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Faculty Detail    
Name BALEED VISHNU VARDHAN REDDY
  
Campus Address WP P230 Zip 7331
Phone  (205) 934-5295
E-mail  vreddy@uabmc.edu
Other websites
     

Education
Medical School  Kakatiya Medical College (Osmania University), Warangal, AP, India    1972  MD 
Residency  M.G.M Hospital, Warangal, AP, India    1973  House Surgeon (Rotating Internship) 
Residency  Atlantic City Medical Center, Atlantic City, New Jersey     1973-1975  Anatomic Pathology 
Residency  West Virginia University Medical Center, Morgantown, West Virginia     1975-1978  Anatomic and Clinical Pathology 

Certifications
American Board of Pathology, Anatomic & Clinical Pathology  1978 
Special Qualification in Hematology (American Board of Pathology)  1986 
Voluntary Recertification AP/CP, American Board of Pathology  2013 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Clinical Pathology  Laboratory Medicine Professor
Secondary  Clin Lab Sci Div (Org Ret)  Clin Lab Sci Div (Org Ret) Associate Professor Clinical
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
EDUCATION: M.D., 1972 - Kakatiya Medical College/Osmania University, Warangal, AP, India POSTDOCTORAL TRAINING: House surgeon - 1973 (Rotating Internship) - M.G.M. Hospital, Warangal, AP, India Resident, Anatomic Pathology, 1973-1975, Atlantic City Medical Center, Atlantic City, NJ Resident, Anatomic and Clinical Pathology, 1975 - 1978, Chief Resident - West Virginia University Medical Center, Morgantown, WV. Military Service: Active Duty, US Army (1978-1992, Colonel, MC) Army Reserves (IMA), USAMRIID, Ft. Detrick, MD (1996-2008) Retired Reserves US Army, Colonel, Medical Corps, 2009-current Academic and Clinical Appointments: Medical Director, Hematology/Bone Marrow Lab, 1978 - 83, William Beaumont Army Medical Center, El Paso, TX Medical Director, Hematology/Bone Marrow Lab, 1983 - 93, Fitzsimmons Army Medical Center, Aurora, CO Associate Professor, 1993-2000;Professor of Pathology, 2000-current. Section Head, Hematology / Co-Section Head, Bone Marrow Lab, 1993 - current, University of Alabama at Birmingham, Birmingham, AL Director, Hematopathology Fellowship Program, 2001 - current, University of Alabama at Birmingham, Birmingham, AL Module Leader, Hematology/Oncology Module, UASOM MS-II BOARD CERTIFICATION: 1978 American Board of Pathology, Anatomic & Clinical Pathology 1986 Special Qualification in Hematology (American Board of Pathology). 2013 Voluntary Re-certification(AP/CP, American Board of Pathology) Biosketch: I have diagnostic and clinical expertise in the area of Hematopathology; including in Flow Cytometry, lymphoma, leukemia, myelodysplastic/myeloproliferative neoplasms, plasma cell neoplasms/myeloma, hemoglobinopathies and Surgical Pathology. My research interests are in bone marrow topography, tissue microarrays (TMA), FISH, immuno-architecture in bone marrow and lymph nodes, automated needle biopsy techniques, muse models of leukemia, (FLIT3-ITD), IRESSA trial in non-small cell lung carcinomas and CD30 expression in mast cells. Other areas I did work on include digital imaging, image analysis, Web-technology and developing techniques for digital image quantification of hemophagocytosis in macrophage activation syndrome (MAS) on the bone marrow biopsies. I have collaborated extensively with UAB Comprehensive Cancer Center Investigators and other outside University Medical Centers on above research areas resulting in several peer reviewed publications. As educator, I developed Hematopathology teaching guidelines and curriculum for UAB Hematopathology fellows/trainees, and collaborated with other national experts in publishing training guidelines for Hematopathology programs. I have similarly developed curriculum / teaching material for the UAB School of Medicine MS-II students. In addition, I oversee UAB Health system Hematology/Bone marrow laboratories, and responsible for overall QA/QC of the section.

Society Memberships
Organization Name Position Held Org Link
Academy of Clinical Laboratory Physicians and Scientists  Member   
American Society of Hematology   Member, 2012  www.hematology.org 
Association for Molecular Pathology  Member, Hematopathology Section  www.amp.org 
CAP Lab   Accreditation Program Lab Inspector   
Eastern Cooperative Oncology Group (ECOG) / NCI investigator   Member   
Lymphoma/Myeloma and Myeloid Leukemia Committee (translational research) Comprehensive Cancer Center, UAB  Committee Member   
National Comprehensive Cancer Network (NCCN)  CML Committee Member, 2010-present  WWW.nccn.org 
Society for Hematopathology  Member, Education Committee   
United States and Canadian Academy of Pathology   Member Hematopathology Committee   www.uscap.org 
 



Research/Clinical Interest
Title
Scientist, Comprehensive Cancer Center, University of Alabam at Birmingham, Birmingham, AL
Description
Diagnostic Hematopathology, Flow Cytometry, and Surgical Pathology with special interest in lymphoma, leukemia, myelodysplastic/myeloproliferative disorders, plasma cell dyscrasia and anemias. Research interests are in bone marrow topography, tissue microarrays (TMA), FISH, immuno-architecture in bone marrow and lymph nodes. Other areas of interest include developing techniques for digital quantification of hemo-phagocytosis in macrophage activation syndrome on the bone marrow biopsy, bone marrow matrix changes in myelodysplastic syndromes, micro-RNA expression on hematopoietic tumors, immuno-profile of mantle cell lymphoma, CD30 expression in hematopoietic tumors, digital imaging, image analysis and Web-technology.

Selected Publications 
Publication PUBMEDID
Kim HG, LeGrand J, Swindle CS, Nick HJ, Oster RA, Chen D, Purohit-Ghelani S, Cotta CV, Ko R, Garland L, Reddy VVB, Hiebert SW, Friedman AD, Klug CA. The assembly competence domain is essential for in(16)-associated acute myeloid leukemia. Leukemia. 2017 (10):2267-2271. Doi:10.1038/Leu.2017.236.Epub 2017 Jul28
 		  
Mesa RA, Jamieson C, Bhatia R, Deininger MW, Fletcher CD, Gerds AT, Gojo I, Gotlib J, Gundabolu K, Hobbs G, McMahon B, Mohan SR, Oh S, Padron E, Papadantonakis N, Pancari P, Podoltsev N, Rampal R, Ranheim E, Reddy VVB, Rein LAM, Scott B, Snyder DS, Stein BL,
Talpaz M, Verstovsek S, Wadleigh M, Wang ES, Bergman MA, Gregory KM, Sundar H. NCCN Guidelines Insights: Myeloproliferative Neoplasms. Ver 2.2018. J Natl Compr Canc Netw. 2017 Oct;15(10):1193-1207.

 		  
Zhou Y, Reilly SD, Gangaraju R, Reddy VVB, Marques MB. An Unusual presentation of Thrombotic Thrombocytopenic Purpura. Am J Med. 2017 Aug;130(8):e323-2326.
 		  
Jones BS, Jerome MS, Miley D, Jackson BE, DeShazo Mr, Reddy VVB, Singh KP, Brown OC, Robert F. Pilot phase II study of metronomic chemotherapy in combination with bevacizumab in patients with advanced non-squamous non-small cell lung cancer. Lung Cancer. 2017
April;106:125-130.
 		  
Pan Z, Hu S, Li M, Zhou Y, Kim Y.S, Reddy, VVB, Sanmann JN, Smith LM, Chen M, Gao Z, Wang HY, Yuan J. ALK-positive large B-cell lymphoma. Am J. Surgical Pathology. 2017;41(1):25-38.
 		  
Gangaraju R, Reddy VVB, Marques MB. Fat embolism Syndrome secondary to Bone marrow Necrosis in patients with Hemoglobinopathies. South Med J. 2016 Sep;109(9):549-53.


 		  
Yamada T, Siric F, Reddy VVB, Neal Kay G. B-cell lymphoma of the pericardium presenting with ventricular tachycardia with a successful catheter ablation. Heart Rhythm Case Rep. 2016 June 11;2(5):384-387.
 		  
Yin Y, Zu J, Li M, Reddy VVB, Zhou Q, Liu H, Chu P. Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z. Oct2 and Bob1 are sensitive and specific markers in lineage determination of B-cell lymphomas with no expression of conventional B-cell markers. Histopathology. 2016 June 20.doi.19.1111/his. 13017. [Epub ahead of print].
 		  
Pallera A, Altman JK, Berman E, Abboud CN, Bhatnagar B, Curtin P, DeAngelo DJ, Gotlib J, Hagelstrom RT, Hobbs G, Jagasia M, Kantarjian HM, Kropf P, Metheny L, Moore JO, Ontiveros E, Purev E, Quiery A, Reddy VVB, Rose MG, Shah NP, Smith BD, Snyder DS, Sweet KL, Tibes R, Yang DT, Gregory K, Sundar H, Deininger M, Radich JP.NCCN Guidelines Insights: Chronic Myeloid Leukemia. Ver. 2017. J. Natl Compr Can Netw.
2016 Dec’14(12):1505-1512.
 		  
VanValkenburg ME, Pruit GI, Brill IK, Costa L, Estsham M, Jestement IT, Innis-Shelton RD, Salzman D, Reddy ES, Godby KN, Mikhail FM, Carroll AJ, Reddy VVB, Sanderson RD, Sanders PW, Brown EE. Family history of hematologic malignancies and risk of multiple myeloma: Differences by race and clinical features. Cancer Causes Control. 2016 Jan: 27(1):81-91.
 		  
Xu J, Wu X, Reddy VVB. T-cell/Histiocyte-Rich large B-cell lymphoma of the Thymus: A Diagnostic Pitfall. Case Rep Hematol. 2016;2016:2942594, DOI: 1555/2016. Epub Jan 2016
 		  
Ma Y, Reddy VVB, Reilly S. A fatal cases of systemic lupus erythematosus complicated by macrophage activation syndrome, portal vein thrombosis and acute colitis. Int J Rheum Dis. 2014 Dec4. Doi:10. 1111/1756-185X.12511. [Epub ahead of print].    
O'Brien S, Radich JP, Abboud CN, Akhtari M, Altman JK, Berman E, Curtin P, DeAngelo DJ, Deininger M, Devine S, Fathi AT, Gotlib J, Jagasia M, Kropf P, Moore JO, Pallera A, Reddy VVB, Shah NP, Smith BD, Snyder DS, Wetzler M, Gregory K, Sundar H. Chronic Myelogenous Leukemia. Version 1.2015. J Natl Compr Cance Netw. 2014;12(11):1590-610.    
Dai Q, Reddy VVB, Choi JK, Faye-Peterson OM. Trisomy 21-associated transient abnormal myelopoiesis involving the maternal space of the placenta: a case report and literature review. Pedatr Dev Pathol. 2014 Sep-Oct; 17(5):366-73.   
Peker D, Parekh V. Paluri R, Deal t, Borate U, Di Stasi A, Harada S, Arroyo EA, Reddy VVB. Clinicopathologic and molecular features of myeloid sarcoma as initial presentation of therapy related myeloid neoplasms: A single institution experience. Int J Hematol 2014; 100(5): 457-63.    
Marques MB, Singh N, Reddy VV. Out with the bad and in with the good; red cell exchange, white cell reduction, and platelet reduction. J Clin Apher 2014 May 14. doi: 10.1002/jca.21332. [Epub ahead of print]   
Marques MB, Singh N, Reddy VV. Out with the bad and in with the good; red cell exchange, white cell reduction, and platelet reduction. J Clin Apher 2014 May 14. doi: 10.1002/jca.21332. [Epub ahead of print]   
Goyal J, reddy VVB, Marques MB. Acquired von Willebrand’s disease in myelofibrosis and essential thrombocythemia. Haemophilia 2013 Jul;19(4):e256-7   
O'Brien S, Radich JP, Abboud CN, Akhtari M, Altman JK, Berman E, DeAngelo DJ, Deininger M, Devine S, Fathi AT, Gotlib J, Jagasia M, Kropf P, Moore JO, Pallera A, Pinilla-Ibarz J, Reddy VVB, Shah NP, Smith BD, Snyder DS, Wetzler M, Gregory K, Sundar H. Chronic Myelogenous Leukemia, Version 1.2014. J Natl Comr Canc Netw. 2013 Nov;11(11):1327-40.   
Experts in Chronic Myeloid Leukemia (119 Collaborators). The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts. Blood 2013 May;121(22):4439-42.   
Flowers CR, Shenoy PJ, Borate U, Bumpers K, Douglas-H t, King N, Brawley OW, Lipscomb J, Lechowicz MJ, Sinha R, Grover RS, Bernal-M L, Kowalski J, Donnellan W, The A, Reddy VVB, Jaye DL, Foran J. Examining racial differences in diffuse large B-cell lymphoma presentation and survival. Leuk Lymphoma 2013;54(2):268-76.    
Pan ZG, Zhang QY, Lu ZB, Qinto T, Rozenvald IB, Liu LT, Wilson D, Reddy VVB, Huang Q, Wang HY, Ren YS. Extracavitary KSHV-associated large G-cell lymphoma. Am J Surg Path 2012;36(8):1129-40.    
Nunez AL, Jhala NC, Carroll AJ, Mikhail FM, Reddy VVB, Xian RR, Jhala DN. Endoscopic and endobronchial ultrasound-guided fine needle aspiration of deep-seated lymphadenopathy; Analysis of 1338 cases. CytoJournal 2012;9:14;1-10   
Kumar N, Yadav S, Reddy VVB, Robert F. Leukemia cutis. Lancet. 2012 Jun 14. [Epub ahead of print].   
Adamski J, Hanna CA, Reddy VVB, Litovsky SH, Evans CA, Marques MB. Multiorgan failure and bone marrow necrosis in three adults with sickle cell-beta+ thalassemia. Am. J. Hematol. 2012. DOI:10.1002/ajh_23117   
O’Brien S, Abboud CN, Akhtari M, Altman J, Berman E, DeAngelo DJ, Devine S, Fathi AT, Gotlib J, Jagasia M, Moore JO, Pinilla-Ibarz J, Radich JP, Reddy VVB, Shah NP, Shami PJ, Smith BD, Syyder DS. Wezler M. Yunus F. Chronic myelogenous leukemia. Clinical practice guidelines in oncology. J Natl Compr Canc Netw (JNCCN). 2012 Jan1;10(1)64-110.    
Nunez AL, GP Siegal, Reddy VVB, Wei S. CD138 ( Syndecan-1) expression in bone-forming tumors. Am J Clin Pathol. 2012;127:423-428.    
Rossman J, Reddy VVB, Cantor A, Miley D, Robert F. Phase II study of dose-intense chemotherapy with sequential topoisomerase-targeting regimens with irinotecan /oxaliplatin followed by etoposide / carboplatin in chemotherapy naïve patients with extensive small cell lung cancer. Lung Cancer. 2011 May;72;(2):219-23.    
Nick HJ, Kim HG, Chang CW, Harris KW, ReddyVVB, Klug CA. Distinct classes of c-kit activating mutations differ in their ability to promote RUNX1-ETO-associated acute myeloid leukemia. Blood. 2011 Sep 21. [Epub ahead of print)   
Wang CW, Manne U, Reddy VVB, Oelschlager DK, Katkooni VR, Grizzle WE, Kapoor R. Development of combination of tapered fiber-optic biosensor dip-probe for quantitative estimation of interleukin-6 in serum samples. J. Biomedical Optics 2010. 15(6):51-57.    
Rossman J, Reddy VVB, Cantor A, Miley D, Robert F. Phase II study of dose-intense chemotherapy with sequential topoisomerase-targeting regimens with irinotecan /oxaliplatin followed by etoposide / carboplatin in chemotherapy naïve patients with extensive small cell lung cancer. Lung Cancer. 2010 Oct 7 [Epub ahead of print]   
Lima j, Reddy VVB, Marques MB. Systemic neutrophilic aggregates in transfusion-related acute lung injury. Transfusion. 2010:50(7):1427-8.   
Khalifeh I, Hughey L, Huang C, ReddyVVB, Sellheyer K. Solitary plaque on the scalp as primary manifestation of Hodgkin’s lymphoma: A case report and review of the literature. J. Cutan Pathol. 2009 Oct;36 Suppl 1:80   
Balmer NN, Hughey L, Busam KJ, Reddy VVB, Andea AA. Primary cutaneous peripheral T-cell lymphoma with aberrant c expression of CD20: Case report with review of the literature. Am J. Dermatopathol. 2009:31(2):187-92   
Yang Z, Chaffin CH, Easley PL, Thigpen B, Reddy VVB. Prevalence of elevated hemoglobin A2 measured by CAPILLARYS system. AM J Clin Pathol. 2009:131(1):42-48   
Cherry T, Steciuk M, Reddy VVB, Marques M. Transfusion related acute lung injury. Past, present and future. AM J Clin Pathol. 2008:129:287-297.    
Pan G, Chen EY, Feng G, Reddy VVB, Jhala N, McDonald JM. Reciprocal co-expression of Fas and Fas ligand in human cholangiocarcinoma. Int J Oncol. 2007:31(4):21-30.    
Kruspe RC, Ashraf KK, Foran JM, Solzman DE, Reddy VVB, Vaughan WP. Successful Treatment of T-cell Prolymphocytic Leukemia with Full-intensity Conditioning followed by matched unrelated donor Allogeneic Stem cell Transplantation.. Clin Adv in Hem & Onc. 2007:5(11):882-883.   
Bi LL, Pan G, Atkinson TP, Zheng L, Dale JK, Makris C, Reddy VVB, McDonald JM, Siegel RM, Puck JM, Lenardo MJ. Dominant Inhibition of Fas Ligand-Mediated Apoptosis due to a Heterozygous Mutation Associated with Autoimmune Lymphoproliferative Syndrome (ALPS) Type Ib. BMC Medical genetics. 2007:8:41 (BMC open access article http://www.biomedcentral.com/1471-2350/8/41).   
Perkins SL, Reddy VVB, Reichard KK, Thompsen MA., Dunphy CH . Recommended Curriculum for Teaching Hematopathology to Subspecialty Hematopathology fellows. AM J Clin Pathol. 2007:127:962-976.   
Nicholaus J Hilliard, Irfan Warraich, Rachael Kruspe, Belinda Hyche, James Foran, Reddy VVB. Idiopathic Eosinophilic associated CMML-2 with over expression of the ETV6 gene. Lab Medicine. 2007:38 (2);100-102.   
Drabik-Clary K, Reddy VVB, Benjamin WH, Boctor FN. Severe hemolytic disease of the newborn in group B African-American infant delivered by a group O mother. Ann Clin & Lab Science. 2006: 36(2): 205-207.   
Popat U, Frost A, Liu E, Guan Y, Durette A, Reddy VVB, Prchal JT. High levels of circulating CD34 cells, dacryocyte, clonal hematopoiesis, and JAK-2 mutation differentiate myelofibrosis with myeloid metaplasia from secondary myelofibrosis associated with pulmonary hypertension. Blood. 2006: 107:3486-88.   
Meara R, Reddy VVB, Arnoletti JP, Jhala D, Varadarajulu s, Jhala N. Diagnosis of hairy cell leukemia by endoscopic ultrasound guided fine needle aspiration: A case report and review of recent literature. Cytojournal. 2006: 23;3 (1). Online version.    
Reddy, VVB. Selected case studies in hematopathology: Application of current ancillary techniques in diagnosis. Adv Exp Med Biol. 2005;563:112-124.   
Sate Hamza. Digital image acquisition using a consumer-type digital camera in the anatomic pathology setting. Advances in Anatomic Pathology.2004: 11(2): 94-100   
Chen VK, Reddy VVB, Eloubeidi MA. Recurrent mantle cell lymphoma after allogeneic bone marrow transplantation presenting as isolated rectal mass. Dig. Dis Sci. 2003:48(5);1024-6.   
Audeh YM, Gruszecki AC, Cherrington A, Reddy VVB. Hairy cell leukemia with concurrent cryptococcus infection. Am J Hematology. 2003:72(2);223-4   
Gregg XT. Reddy VVB. Prchal JT. Copper deficiency masquerading as myelodysplastic syndrome. Blood 2002:100(4):1493-5.   
Q. Sun, R. Burton, Reddy, VVB, K. Lucas. Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma. Br J Hematology. 2002:118, 799-808.   
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Keywords
Hematopathology, Flow Cytometry, Leukemia, Lymphoma, Bone Marrow Topography, Telepathology, Tissue microarrays (TMA), Anemia, Myelodysplastic Syndromes, Lung Tumor, IRISSA