Appointment Type |
Department |
Division |
Rank |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Professor |
Secondary |
Cell, Developmntl, & Integrative Biology |
Cell, Developmntl, & Integrative Biology |
Professor |
Center |
Comprehensive Cancer Center |
Comprehensive Cancer Center |
Professor |
Center |
Comprehensive Cardiovascular Ctr |
Comprehensive Cardiovascular Ctr |
Professor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Professor |
Center |
Comprehensive Neuroscience Center |
Comprehensive Neuroscience Center |
Professor |
Center |
Med - Cardiovascular Disease |
Ctr Cardiovasc Bio (Org Ret) |
Professor |
Center |
Ctr for Clinical & Translational Sci |
Ctr for Clinical & Translational Sci |
Professor |
Center |
Ctr for Free Radical Bio |
Ctr for Free Radical Bio |
Professor |
Center |
Integrative Center for Aging Research |
Integrative Center for Aging Research |
Professor |
Center |
Nephrology Research & Training Center |
Nephrology Research & Training Center |
Professor |
Center |
Nutrition Sciences Research |
Nutrition Obesity Res Ctr (NORC) |
Professor |
|
Cellular and Molecular Biology Program |
Integrative Biomedical Sciences |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Chatham JC, Young ME, Zhang J. Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications. Current Opinion in Pharmacology 57: 1-12, 2021 https://doi.org/10.1016/j.coph.2020.08.005 |
32937226 |
Brahma MK, Pepin ME, Ha C-M, Sun Z, Chatham JC, Habegger KM, Able ED, Paterson AJ, Young ME, Wende AR. Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization. JAHA 2020; 9:e013039 https://doi.org/10.1161/JAHA.119.013039 |
32750298 |
Chatham JC, Zhang J, Wende AR. Role of O-linked N-acetylglucosamine (O-GlcNAc) protein modification in cellular (patho)physiology. Physiological Reviews https://doi.org/10.1152/physrev.00043.2019 |
32730113 |
Stewart LT, Abiraman K, Chatham JC, McMahon LL. Increased O-GlcNAcylation rapidly decreases GABAAR currents in hippocampus but depresses neuronal output. Scientific Reports 10, Article number: 7494 (2020) https://doi.org/10.1038/s41598-020-63188-0 |
32366857 |
Blasio MJ, Huynh N, Deo M, Dubrana LE, Walsh J, Willis A, Prakoso D, Kiriazis H, Donner, DG, Chatham JC, Ritchie RH. Defining the progression of diabetic cardiomyopathy in a mouse model of type 1 diabetes Frontiers in Physiology. 2020 Feb 20;11:124. doi: 10.3389/fphys.2020.0012 |
32153425 |
Bouchard B, Zhu WZ, Chatham JC, Des Rosiers C, Olson A. Glucose Flux through the Hexosamine Biosynthesis Pathway (HBP): First Characterization in an Ex Vivo Mouse Heart. J Biol Chem. 2020 doi: 10.1074/jbc.RA119.010565 PMID:1915250 |
31915250 |
Acute increases in O-GlcNAc indirectly impair mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover.Wright JN, Benavides GA, Johnson MS, Wani W, Ouyang X, Zou L, Collins HE, Zhang J, Darley-Usmar V, Chatham JC. Am J Physiol Cell Physiol. 2019 Jun 1;316(6):C862-C875. |
30865517 |
Wright JN, Benavides GA, Johnson MS, Wani W, Ouyang X, Zou L, Collins HE, Zhang J, Darley-Usmar V, Chatham JC. Acute increases in O-GlcNAc indirectly impairs mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover. Am J Physiol Cell Physiol 316: C862-C875, 2019. |
30865517 |
Temporal partitioning of adaptive responses of the murine heart to fasting. Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado BA, Peliciari-Garcia RA, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME. Life Sci. 2018 Mar 15;197:30-39. |
29410090 |
Temporal partitioning of adaptive responses of the murine heart to fasting. Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado BA, Peliciari-Garcia RA, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME. Life Sci. 2018 Mar 15;197:30-39. |
29410090 |
Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus. Stewart LT, Khan AU, Wang K, Pizarro D, Pati S, Buckingham SC, Olsen ML, Chatham JC, McMahon LL. J Neurosci. 2017 Aug 23;37(34):8207-8215.
|
28760863 |
Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME. J Mol Cell Cardiol. 2017 Sep;110:80-95. |
28736261 |
O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease. Wani WY, Ouyang X, Benavides GA, Redmann M, Cofield SS, Shacka JJ, Chatham JC, Darley-Usmar V, Zhang J. Mol Brain. 2017 Jul 19;10(1):32. |
28724388 |
O-GlcNAcylation and cardiovascular disease. Wright JN, Collins HE, Wende AR, Chatham JC. Biochem Soc Trans. 2017 Apr 15;45(2):545-553. |
28408494 |
O-GlcNAcylation and neurodegeneration. Wani WY, Chatham JC, Darley-Usmar V, McMahon LL, Zhang J. Brain Res Bull. 2017 Jul;133:80-87. doi: 10.1016/j.brainresbull.2016.08.002. Epub 2016 Aug 4. |
27497832 |
TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling. Chen J, Young ME, Chatham JC, Crossman DK, Dell'Italia LJ, Shalev A. Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H64-75. doi: 10.1152/ajpheart.00151.2016. Epub 2016 May 3. |
27199118 |
Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice. Peliciari-Garcia RA, Goel M, Aristorenas JA, Shah K, He L, Yang Q, Shalev A, Bailey SM, Prabhu SD, Chatham JC, Gamble KL, Young ME. Biochim Biophys Acta. 2016 Oct;1861(10):1579-95 |
26721420 |
Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice.= Peliciari-Garcia RA, Goel M, Aristorenas JA, Shah K, He L, Yang Q, Shalev A, Bailey SM, Prabhu SD, Chatham JC, Gamble KL, Young ME. Biochim Biophys Acta. 2016 Oct;1861(10):1579-95. doi: 10.1016/j.bbalip.2015.12.012. Epub 2015 Dec 22. |
26721420 |
Protein O-GlcNAcylation and cardiovascular (patho)physiology. Marsh SA, Collins HE, Chatham JC. J Biol Chem. 2014 Dec 12;289(50):34449-56 |
25336635 |
Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function. Collins HE, He L, Zou L, Qu J, Zhou L, Litovsky SH, Yang Q, Young ME, Marchase RB, Chatham JC. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1231-9. doi: 10.1152/ajpheart.00075.2014. Epub 2014 Feb 28. |
24585777 |
Activation of AKT by O-linked N-acetylglucosamine induces vascular calcification in diabetes mellitus. Heath JM, Sun Y, Yuan K, Bradley WE, Litovsky S, Dell'Italia LJ, Chatham JC, Wu H, Chen Y. Circ Res. 2014 Mar 28;114(7):1094-102. doi: 10.1161/CIRCRESAHA.114.302968. Epub 2014 Feb 13. |
24526702 |
O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. Taylor EW, Wang K, Nelson AR, Bredemann TM, Fraser KB, Clinton SM, Puckett R, Marchase RB, Chatham JC, McMahon LL. J Neurosci. 2014 Jan 1;34(1):10-21 |
24381264 |
O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. Taylor EW, Wang K, Nelson AR, Bredemann TM, Fraser KB, Clinton SM, Puckett R, Marchase RB, Chatham JC, McMahon LL. J Neurosci. 2014 Jan 1;34(1):10-21. doi: 10.1523/JNEUROSCI.4761-12.2014. |
24381264 |
Collins HE, Zhu-Mauldin X, Marchase RB, Chatham JC. STIM1/Orai1 mediated SOCE: current perspectives and potential roles in cardiac function and pathology. Am J Physiol Heart Circ Physiol. 2013 Jun 21. [Epub ahead of print] |
23792674 |
Lauzier B, Vaillant F, Merlen C, Gélinas R, Bouchard B, Rivard ME, Labarthe F, Dolinsky VW, Dyck JR, Allen BG, Chatham JC, Des Rosiers C. Metabolic effects of glutamine on the heart: anaplerosis versus the hexosamine biosynthetic pathway. J Mol Cell Cardiol. 2013 Feb;55:92-100. |
23201305 |
Zhu-Mauldin X, Marsh SA, Zou L, Marchase RB, Chatham JC. Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes. J Biol Chem. 2012 Nov 9;287(46):39094-106. |
22992728 |
McLarty JL, Marsh SA, Chatham JC. Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart. Life Sci. 2013 Mar 28;92(11):621-7. |
22985933 |
Chatham JC, Young ME. Metabolic remodeling in the hypertrophic heart: fuel for thought. Circ Res. 2012 Aug 31;111(6):666-8. |
22935530 |
Zou L, Zhu-Mauldin X, Marchase RB, Paterson AJ, Liu J, Yang Q, Chatham JC. Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent. J Biol Chem. 2012 Oct 5;287(41):34419-31. |
22908225 |
Hilgers RH, Xing D, Gong K, Chen YF, Chatham JC, Oparil S. Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction. Am J Physiol Heart Circ Physiol. 2012 Sep 1;303(5):H513-22. |
22777418 |
Chatham JC, Young ME. Regulation of myocardial metabolism by the cardiomyocyte circadian clock. J Mol Cell Cardiol. 2013 Feb;55:139-46. |
22766272 |
Marsh SA, Powell PC, Dell'italia LJ, Chatham JC. Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart. Life Sci. 2013 Mar 28;92(11):648-56. |
22728715 |
Medford HM, Chatham JC, Marsh SA. Chronic ingestion of a Western diet increases O-linked-β-N-acetylglucosamine (O-GlcNAc) protein modification in the rat heart. Life Sci. 2012 Jun 14;90(23-24):883-8. |
22575823 |
Chatham JC, Marchase RB. Protein O-GlcNAcylation: A critical regulator of the cellular response to stress. Curr Signal Transduct Ther. 2010 Jan;5(1):49-59. |
22308107 |
Xing D, Gong K, Feng W, Nozell SE, Chen YF, Chatham JC, Oparil S. O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells. PLoS One. 2011;6(8):e24021. |
21904602 |
Darley-Usmar VM, Ball LE, Chatham JC. Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function. J Mol Cell Cardiol. 2012 Mar;52(3):538-49. |
21878340 |
Dranka BP, Benavides GA, Diers AR, Giordano S, Zelickson BR, Reily C, Zou L, Chatham JC, Hill BG, Zhang J, Landar A, Darley-Usmar VM. Assessing bioenergetic function in response to oxidative stress by metabolic profiling. Free Radic Biol Med. 2011 Nov 1;51(9):1621-35. |
21872656 |
Laczy B, Fülöp N, Onay-Besikci A, Des Rosiers C, Chatham JC.Acute regulation of cardiac metabolism by the hexosamine biosynthesis pathway and protein O-GlcNAcylation. PLoS One. 2011 Apr 11;6(4):e18417. |
21494549 |
Des Rosiers C, Labarthe F, Lloyd SG, Chatham JC. Cardiac anaplerosis in health and disease: food for thought. Cardiovasc Res. 2011 May 1;90(2):210-9. |
21398307 |
Marsh SA, Chatham JC. The paradoxical world of protein O-GlcNAcylation: a novel effector of cardiovascular (dys)function. Cardiovasc Res. 2011 Feb 15;89(3):487-8. |
21177335 |
Laczy B, Marsh SA, Brocks CA, Wittmann I, Chatham JC. Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner. Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1715-27. |
20833964 |
Marsh SA, Dell'Italia LJ, Chatham JC. Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice. Amino Acids. 2011 Mar;40(3):819-28. |
20676904 |
Teo CF, Ingale S, Wolfert MA, Elsayed GA, Nöt LG, Chatham JC, Wells L, Boons GJ. Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. Nat Chem Biol. 2010 May;6(5):338-43. |
20305658 |
Nöt LG, Brocks CA, Vámhidy L, Marchase RB, Chatham JC. Increased O-linked beta-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats. Crit Care Med. 2010 Feb;38(2):562-71. |
20016375 |
Hill BG, Dranka BP, Zou L, Chatham JC, Darley-Usmar VM. Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. Biochem J. 2009 Oct 23;424(1):99-107. |
19740075 |
Chatham JC, Marchase RB. The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses. Biochim Biophys Acta. 2010 Feb;1800(2):57-66. |
19607882 |
Degrell P, Cseh J, Mohás M, Molnár GA, Pajor L, Chatham JC, Fülöp N, Wittmann I. Evidence of O-linked N-acetylglucosamine in diabetic nephropathy. Life Sci. 2009 Mar 27;84(13-14):389-93. |
19302818 |
Glickson JD, Forder JR, Chatham JC. Imaging of cardiotoxicity. Mol Imaging. 2008 May-Jun;7(3):115-7. |
19123981 |
Zou L, Yang S, Champattanachai V, Hu S, Chaudry IH, Marchase RB, Chatham JC. Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling. Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H515-23. |
19098112 |
Marsh SA, Dell'italia LJ, Chatham JC. Interaction of diet and diabetes on cardiovascular function in rats. Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H282-92. |
19036853 |
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