell, Molecular, & Developmental Biology |
Cellular and Molecular Biology Program |
Genetics and Genomic Sciences |
Genetics and Genomic Sciences |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Wang BB, Lu R, Wang WC, Jin Y. Inducible and reversible suppression of Npm1 gene expression using stably integrated small interfering RNA vector in mouse embryonic stem cells. Biochemical and biophysical research communications. 2006; 347(4):1129-37. |
16870143 |
Li H, Wang B, Yang A, Lu R, Wang W, Zhou Y, Shi G, Kwon SW, Zhao Y, Jin Y. Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells. Stem cells (Dayton, Ohio). 2009; 27(6):1244-54. |
19489080 |
Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Kwon SW, Zhao Y, Li J, Jin Y. Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(4):1402-7. |
20080709 |
Lu R, Yang A, Jin Y. Dual functions of T-box 3 (Tbx3) in the control of self-renewal and extraembryonic endoderm differentiation in mouse embryonic stem cells. The Journal of biological chemistry. 2011; 286(10):8425-36. |
21189255 |
Yang A, Shi G, Zhou C, Lu R, Li H, Sun L, Jin Y. Nucleolin maintains embryonic stem cell self-renewal by suppression of p53 protein-dependent pathway. The Journal of biological chemistry. 2011; 286(50):43370-82. |
22013067 |
Cai L*, Rothbart SB*, Lu R* (co-first author), Xu B, Chen WY, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J, Wang GG. An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular cell. 2013; 49(3):571-82. |
23273982 |
Lu R, Wang GG. Tudor: a versatile family of histone methylation 'readers'. Trends in biochemical sciences. 2013; 38(11):546-55. |
24035451 |
Yu H, He K, Wang L, Hu J, Gu J, Zhou C, Lu R, Jin Y. Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins. Journal of cell science. 2015; 128(15):2881-90. |
26065429 |
Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin C, Fu JD, Wang GG, Liu J, Qian L. Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming. Cell stem cell. 2016; 18(3):382-95. |
26942853 |
Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen WY, Abdel-Wahab O, Wade PA, Zheng D, Wang GG. Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development. Cancer cell. 2016; 30(1):92-107. |
27344947 |
Lu R, Wang GG. Gene enhancer deregulation and epigenetic vulnerability. Oncoscience. 2016; 3(11-12):299-301. |
28105447 |
Lu R, Wang GG. Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia. Frontiers in oncology. 2017; 7:241. |
29075615 |
Zhang ZM*, Lu R* (co-first author), Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG, Song J. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature. 2018; 554(7692):387-391. |
29414941 |
Xu B, Cai L, Butler JM, Chen D, Lu X, Allison DF, Lu R, Rafii S, Parker JS, Zheng D, Wang GG. The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem cell reports. 2018; 10(3):675-683. |
29456179 |
Cai L, Tsai YH, Wang P, Wang J, Li D, Fan H, Zhao Y, Bareja R, Lu R, Wilson EM, Sboner A, Whang YE, Zheng D, Parker JS, Earp HS, Wang GG. ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. Molecular Cell. 2018; 72(2):341-354.e6. |
30270106 |
Lu R, Wang J, Ren Z, Yin J, Wang Y, Cai L, Wang GG. A Model System for Studying the DNMT3A Hotspot Mutation (DNMT3A R882) Demonstrates a Causal Relationship between Its Dominant-Negative Effect and Leukemogenesis. Cancer Research. 2019; 79(14):3583-3594 |
31164355 |
Pi WC, Wang J, Shimada M, Lin JW, Geng H, Lee YL, Lu R, Li D, Wang GG, Roeder RG, Chen WY. E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia. Blood. 2020 Jul 2;136(1):11-23. |
32276273 |
Zhang H*, Zhang Y*, Zhou X*, Wright S, Hyle J, Zhao L, An J, Zhao X, Shao Y, Xu B, Lee HM, Chen T, Zhou Y, Chen X, Lu R#;, Li C#;. Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen. Elife. 2020 Oct 1;9:e57858. (*equal contribution, #; corresponding author) |
33001025 |
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