Cell, Molecular, & Developmental Biology  http://www.gbs.uab.edu  http://www.uab.edu/graduate  Back to Main

Faculty Detail    
Name ADRIENNE C. LAHTI
Professor and Chair
Director, Comprehensive Neuroscience Center
Co-Director, Alabama Advanced Imaging Consortium		  
Campus Address SC 501 Zip 0017
Phone  (205) 996-6776
E-mail  alahti@uab.edu
Other websites http://labs.uab.edu/alahti/about
     

Education
Medical School  University of Liege (Belgium)      M.D. 

Certifications
Board Certification in Psychiatry and Neurology   


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Psych - Behavioral Neurobiology  Psych - Behavioral Neurobiology Professor
Secondary  Neurobiology  Neurobiology Professor
Secondary  Psychology  Psychology Professor
Center    Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  Comprehensive Neuroscience Center  Comprehensive Neuroscience Center Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor
Center  Ctr for Dev Func Imaging (CDFI) (Org-Ret)  Ctr for Dev Func Imaging (CDFI) (Org-Ret) Professor
Center  Evelyn F. McKnight Brain Institute  Evelyn F. McKnight Brain Institute Professor
Center  Vision Science Research Center (Org-Ret)  Vision Science Research Center (Org-Ret) Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cell, Molecular, & Developmental Biology 
Neuroscience 



Research/Clinical Interest
Title
Neuroimaging
Description
Use of multimodal brain imaging techniques (PET, fMRI, MR Spectroscopy) to study the neuropathology of schizophrenia and bipolar disorder and to evaluate the effects of psychotropic drugs on brain function and biochemistry. Translational work aiming at bridging human brain imaging and postmortem studies.

Selected Publications 
Publication PUBMEDID
Roberts, R.C., Barksdale, K.A., Roche, J.K., Lahti, A.C. Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophrenia. Schizophrenia Research, Epub ahead of print  26210550 
Cropsey, K.L., Clark, C.B., Zhang, X., Hendricks, P.S., Jardin, B.F., Lahti, A.C. Race and Medication Adherence Moderate Cessation Outcomes in Criminal Justice Smokers. American Journal of Preventive Medicine, 49(3): 335-44, 2015  26091924 
Bardeen, J.R., Stevens, E.N., Clark, C.B., Lahti, A.C., Cropsey, K.L. Cognitive risk profiles for anxiety disorders in a high-risk population. Psychiatry Research, 229(1-2): 572-6, 2015  26089016 
Robert, S.M., Buckingham, S.C., Campbell, S.L., Robel, S., Holt, K.T., Ogunrinu-Babarinde, T., Warren, P.P., White, D.M., Reid, M.A., Eschbacher, J.M., Berens, M.E., Lahti, A.C., Nabors, L.B., Sontheimer, H. SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma. Science Translational Medicine, 7(289): 289, 2015  26019222 
Libero, L.E., DeRamus, T.P., Lahti, A.C., Deshpande, G., Kana, R.K. Multimodal neuroimaging based classification of autism spectrum disorder using anatomical, neurochemical, and white matter correlates. Cortex, 66:46-59, 2015  25797658 
Skidmore, F.M., Spetsieris, P.G., Anthony, T., Cutter, G.R., von Deneen, K.M., Liu, Y., White, K.D., Heilman, K.M., Myers, J., Standaert, D.G., Lahti, A.C., Eidelberg, D., Ulug, A.M. A full-brain, bootstrapped analysis of diffusion tensor imaging robustly differentiates Parkinson disease from healthy controls. Neuroinformatics, 13(1): 7-18, 2015  24974315 
Hutcheson, N.L., Sreenivasan, K.R., Deshpande, G., Reid, M.A., Hadley, J., White, D.M., Ver Hoef, L., Lahti, A.C. Effective connectivity during episodic memory retrieval in schizophrenia participants before and after antipsychotic medication. Human Brain Mapping, 36(4): 1442-57, 2014  25504918 
Bolding, M.S., Lahti, A.C., White, D., Moore, C., Gurler, D., Gawne, T.J., Gamlin, P.D. Vergence eye movements in patients with schizophrenia. Vision Research, 102: 64-70, 2014  25088242 
Wheelock, M.D., Reid, M.A., To, H., White, D.M., Cropsey, K.L., Lahti, A.C. Open label smoking cessation with varenicline is associated with decreased glutamate levels and functional changes in anterior cingulate cortex: preliminary findings. Front Pharmacol, 5: 158, 2014  25071576 
Kraguljac, N.V., White, D.M., Hadley, J., Reid, M.A., Lahti, A.C. Hippocampal-parietal dysconnectivity and glutamate abnormalities in unmedicated patients with schizophrenia. Hippocampus, 24(12): 1524-32, 2014  25045047 
Cropsey, K.L., Trent, L.R., Clark, C.B., Stevens, E.N., Lahti, A.C., Hendricks, P.S. How low should you go? Determining the optimal cutoff for exhaled carbon monoxide to confirm smoking abstinence when using cotinine as reference. Nicotine & Tobacco Research, 16(10): 1348-55, 2014  24891552 
Cropsey, K.L., Leventhal, A.M., Stevens, E.N., Trent, L.R., Clark. C.B., Lahti, A.C., Hendricks, P.S. Expectancies for the Effectiveness of Different Tobacco Interventions Account for Racial and Gender Differences in Motivation to Quit and Abstinence Self-Efficacy. Nicotine & Tobacco Research, 2014.  24719492 
Gulsuner, S., Walsh, T., Watts, A.C., Lee, M.K., Thornton, A.M., Casadei, S., Rippey, C., Shahin, H. Consortium on the Genetics of Schizophrenia (COGS); PAARTNERS Study Group, Nimgaonkar VL, Go RC, Savage RM, Swerdlow NR, Gur RE, Braff DL, King MC, McClellan JM. Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network. Cell, 154 (3): 518-29, 2013.   23911319 
Hutcheson, N.L., Clark, D.G., Bolding, M.S., White, D.M., Lahti, A.C. Basal ganglia volume in unmedicated patients with schizophrenia is associated with treatment response to antipsychotic medication. Psychiatry Research: Neuroimaging, 221(10): 6-12, 2014.   24210948 
Hadley, J.A., Nenert, R., Kraguljac, N.V., Bolding, M.S., White, D.M., Skidmore, F.M., Visscher, K.,Lahti, A.C. Ventral tegmental area/midbrain functional connectivity and response to antipsychotic medication in schizophrenia. Neuropsychopharmacology, 39(4): 1020-30, 2014.   24165885 
Kraguljac, N.V., Cutter, G.R., Morgan, C., Lahti, A.C. The problem of Spurious Correlations between Pairs of Brain Metabolite Values Measured in the Same Voxel with MRS – Reply. JAMA Psychiatry, 71(3): 339-40, 2014.   24599245 
Barksdale, K.A., Lahti, A.C., Roberts, R.C. Synaptic protein dysregulation in the postmortem anterior cingulate cortex in schizophrenia: relationship to treatment response. Neuropsychopharmacology, Mar 7, 2014.   24603856 
Weller, R.E., Avsar, K.B., Cox, J.E., Reid, M.A., White, D.M., Lahti, A.C. Delay discounting and task performance consistency in patients with schizophrenia. Psychiatry Research, 1781(13)00745-2, 2013  24388727 
Avsar, K.B., Weller, R.E., Cox, J.E., Reid, M., White, D., Lahti, A.C. An fMRI investigation of delay discounting in patients with schizophrenia. Brain Behavior, 3(4):384-401, 2013.  24381810 
Kraguljac, N.V., White, D.M., Reid, M.A., Lahti, A.C. Increased Hippocampal Glutamate and Volumetric Deficits in Unmedicated Patients With Schizophrenia. JAMA Psychiatry, Oct. 9, 2013.  24108440 
Kraguljac, N.V., Srivastava, A., Lahti, A.C.; Memory deficits in schizophrenia: a selective reveiw of functional magnetic resonance imaging (FMRI) studies; Behavioral Science, 3(3): 330-47, 2013.  25379242 
Reid, M.A., Kraguljac, N.V., Avsar, K.B., White, D.M., den Hollander, J.A., Lahti, A.C. Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia. Schizophr Res. 2013   23706412 
Bolding, M.S., White, D.M., Hadley, J.A., Weiler, M., Holcomb, H.H., Lahti, A.C. Antipsychotic drugs altered functional connectivity between medial frontal cortex, hippocampus, and ventral striatum. Frontiers in Psychiatry, 3: 105, 2012  23230425 
Bolding, M.S., Lahti, A.C., Gawne, T.J., Hopkins, K.B., Gurler, D., Gamlin, P.D. Ocular convergence deficits in schizophrenia. Frontiers in Psychiatry, 3: 86, 2012.  23087652 
Bolding, M., Reid, M., Avsar, K.B., Roberts, R., Gamlin, P., Gawne, T., White, D., den Hollander, J., Lahti, A.C. Magnetic Transfer Contrast Accurately Localizes Substantia Nigra Confirmed by Histology. Biol Psychiatry. 2012 Sep;pii: S0006-3223(12)00697-X. doi: 10.1016/j.biopsych.2012.07.035.  22981657 
Kraguljac, N., Reid, M., White, D.M., den Hollader, J.A., Lowman, D.K., Lahti, A.C. Neurometabolites in schizophrenia and bipolar disorder-a systematic review and meta-analysis. Psychiatry Research: Neuroimaging, 203 (2-3): 111-25, 2012.  22981426 
Hutcheson, N., Reid, M.A., White, D.M., Kraguljac, N.V., Avsar, K.B., Bolding, M.S., Knowlton, R.C., Den Hollander, J.A., Lahti, A.C. Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging. Schizophrenia Research, 140 (1-3): 136-42, 2012.  22831772 
Kraguljac, N., Reid, M., White, D., den Hollander, J.A., Lahti, A.C. Regional Decoupling of N-acetyl-aspartate and Glutamate in schizophrenia. Neuropsychopharmacology. 2012 Jul;doi:10.1038/npp.2012.126.  22805603 
Savage, R.M., Weiner, H.W., Nimgaonkar, V., Devlin, B., Calkins, M.E., Gur, R.E., O'Jile, J., Bradford, L.D., Edwards, N., Kwentus, J., McEvoy, J.P., Nasrallah, H., Santos, A.B., Aduroja, T., Allen, T., Lahti, A.C., Mays, R.S., Montgomer-Barefield, L. Go RCP: Heritability of Functioning in Families with Schizophrenia in Relation to Neurocognition. Schizophrenia Research, 139 (1-3): 105--, 2012  22627125 
Avsar, K.B., Stoeckel, L.E., bolding, M., White, D.M., Tagamets, M., Holcomb, H.H., Lahti, A.C. Aberrant visual circuitry associated with normal spatial match-to-sample accuracy in schizophrenia. Psychiatry: Neuroimaging, 193 (3): 138-43, 2011.  21782395 
Lahti, A.C., Reid, M.A. Is there Evidence for Neurotoxicity in the Prodromal and Early Stages of Schizophrenia? Neuropsychopharmacology, 36 (9): 1779-80, 2011.  21753798 
Somerville, S.M., Lahti, A.C., Conley, R.R., Roberts, R.C. Mitochondria in the Striatum of Subjects with Schizophrenia: relationship to treatment response. Synapse. 2011 Mar;65(3):215-24.  20665724 
Reid, M.A., Stoeckel, L.E., White, D.M., Avsar, K.B., Bolding, M.S., Akella, N.S., Knowlton, R.C., den Hollander, J.A., and Lahti, A.C. Assessments of Function and Biochemistry of the Anterior Cingulate Cortex in Schizophrenia. Biol Psychiatry. 2010 Oct 1;68(7):625-33. Epub 2010 Jun 8.  20570244 
Hong, L.E., Summerfelt, A., Buchanan, B.W., O’Donnell, P., Thaker, G.K., Weiler, M.A., Lahti, A.C. Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamine. Neuropsychopharmacology, 35 (3):632-640, 2010.  19890262 
Lahti AC, Weiler MA, Holcomb HH, Tamminga AC, Cropsey, K: Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia. Neuropsychopharmacology, 34: 2675-2690, 2009.  19675535 
Roberts, RC, Roche JK, Conley RR, Lahti AC. Dopaminergic synapses in the caudate of subjects with schizophrenia: relationship to treatment response. Synapse, 63: 520-30, 2009.  19226604 
Artaloytia, J.F.; Arango, C.; Lahti, A.C.; Sanz, J.; Pascual, A.; Cubero, P.; Prieto, D., Palomo, T. Negative signs and symptoms secondary to antipsychotics: a double-blind randomized trial of a single dose of placebo, haloperidol, and risperidone in healthy volunteers. American Journal of Psychiatry,163: 488-93, 2006.  16513871 
Lahti, A.C., Holcomb, H.H., Weiler, M.A., Medoff , D.R., Tamminga, C.A. Functional effects of antipsychotic drugs: comparing clozapine with haloperidol. Biological Psychiatry, 53(7): pp 601-608, 2003
 		 12679238 
Parwani, A., Weiler, M.A., Blaxton, T.A., Warfel, D., Hardin, M., Lahti, A.C. The effects of a subanesthetic dose of ketamine on verbal memory in normal volunteers. Psychopharmacology, 183: 265-74, 2005.  16220331 
Lahti, A.C., Weiler, M.A., Holcomb, H.H., Tamminga, C.A., Carpenter, W.T., McMahon, R. Correlations between rCBF and symptoms in two independent cohorts of drug free patients with schizophrenia. Neuropsychopharmacology, 31: 221-30, 2006.  16123774 
Holcomb, H.H., Lahti, A.C., Medoff, D.R., Cullen, T, Tamminga, C.A.: Effects of noncompetitive NMDA blockade on regional cerebral blood flow in schizophrenia limbic cortex. Neuropsychopharmacology, 30: 2275-82, 2005.  16034443 
Lahti, A.C., Weiler, M.A., Medoff, D.R., Tamminga, C.A., Holcomb, H.H.: Functional effects of single dose first and second generation antipsychotic administration in subjects with schizophrenia. Psychiatry Research: Neuroimaging, 139; 19-30, 2005  15950442 
LaPorte, D.J., Blaxton, T.A., Michaelidis, T., Robertson, D.U., Weiler, M.A., Tamminga, C.A ., Lahti, A.C. : Subtle effects of ketamine on memory when administered following stimulus presentation. Psychopharmacology, 180: 385-90, 2005.  15719220 
Tamminga, C.A., Lahti, A.C., Medoff, D.R., Gao X., Holcomb, H.H.: Evaluating glutamatergic transmission in schizophrenia. Ann NY Acad Sci, 1003: 113-118, 2003  14684439 
Lahti, A.C., Holcomb, H.H.: Schizophrenia, VIII: Pharmacologic models. Am J Psychiatry, 160(12): 2091, 2003  14638574 
Holcomb, H.H. Parwani, A., McMahon, R.P., Medoff, D.R., Frey, K., Lahti, A.C., Tamminga, C.A.: Parametric study of accuracy and response time in schizophrenia persons making visual or auditory discriminations. Schizophrenia Research, 127: 207-216, 2004
 		 15296820 
Lahti, A.C., Holcomb, H.H., Weiler, M.A., Medoff, D.R., Frey, K.N., Hardin, M., Tamminga, C.A. Clozapine but not haloperidol re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex.Neuropsychopharmacology, 29(1): 171-8, 2004
 		 14520337 
 

Keywords
psychiatry, schizophrenia, research, lahti