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Faculty Detail    
Name CHARLES ROGER WHITE
Professor of Medicine, Division of Cardiovascular Disease		  
Campus Address ZRB 1046 Zip 0007
Phone  (205) 934-1296
E-mail  rogerwhite@uabmc.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Med - Cardiovascular Disease  Med - Cardiovascular Disease Professor Emeritus

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Cell, Molecular, & Developmental Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. White is a Professor of Medicine in the Division of Cardiovascular Disease. He received his doctoral training in the Department of Physiology and Biophysics at the University of Illinois at Urbana-Champaign. Dr. White went on to pursue postdoctoral studies in the Vascular Biology and Hypertension training program situated in UAB’s Cardiology Division. He subsequently joined the faculty in the Division of Cardiovascular Disease in 1993. Dr. White has provided lectures in cardiovascular pharmacology and shock pathophysiology to both graduate and medical students, in addition to mentoring undergraduates, graduates, postdoctoral fellows and clinical fellows. Dr. White has published approximately 75 peer-reviewed manuscripts in top tier journals, such as Science, Circulation Research and Journal of Lipid Research. Dr. White is a Fellow of the American Heart Association Council for High Blood Pressure Research and the American Physiological Society Cardiovascular Section.



Selected Publications 
Publication PUBMEDID
Anantharamaiah GM, Garber D, Goldberg D, Morrel E, Datta G, Palgunachari M, Register T, Appt S, and White CR. Novel fatty acyl apoE mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaques. J. Lipid Research. 59: 2075-2083, 2018.   6210918 
White CR, Giordano S, and Anantharamaiah GM. High-density lipoprotein, mitochondrial dysfunction and cell survival mechanisms. Chemistry and Physics of Lipids. 199: 161-169, 2016.  4972637 
Giordano S, Datta G, Wolkowicz P, Garber DW, Palgunachari M, White CR, and Anantharamaiah GM. The apolipoprotein E mimetic peptide AEM-2 attenuates mitochondrial injury and apoptosis in human THP-1 macrophages. Current Topics in Peptide and Protein Research. 19:15-25, 2018.   6019287 
White CR, and Anantharamaiah GM. Cholesterol reduction and macrophage function: role of paraoxonases. Current Opinion in Lipidology. 28: 397-402, 2017.   5649384 
White CR, Datta G, and Giordano S. High-Density Lipoprotein Regulation of Mitochondrial Function. Adv Exp Med Biol. 982: 407-429, 2017.   5822681 
White CR, Giordano S, and Anantharamaiah GM. High-density lipoprotein, mitochondrial dysfunction and cell survival mechanisms. Chemistry and Physics of Lipids. 199: 161-169, 2016.   4972637 
Anantharamaiah GM, Garber D and White CR. Apolipoprotein mimetic peptides as modulators of lipoprotein function. Protein & Peptide Letters. 23: 1024-1031, 2016.   27586181 
White CR, Datta G, and Giordano S. High-Density Lipoprotein Regulation of Mitochondrial Function. Adv Exp Med Biol. 982: 407-429, 2017.   5822681 
White CR, and Anantharamaiah GM. Cholesterol reduction and macrophage function: role of paraoxonases. Current Opinion in Lipidology. 28: 397-402, 2017.   5649384 
Darley-Usmar VM, McAndrew J, Patel R, Moellering D, Lincoln T, Jo H, Cornwell T, Digerness S, White CR. Nitric oxide, free radicals and cell signaling in cardiovascular disease. Biochemical Society Transactions 25: 925-930, 1997.  9388574 
White CR, Darley-Usmar V, Oparil S. No role for NO in estrogen-mediated vasoprotection? Circulation 96: 2769-2771, 1997.  9386133 
White CR, Moellering D, Kirk M, Barnes S, Darley-Usmar VM. Formation of the NO donors glyceryl mononitrate and mononitrite from the reaction of peroxynitrite with glycerol. Biochemical Journal 328: 517-524, 1997.  9371710 
White CR, Shelton J, Chen SJ, Durand J, Allen L, Darley-Usmar V, Nabors C, Sanders PW, Chen YF, Oparil S. Estrogen restores endothelial cell function in an experimental model of vascular injury. Circulation 96: 1624-1630, 1997.  9315557 
White CR, Darley-Usmar V, McAdams M, Berrington WR, Gore J, Thompson JA, Parks DA, Tarpey MM, Freeman BA. Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits. Proceedings of the National Academy of Sciences (USA) 93: 8745-8749, 1996.  8710942 
Aslan M, Ryan TM, Adler B, Townes TM, Parks DA, Thompson JA, Tousson A, Gladwin MT, Patel RP, Tarpey MM, Batinic-Haberle I, White CR, Freeman BA. Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proceedings of the National Academy of Sciences (USA) 98: 15215-15220, 2001.  11752464 
Baldus S, Eiserich JP, Mani A, Castro L, Figueroa M, Chumley P, Ma W, Tousson A, White CR, Bullard DC, Brennan ML, Lusis AJ, Moore KP, Freeman BA. Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration. Journal of Clinical Investigation 108: 1759-1770, 2001  11748259 
Zhang C, Kelpke S, Ma W, Zhou F, Parks DA, Darley-Usmar V, White CR. Endothelial dysfunction is induced by the proinflammatory oxidant hypochlorous acid. American Journal of Physiology. 281: H1469-H1475, 2001.  11557534 
Zhang C, Reiter C, Eiserich JP, Darley-Usmar VM, Parks DA, Beckman JS, Barnes S, Kirk M, Baldus S, White CR. L-arginine chlorination products inhibit endothelial nitric oxide production. Journal of Biological Chemistry 276: 27159-27165, 2001.  11375389 
Tarpey MM, White CR, Suarez E, Richardson G, Radi R, Freeman BA. Lucigenin enhances superoxide formation in vascular tissue. Coelenterazine as an alternative chemiluminescent probe for the detection and measurement of superoxide in vascular tissue. Circulation Research 84: 1203-1211, 1999.  10347095