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Faculty Detail    
Name JIANMING TANG
  
Campus Address RPHB 624 Zip 0022
Phone  (205) 934-5191
E-mail  jtang@uabmc.edu
Other websites https://www.researchgate.net/profile/James_Tang3?ev=prf_info
     

Education
Undergraduate  Beijing Agricultural University, Beijing China    1986  B.Agr.Sci./DVM 
Graduate  The University of Queensland, Brisbane, Australia    1993  PhD 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Med - Infectious Diseases  Med - Infectious Diseases Professor Emeritus

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Genetics, Genomics and Bioinformatics 
Immunology 
Integrative Genetics Graduate Program 

Biographical Sketch 
Jianming ‘James’ Tang (b. 1965) grew up in Hunan Province, China. He studied veterinary medicine at Beijing (China) Agricultural University (1981-1986) before pursuing a PhD degree at The University of Queensland in Brisbane, Australia (1988-1993). After post-doctoral training at the Marine Biological Laboratory (Woods Hole, MA) and at UAB Division of Geographic Medicine, he was appointed as assistant professor in 1996 and promoted to associate professor and full professor in 2004 and 2012, respectively. As documented in over 100 peer-reviewed articles in two dozen scientific journals, Dr. Tang's research has evolved from parasite immunology and molecular entomology to immunogenetics and pharmacogenetics. His current work focuses on genetic and epigenetic contributions to infection and immunity in human populations. Two ongoing projects are funded by NIH (NIAID and NIA).

Society Memberships
Organization Name Position Held Org Link
American Society for Microbiology (ASM)  Member  http://www.asm.org/ 
American Society of Histocompatibility and Immunogenetics (ASHI)  Member  http://www.ashi-hla.org/ 
 



Research/Clinical Interest
Title
Genetic and Epigenetic Correlates of Infection and Immunity
Description
1) Immunogenetics: population genetics; molecular phylogenetics; genotype-phenotype relationships; genetic scoring algorithms 2) Epigenetics: CpG methylation profile; methylation and cytokine gene expression; micoRNA profile 3) Public health: aging and immunologic health in persons living with HIV-1 infection

Selected Publications 
Publication PUBMEDID
54. Erdmann N, Prentice HA, Bansal A, Wiener HW, Burkholder G, Shrestha S and Tang J*. Herpes zoster in persons living with HIV-1 infection: viremia and immunological defects are strong risk factors in the era of combination antiretroviral therapy. Front Pub Health 2018; 6: 70. doi: 10.3389/fpubh.2018.00070. PMC5857573 (ePub 03/12/2018).  29594092 
53. Wiener HW, Shrestha S, Lu H, Karita E, Kilembe W, Allen S, Hunter E, Goepfert PA and Tang J*. Immunogenetic factors in early immune control of human immunodeficiency virus type 1 (HIV-1) infection: Evaluation of HLA class I amino acid variants in two African populations. Hum Immunol 2018; 79: 166-71 (ePub 12/28/2017).   29289742 
52. Prentice HA, Lu H, Price MA, Sanders EJ, Anzala O, Karita E, Kamali A, Lakhi S, Allen S, Goepfert PA, Hunter E, and Gilmour J and Tang J for the International AIDS Vaccine Initiative African HIV Research Network. Dynamics and correlates of CD8 T-cell counts in primary human immunodeficiency virus type 1 infection. J Virol 2016; 90(22): 10423-30.   27630231 
51. Mónaco DC, Dilernia D, Fiore-Gartland A, Yu T, Prince J, Dennis C, Qin K, Schaeffer M, Claiborne D, Kilembe W, Tang J, Price MA, Farmer P, Gilmour J, Bansal A, Allen S, Goepfert P and Hunter E. Balance between transmitted HLA pre-adapted and non-associated polymorphisms is a major determinant of HIV-1 disease progression. J Exp Med 2016; 213(10): 2049-63. PMC5030801 (available 2017-03-19).   27551154 
50. Landais E, Huang X, Price MA, Rida W, Simek M, Havenare-Daughton C, Wickramasinghe L, Ramos A, Bian CB, Allen S, Karita E, Kilembe W, Lakhi S, Inambao M, Kamali A, Sanders EJ, Anzala O, Edward V, Bekker L-G, Tang J, Gilmour J, Wrin T, Crotty S, Godzick A and Poignard P. Broadly neutralizing-antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort. PLoS Pathog 2016; 12(1): e1005369. PMC4713061.  26766578 
49. Erdmann N, Du V, Carlson J, Schaefer M, Jureka A, Sterrett S, Yue L, Dilernia D, Lakhi S, Tang J, Sidney J, Gilmour J, Allen S, Hunter E, Heath S, Bansal A and Goepfert PA. HLA class-II associated HIV-1 polymorphisms predict escape from CD4+ T cell responses. PLoS Pathog 2015; 11(8): e1005111. PMC4547780.  26302050 
48. Tang J, Li X, Price MA, Sanders EJ, Anzala O, Karita E, Kamali A, Lakhi S, Fast P, Allen S, Hunter E, Kaslow RA, and Gilmour J for the IAVI Africa HIV Prevention Partnership. CD4:CD8 lymphocyte ratio as a measure of immunologic health in HIV-1 infection: findings from an African cohort with prospective data. Front Microbiol 2015; 6:670. PMC4486831.   26191056 
47. Claiborne DT, Prince J, Scully E, Macharia G, Micci L, Lawson B, Kopycinski J, Deymier M, Vanderford T, Nganou-Makamdop K, Ende Z, Tang J, Yu T, Lakhi S, Kilembe W, Silvestri G, Douek D, Goepfert P, Price MA, Allen S, Paiardini M, Altfeld M, Gilmour J and Hunter E. Replicative fitness of transmitted HIV-1 drives immune activation, proviral load in memory CD4+ T cells, and disease progression. PNAS; 2015; 112(12): E1480-9. PMC4378387.  25730868 
46. Li X, Zhang K, Pajewski NM, Brill I, Prentice HA, Shrestha S, Kilembe W, Karita E, Allen S, Hunter E, Kaslow RA and Tang J. Immunogenetic influences on acquisition of HIV-1 infection: consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2). Genes Immun 2015; 16(3): 213-20. PMC4409473.  25633979 
45. Yue L, Pfafferott KJ, Baalwa J, Conrod K, Dong CC, Chui C, Rong R, Claiborne DT, Prince JL, Tang J, Ribeiro R, Cormier E, Hahn BH, Perelson AS, Shaw GM, Karita E, Gilmour J, Goepfert P, Derdeyn CA, Allen SA, Borrow P, and Hunter E. Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients. PLoS Pathog 2015; 11(1): e1004565. PMC4287535.  25569444 
44. Li X, Price MA, He D, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Amornkul PN, Allen S, Hunter E, Kaslow RA, Gilmour J and Tang J*, for the IAVI Africa HIV Prevention Partnership. Host genetics and viral load in primary HIV-1 infection: Evidence of gene by sex interactions. Hum Genet 2014; 133(9): 1187-97. PMC4127002.   24969460 
43. Prentice HA, Pajewski NM, He D, Zhang K, Brown EE, Kilembe W, Allen S, Hunter E, Kaslow RA and Tang J*. Host genetics and immune control of HIV-1 infection: Fine mapping for the extended human MHC region in an African cohort. Genes Immun 2014; 15(5): 275-81. PMCID pending (NIHMS580846).   24784026 
42. Carlson JM, Schaefer M, Monaco D, Batorsky R, Claiborne DT, Prince J, Deymier M, Ende ZS, Klatt N, DeZeil C, Lin T-H, Peng J, Shapiro R, Frater J, Thumbi N, Tang J, Goepfert P, Gilmour J, Price MA, Kilembe W, Heckerman D, Goulder PJR, Allen TM, Allen S and Hunter E. Selection bias at the heterosexual HIV-1 transmission bottleneck. Science 2014; 345(6193): 1254031.  25013080 
41. Prentice HA, Price M, Porter TR, Cormier E, Mugavero MJ, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Amornkul PN, Allen S, Hunter E, Kaslow RA, Gilmour J and Tang J, for the IAVI African HIV Research Network. Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates. Virology 2014; 449(2):254-62. PMCID pending. NIHMS544103.  24418560 
40. Porter TR, Li X, Stephensen CB, Mulligan K, Rutledge B, Flynn PM, Lujan-Zilbermann J, Hazra R, Wilson CM, Havens P and Tang J. Genetic associations with 25-hydroxyvitamin D deficiency in HIV-1-infected youth: fine-mapping for GC/DBP gene that encodes the vitamin D-binding protein. Front Genet 2013; 4:234. PMC3827582.  24294218 
39. Merino A, Sabbaj S, Easlick J, Goepfert PA, Kaslow RA and Tang J. Dimorphic HLA-B signal peptides differentially influence HLA-E- and natural killer cell-mediated cytotoxicity against HIV-1-infected target cells. Clin Exp Immunol 2013; 174(3): 414-23. PMC3826307.  23952339 
38. Prentice HA, Porter TR, Price M, Cormier E, He D, Farmer P, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Amornkul PN, Allen S, Hunter E, Kaslow RA, Gilmour J and Tang J, for the IAVI African HIV Research Network. HLA-B*57 versus HLA-B*81 in HIV-1 infection: Slow and steady wins the race? J Virol 2013; 87(7): 4043-51. PMC3624227.  23365442 
37. Yue L, Prentice HA, Farmer P, Song W, He D, Lakhi S, Goepfert PA, Gilmour J, Allen S, Tang J, Hunter E and Kaslow RA. Cumulative impact of host and viral factors on HIV-1 viral load control during early infection. J Virol 2013; 87(2): 708-15. PMC3554094.  23115285 
36. Prince, JL, Claiborne DT, Carlson JM, Schaefer M, Yu T, Lahki S, Prentice HA, Yue L, Vishwanathan SA, Kilembe W, Goepfert P, Price MA, Gilmour J, Mulenga J, Farmer P, Derdeyn CA, Tang J, Heckerman D, Kaslow RA, Allen SA, Hunter E. Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis. PLoS Pathog 2012; 8(11): e1003041. PMC3510241.  23209412 
35. Pajewski NM, Shrestha S, Quinn CP, Parker SD, Wiener H, Aissani B, McKinney BA, Poland GA, Edberg JC, Kimberly RP, Tang J and Kaslow RA. A genome-wide association study of host genetic determinants of the antibody response to anthrax vaccine adsorbed. Vaccine 2012; 30(320: 4778-84.PMC3387748.  22658931 
34.Merino A, Song W, He D, Mulenga J, Allen S, Hunter E, Tang J and Kaslow RA. HLA-B signal peptide polymorphism independently influences the rate of HIV-1 acquisition but not viral load. J Infect Dis 2012; 202(12): 1797-805. PMC3571229.  22492862 
33. Song W, He D, Brill I, Malhotra R, Mulenga J, Allen S, Hunter E, Tang J and Kaslow RA. Disparate associations of HLA class I markers with HIV-1 acquisition and control of viremia in an African population. PLoS ONE 2011; 6(8): e23469. PMC3157381.  21858133 
32. Tang J, Cormier E, Gilmour J, Price M, Prentice H, Song W, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Amornkul PN, Allen S, Hunter E and Kaslow RA, for the IAVI African HIV Research Network. Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct stages of primary HIV-1 infection in sub-Saharan Africans with several viral subtypes. J Virol 2011; 85(17): 8894-902. PMC3165830.  21715491 
31. Song W, Li Y, Wilson CM and Tang J. Identification of three immunologic correlates for HIV type 1 pathogenesis in youth. AIDS Res Human Retroviruses 2011; 27: 639-46.  20969482 
30. Merino A, Malhotra R, Morton M, Mulenga J, Allen S, Hunter E, Tang J and Kaslow RA. Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples. J Infect Dis 2011; 203: 487-95. PMC3071217.  21216870 
29. Shrestha S, Wiener H, Assani B, Song W, Shendre D, Wilson CM, Kaslow RA and Tang J. Interleukin-10 (IL-10) pathway: Genetic variants and outcomes of HIV-1 infection in African American adolescents. PLoS ONE 2010; 5(10): e13384. PMC2954785. doi:10.1371/journal.pone.0013384.   20976276 
28. Lazaryan A, Song W, Lobashevsky E, Tang J, Shrestha S, Zhang K, Gardner LI, McNicholl JM, Wilson CM, Klein RS, Rompalo A, Mayer K, Sobel J, Kaslow, RA. Human leukocyte antigen class I supertypes and HIV-1 control in African Americans. J Virol 2010; 84: 2610-7. PMC2820922.  20032191 
27. Tang J, Malhotra R, Song W, Brill I, Hu L, Farmer PK, Mulenga J, Allen S, Hunter E and Kaslow RA. Human leukocyte antigens and HIV type 1 viral load during early and chronic infection: Predominance of evolving relationships. PLoS ONE 2010, 5(3): e9629. PMC2835758.   20224785 
26. Song W, Ruder A, Hu L, Li Y, Ni R, Shao W, Kaslow RA, Butler MA, and Tang J. Genetic epidemiology of glioblastoma multiforme: Confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs. PLoS ONE 2009; 4(9): e7157. PMC2742900.   19774073 
25. Li Y, Ni R, Song W, Shao W, Shrestha S, Ahmad S, Cunningham CK, Flynn PM, Kapogiannis B, Wilson CM, and Tang J. Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth. Hum Genet 2009; 126: 685-96. DOI 10.1007/s00439-009-0720-z. PMC2771141.  19597844 
24. Shrestha S, Aissani B, Song W, Wilson CM, Kaslow RA and Tang J. Host genetics and HIV-1 viral set-point in African Americans. AIDS 2009; 23: 673-7.   19276793 
23. Crawford H, Lumm W, Leslie A, Schaeler M, Boreas D, Prado JG, Tang J, Farmer P, Ndung'u T, Lakhi S, Gillmour J, Goepfert P, Walker B, Kaslow R, Mulenga J, Allen S, Goulder PJR, Hunter E. Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703 positive individuals and their transmission recipients. J Exp Med 2009; 206: 909-21. PMC2715113.   19307327 
22. Kawashima Y, Pfafferott K, Duda A, Matthews P, Addo M, Gatanaga H, Fujiwara M, Hachiya A, Koizumi H, Kuse N, Oka S, Brumme Z, Brumme C, Allen T, Brander C, Kaslow R, Tang J, Hunter E, Allen S, Mulenga J, Branch S, Roach T, John M, Mallal S, Heckerman D, Frater J, Prendergast A, Crawford H, Leslie A, Prado J, Pybus OG, Klenerman P, Ndung’u T, Phillips R, Harrigan PR, Walker BD, Takiguchi M, Goulder P. Adaptation of HIV-1 to human leukocyte antigen class I. Nature 2009; 458: 641-5.  19242411 
21. Tang J, Shao W, Yoo YJ, Brill I, Mulenga J, Allen S, Hunter E and Kaslow RA. Human leukocyte antigen class I genotypes in relation to heterosexual HIV type 1 transmission within discordant couples. J Immunol 2008; 181: 2626-35. PMC2570252.  18684953 
20. Tang J, Tang S, Rivers CA, Dorak MT, Penman-Aguilar A, Aldrovandi G, Allen S, Karita E, Musonda R, and Kaslow RA. Distinct and evolving HLA class I profiles in native Africans with high prevalence of HIV/AIDS. In Hansen J. (ed.), Immunobiology of the Human MHC: Proceedings of the 13th International Histocompatibility Workshop and Congress (May 18-22, 2002). Seattle: IHWG Press. 2006; Vl. II, pp. 402-7.  24969460 
19. Shao W, Tang J, Song W, Wang C, Li Y, Wilson CM, and Kaslow RA. CCL3L1 and CCL4L1: Variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. Genes Immun 2007; 8: 224-31.  17330138 
18. Lazaryan A, Lobashevsky E, Mulenga J, Karita E, Allen S, Tang J, and Kaslow RA. Human leukocyte antigen B58 supertype and human immunodeficiency virus type 1 infection in native Africans. J Virol 2006; 80: 6056-60. PMC1472610.  16731944 
17. Song W, Wilson CM, Allen S, Wang C, Li Y, Kaslow RA, and Tang J. Interleukin 18 and human immunodeficiency virus type 1 infection in adolescents and adults. Clin Exp Immunol 2006; 144: 117-24. PMC1809636.  16542373 
15. Tang J, Shao W, Dorak MT, Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M, Kaslow RA, and Cobbs CS. Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme. Cancer Epidemiol Biomarkers Prev 2005; 14:2040-4.  16103458 
16. Wang C, Tang J, Geisler WM, Crowley-Nowick PA, Wilson CM, and Kaslow RA. Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents. J Infect Dis 2005; 191: 1084-1092.  15747244 
14. Geisler WM, Tang J, Wang C, Wilson CM, and Kaslow RA. Epidemiological and genetic correlates of incident Chlamydia trachomatis infection in North American adolescents. J Infect Dis 2004; 190: 1723-9.   15499525 
13. Dorak MT, Tang J, Penman-Aguilar A, Westfall AO, Zulu I, Lobashevsky ES, Kancheya NG, Schaen MM, Allen S, and Kaslow RA. Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples. Lancet 2004; 363: 2137-2139.  15220037 
11. Tang, J, Penman-Aguilar A, Lobashevsky E, Allen S, Kaslow RA, and Zambia-UAB HIV Research Project. HLA-DRB1 and -DQB1 alleles and haplotypes in Zambians and their associations with heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). J Infect Dis 2004; 189: 1696-704.  15116308 
12. Wang C, Song W, Lobashevsky E, Wilson CM, Douglas S, Mytilineos J, Schoenbaum EE, Tang J, and Kaslow RA. Cytokine and chemokine gene polymorpshisms among ethnically diverse North Americans with human immunodeficiency virus type 1 (HIV-1) infection. J Acq Immune Defic Syndr 2004; 35: 446-454.  15021309 
10. Tang J, Wilson CM, Meleth S, Myracle A, Lobashevsky E, Mulligan MJ, Douglas SD, Korber B, Vermund SH, and Kaslow RA. Host genetic profiles predict virologic and immunologic control of human immunodeficiency virus type 1 infection in adolescents. AIDS 2002; 16: 2275-2284.   12441799 
9. Tang J, Tang S, Lobashevsky E, Myracle AD, Fideli U, Aldrovandi G, Allen S, Musonda R, and Kaslow RA. Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1. J Virol 2002; 76: 8276-84.  12134033 
8. Tang J, Shelton B, Makhatadze NJ, Zhang YT, Schaen M, Louie L, Goedert JJ, Margolick JB, Mellors J, and Kaslow RA. Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression. J Virol 2002; 76: 662-72.  11752157 
7. Kaslow RA, Rivers CR, Tang J, Goepfert P, Bender TJ, El Habib R, Weinhold K, and Mulligan MJ. Polymorphisms in HLA genes associated with both favorable prognosis of human immunodeficiency virus type 1 (HIV-1) infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines. J Virol 2001;75:8681-9.  11507213 
6. Yee LJ, Tang J, Gibson AW, Kimberly R, van Leeuwen DJ and Kaslow RA. Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection. Hepatology 2001; 33: 708-12.  11230752 
5. Tang J., Freedman DO, Allen S, Karita E, Musonda R, Braga C, Margolick J, Kaslow RA: TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies. Hum Immunol 2001; 62: 256-268.   11250043 
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Keywords
Immunogenetics, Infectious Disease, Pharmacogenetics, Public Health