Graduate |
Fudan University, Shanghai, China |
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2008 |
Ph.D |
Fellowship |
University of Wisconsin-Madison, Madison, WI |
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2010 |
Postdoctoral Fellow |
Fellowship |
University of Alabama at Birmingham, Birmingham, AL |
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2014 |
Postdoctoral Fellow |
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Appointment Type |
Department |
Division |
Rank |
Primary |
Med - Endocrinology, Diabetes & Metabolism |
Med - Endocrinology, Diabetes & Metabolism |
Instructor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Instructor |
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Publication |
PUBMEDID |
https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/56166057/?sort=date&direction=descending |
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1. Xu G, Thielen LA, Chen J, Grayson TB, Grimes T, Bridges SL Jr, Tse HM, Smith B, Patel R, Li P, Evans-Molina C, Ovalle F, Shalev A. Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss. Am J Physiol Endocrinol Metab. 2019 Aug 13. doi:10.1152/ajpendo.00122.2019. [Epub ahead of print] PMID: 31408375 2. Ovalle F, Grimes T, Xu G, Patel AJ, Grayson TB, Thielen LA, Li P, Shalev A. Verapamil and beta cell function in adults with recent-onset type 1 diabetes. Nat Med. 2018 Aug;24(8):1108-1112. PubMed PMID: 29988125; PubMed Central PMCID: PMC6092963. 3. Jo S, Chen J, Xu G, Grayson TB, Thielen LA, Shalev A. miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function. Diabetes. 2018 Feb;67(2):256-264. PubMed PMID:29101219; PubMed Central PMCID: PMC5780066. 4. Jing G, Chen J, Xu G and Shalev A. Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop. Mol Metab. 2016. Dec. 5 (12), 1208-1215. 5. Xu G*, Chen J, Truman G, Jing G and Shalev A*. MiRNA-204 targets PERK and regulates unfolded protein response signaling and beta cell apoptosis. Mol Endocrinol. 2016. 30 (8), 917-924. (*Corresponding author) 6. Hong K, Xu G, Truman G, Shalev A. Cytokines regulate beta cell TXNIP via distinct mechanisms and pathways. J Biol Chem. In press. 7. Filios SR, Xu G, Chen J, Hong K, Jing G, Shalev A. MiR-200 is induced by thioredoxin-interacting protein and regulates ZEB1 signaling and beta cell apoptosis. J Biol Chem. 2014 Dec 26;289(52):36275-83.. 8. Chen J, Jing G, Xu G and Shalev A. TXNIP stimulates its own expression via a positive feedback loop and ChREBP. Mol Endocrinol. 2014 May;28(5):674-80. 9. Jing G, Westwell-Roper C, Chen J, Xu G, Verchere B and Shalev A. Thioredoxin-interacting protein promotes islets amyloid polypeptide expression through miR-124A and FOXA2. J Biol Chem. 2014 Apr 25;289(17):11807-15. 10. Xu G, Chen J, Jing G, Shalev, A. Thioredoxin-interacting protein regulates insulin transcription through microRNA-204. Nat Med. 2013 Sep;19(9):1141-6. 11. Kibbe C, Chen J, Xu G, Jing G, Shalev A. FOXO1 competes with ChREBP and inhibits TXNIP transcription in pancreatic beta cells. J Biol Chem. 2013 Jun 26. 2013 Aug 9;288(32):23194-202. 12. Cha-Molstad H*, Xu G*, Chen J, Jing G, Young ME, Chatham JC, Shalev A. Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes. Mol Pharmacol. 2012 Sep;82(3):541-9. (*Contributed equally to this work) 13. Xu G, Chen J, Jing G, Shalev A. Preventing beta cell loss and diabetes with calcium channel blockers. Diabetes. 2012 Apr;61(4):848-56. 14. Xu G, Pan Y, Wang B, Huang L, Tian L, Xue J, Chen J, Jia W. TTRAP is a novel PML nuclear bodies-associated protein. Biochem Biophys Res Commun. 2008 Oct 24;375(3):395-8. 15. Xu G, Ren J, Ding N, Ai H, Guo Y, Chen C, Huang L. Genetic analysis of the KIT and MC1R genes in Chinese indigenous pigs with belt-like coat color phenotypes. Anim Genet. 2006 Oct;37(5):518-9. |
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