Undergraduate |
Bharathidhasan University, Trichy, India |
|
1992 |
B.Sc. |
Graduate |
University of Madras, Chennai, India |
|
1994 |
M.Sc. |
Graduate |
University of Madras, Chennai, India |
|
1996 |
M.Phil. |
Graduate |
University of Madras, Chennai, India |
|
2001 |
Ph.D. |
|
Appointment Type |
Department |
Division |
Rank |
Center |
Comprehensive Cardiovascular Ctr |
Comprehensive Cardiovascular Ctr |
Associate Professor |
Center |
Comprehensive Diabetes Center |
Comprehensive Diabetes Center |
Associate Professor |
Center |
Ctr for Exercise Medicine (Org Ret) |
Ctr for Exercise Medicine (Org Ret) |
Associate Professor |
Secondary |
Dept of Biomedical Engineering |
Dept of Biomedical Engineering |
Assistant Professor |
Primary |
Joint Pathology |
Molecular & Cellular Pathology |
Associate Professor |
|
Cellular and Molecular Biology Program |
Medical Scientist Training Program |
Molecular and Cellular Pathology Program |
Pathobiology and Molecular Medicine |
|
Publication |
PUBMEDID |
Sunny S, Challa AK, Qiao A, Jyothidasan A, Krishnamurthy P, Ramamurthy MT, Crossman DK, Pogwizd S, Cinghu S, Rajasekaran NS. Transcriptional Regulation of Structural and Functional Adaptations in a Developing Adulthood Myocardium. Cardiol Cardiovasc Med. 2021;5(5):454-470. doi: 10.26502/fccm.92920215. Epub 2021 Sep 7. PMID: 34497977; PMCID: PMC8423094. |
34497977 |
Henderson J, Dubey PK, Patil M, Singh S, Dubey S, Namakkal Soorappan R, et al. microRNA-377 Signaling Modulates Anticancer Drug-Induced Cardiotoxicity in Mice. Frontiers in Cardiovascular Medicine. 2021;8. |
34485421 |
Quiles JM, Pepin ME, Sunny S, Shelar SB, Challa AK, Dalley B, Hoidal JR, Pogwizd SM, Wende AR, Rajasekaran NS. Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress. Sci Rep. 2021 Jun 7;11(1):11977. doi: 10.1038/s41598-021-90583-y. PMID: 34099738; PMCID: PMC8184797. |
34099738 |
Byrne NJ, Rajasekaran NS, Abel ED, Bugger H. Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy. Free Radic Biol Med. 2021 Jun;169:317-342. doi: 10.1016/j.freeradbiomed.2021.03.046. Epub 2021 Apr 25. PMID: 33910093; PMCID: PMC8285002. |
33910093 |
Ravichandran G, Lakshmanan DK, Murugesan S, Elangovan A, Rajasekaran NS, Thilagar S. Attenuation of protein glycation by functional polyphenolics of dragon fruit (Hylocereus polyrhizus); an in vitro and in silico evaluation. Food Res Int. 2021 Feb;140:110081. doi: 10.1016/j.foodres.2020.110081. Epub 2020 Dec 29. PMID: 33648300. |
33648300 |
Klionsky DJ,...,Rajasekaran NS,...,Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751; PMCID: PMC7996087. |
33634751 |
Kain V, Ingle KA, Rajasekaran NS, Halade GV. Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice. Theranostics. 2021 Jan 1;11(6):2742-2754. doi: 10.7150/thno.51183. PMID: 33456570; PMCID: PMC7806484. |
33456570 |
Narasimhan, K.K.S., Devarajan, A., Karan, G., Sundaram, S., Wang, Q., van Groen, T., Del Monte, F. and Rajasekaran, N.S., 2020. Reductive stress promotes protein aggregation and impairs neurogenesis. Redox biology, 37, p.101739. |
33242767 |
Murugesan, S., Saravanakumar, L., Powell, M.F., Kannappan, R. and Berkowitz, D.E., 2020. Role of exosomal microRNA signatures: An emerging factor in preeclampsia-mediated cardiovascular disease. Placenta. |
33171429 |
Murugesan S, Saravanakumar L, Powell MF, Rajasekaran NS, Kannappan R, Berkowitz DE. Role of exosomal microRNA signatures: An emerging factor in preeclampsia-mediated cardiovascular disease. Placenta. 2021 Jan 1;103:226-231. doi: 10.1016/j.placenta.2020.10.033. Epub 2020 Oct 28. PMID: 33171429; PMCID: PMC8278543. |
33171429 |
Rajasekaran, N.S., 2020. Reductive Stress: Neglected Science. Antioxidants & redox signaling. |
32375496 |
Rajasekaran, N.S., Shelar, S.B., Jones, D.P. and Hoidal, J.R., 2020. Reductive stress impairs myogenic differentiation. Redox biology, 34, p.101492. |
32361680 |
Shanmugam, G., Wang, D., Gounder, S.S., Fernandes, J., Litovsky, S.H., Whitehead, K., Radhakrishnan, R.K., Franklin, S., Hoidal, J.R., Kensler, T.W. and Dell'Italia, L., 2020. Reductive stress causes pathological cardiac remodeling and diastolic dysfunction. Antioxidants & redox signaling, 32(18), pp.1293-1312. |
32064894 |
Miller, J.M., Mardhekar, N.M., Pretorius, D., Krishnamurthy, P., Rajasekaran, N.S., Zhang, J. and Kannappan, R., 2020. DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes. American Journal of Physiology-Heart and Circulatory Physiology, 318(4), pp.H801-H815. |
32057252 |
Pecha, P.P., Almishaal, A.A., Mathur, P.D., Hillas, E., Johnson, T., Price, M.S., Haller, T., Yang, J., Rajasekaran, N.S., Firpo, M.A. and Park, A.H., 2020. Role of Free Radical Formation in Murine Cytomegalovirus–Induced Hearing Loss. Otolaryngology–Head and Neck Surgery, 162(5), pp.709-717. |
32041493 |
Kim, S., Song, J., Ernst, P., Latimer, M.N., Ha, C.M., Goh, K.Y., Ma, W., Rajasekaran, N.S., Zhang, J., Liu, X. and Prabhu, S.D., 2020. MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure. American Journal of Physiology-Heart and Circulatory Physiology, 318(3), pp.H682-H695. |
32004065 |
Kannappan, R., Turner, J.F., Miller, J.M., Fan, C., Rushdi, A.G., Rajasekaran, N.S. and Zhang, J., 2019. Functionally Competent DNA Damage-Free Induced Pluripotent Stem Cell–Derived Cardiomyocytes for Myocardial Repair. Circulation, 140(6), pp.520-522. |
31381423 |
Shanmugam, G., Challa, A.K., Devarajan, A., Athmanathan, B., Litovsky, S.H., Krishnamurthy, P., Davidson, C.J. and Rajasekaran, N.S., 2019. Exercise mediated Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling. Frontiers in cardiovascular medicine, 6, p.68. |
31245386 |
Shanmugam, G., Challa, A.K., Litovsky, S.H., Devarajan, A., Wang, D., Jones, D.P., Darley-Usmar, V.M. and Rajasekaran, N.S., 2019. Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice. Redox biology, 27, p.101212. |
31155513 |
Kuster, D.W., Lynch IV, T.L., Barefield, D.Y., Sivaguru, M., Kuffel, G., Zilliox, M.J., Lee, K.H., Craig, R., Namakkal-Soorappan, R. and Sadayappan, S., 2019. Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy. Cardiovascular research, 115(14), pp.1986-1997. |
31050699 |
Goh, K.Y., He, L., Song, J., Jinno, M., Rogers, A.J., Sethu, P., Halade, G.V., Rajasekaran, N.S., Liu, X., Prabhu, S.D. and Darley-Usmar, V., 2019. Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice. Redox biology, 21, p.101100. |
30641298 |
Berry, J.L., Zhu, W., Tang, Y.L., Krishnamurthy, P., Ge, Y., Cooke, J.P., Chen, Y., Garry, D.J., Yang, H.T., Rajasekaran, N.S. and Koch, W.J., 2019. Convergences of life sciences and engineering in understanding and treating heart failure. Circulation research, 124(1), pp.161-169. |
30605412 |
Haglund, T.A., Rajasekaran, N.S., Smood, B., Giridharan, G.A., Hoopes, C.W., Holman, W.L., Mauchley, D.C., Prabhu, S.D., Pamboukian, S.V., Tallaj, J.A. and Rajapreyar, I.N., 2019. Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture model. The Journal of Heart and Lung Transplantation, 38(4), pp.456-465. |
30503074 |
Devarajan, A., Rajasekaran, N.S., Valburg, C., Ganapathy, E., Bindra, S. and Freije, W.A., 2019. Maternal perinatal calorie restriction temporally regulates the hepatic autophagy and redox status in male rat. Free Radical Biology and Medicine, 130, pp.592-600. |
30248445 |
Rachel A. Brewer, Helen E. Collins, Ryan D. Berry, Manoja K. Brahma, Brian A. Tirado, Rodrigo A. Peliciari-Garcia, Haley L. Stanley, Adam R. Wende, Heinrich Taegtmeyer, Rajasekaran NS, Victor Darley-Usmar, Jianhua Zhang, Stuart J. Frank, John C. Chatham, Martin E. Young. Temporal partitioning of adaptive responses of the murine heart to fasting. Life Sciences 197 (2018) 30–39. |
29410090 |
Bolus DJ, Shanmugam G, Narasimhan M, Rajasekaran NS. 2017. Recurrent heat shock impairs the proliferation and differentiation of C2C12 myoblasts. Cell Stress Chaperones. doi: 10.1007/s12192-017-0851-4. |
29063376 |
Bharat D, Cavalcanti RRM, Petersen C, Begaye N, Cutler BR, Costa MMA, Ramos RKLG, Ferreira MR, Li Y, Bharath LP, Toolson E, Sebahar P, Looper RE, Jalili T, Rajasekaran NS, Jia Z, Symons JD, Pon Velayutham AB. 2017. Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial Dysfunction. Mol Nutr Food Res. doi: 10.1002/mnfr.201700601. |
29024402 |
Thiagarajan Sairam, Amit N Patel, Meenu Subrahmanian, Rajendran Gopalan, Steven M Pogwizd, Sudha Ramalingam, Sankaran Ramalingam, Rajasekaran NS (2018). Evidence for hyper-reductive redox in a subset of heart failure patients. Journal of Translational Medicine (In press). |
29022266 |
Narasimhan, M. and Rajasekaran, N.S., 2017. Cardiac Aging–Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling. In Exercise for Cardiovascular Disease Prevention and Treatment (pp. 231-255). Springer, Singapore. |
29022266 |
Narasimhan, M. and Rajasekaran, N.S., 2016. Exercise, Nrf2 and antioxidant signaling in cardiac aging. Frontiers in physiology, 7, p.241. |
29022266 |
Narasimhan, K.K.S., Jayakumar, D., Velusamy, P., Srinivasan, A., Mohan, T., Ravi, D.B., Uthamaraman, S., Sathyamoorthy, Y.K., Rajasekaran, N.S. and Periandavan, K., 2019. Morinda citrifolia and its active principle scopoletin mitigate protein aggregation and neuronal apoptosis through augmenting the DJ-1/Nrf2/ARE signaling pathway. Oxidative medicine and cellular longevity, 2019. |
28986357 |
Kain, V., Ingle, K.A., Kachman, M., Baum, H., Shanmugam, G., Rajasekaran, N.S., Young, M.E. and Halade, G.V., 2018. Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation. American Journal of Physiology-Heart and Circulatory Physiology, 314(2), pp.H160-H169. |
28986357 |
Quiles JM, Narasimhan M, Mosbruger T, Shanmugam G, Crossman D, Rajasekaran NS. 2017. Identification of transcriptome signature for myocardial reductive stress. Redox Biol. 13:568-580. |
28768233 |
McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME. 2017. Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. J Mol Cell Cardiol. 110:80-95. |
28736261 |
Quiles, J.M., Narasimhan, N., Shanmugam, G., Milash, B., Hoidal, J.R., and Rajasekaran NS. Differential Regulation of miRNA and mRNA Expression in the Myocardium of Nrf2 Knockout Mice. BMC Genomics. 2017 Jul 3;18(1):509. |
28673258 |
Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, and Rajasekaran NS. 2017. Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling. Frontiers in Physiology 8 (268). |
28515695 |
Gobinath Shanmugam, Madhusudhanan Narasimhan, Susan Tamowski, Victor Darley-Usmar, and Rajasekaran NS. 2017. Constitutive Activation of Nrf2 Induces a Stable Reductive State in the Mouse Myocardium. Redox Biology, 12;937–945. |
28482326 |
Ahmed, M.I., Guichard, J.L., Rajasekaran, N.S., Ahmad, S., Mariappan, N., Litovsky, S., Gupta, H., Lloyd, S.G., Denney, T.S., Powell, P.C. and Aban, I., 2016. Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function. The Journal of thoracic and cardiovascular surgery, 152(4), pp.1059-1070. |
27464577 |
Shanmugam G, Narasimhan M, Sakthivel R, Kumar R R, Davidson C, Palaniappan S, Claycomb WC, Hoidal JR, Darley-Usmar VM, Rajasekaran NS. A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes. Redox Biol. 2016 Jun 27; 9:77-89. |
27423013 |
Wende, A.R., Young, M.E., Chatham, J., Zhang, J., Rajasekaran, N.S. and Darley-Usmar, V.M., 2016. Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism. Free Radical Biology and Medicine, 100, pp.94-107. |
27242268 |
Patibandla, P.K., Rajasekaran, N.S., Shelar, S.B., Giridharan, G.A., Litovsky, S.H. and Sethu, P., 2016. Evaluation of the effect of diminished pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and function. The Journal of Heart and Lung Transplantation, 35(7), pp.930-932. |
27138701 |
Kumar, R.R., Narasimhan, M., Shanmugam, G., Hong, J., Devarajan, A., Palaniappan, S., Zhang, J., Halade, G.V., Darley-Usmar, V.M., Hoidal, J.R. and Rajasekaran, N.S., 2016. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. Journal of translational medicine, 14(1), pp.1-16. |
27048381 |
Swamy, S.M., Rajasekaran, N.S. and Thannickal, V.J., 2016. Nuclear factor–erythroid-2–related factor 2 in aging and lung fibrosis. The American journal of pathology, 186(7), pp.1712-1723. |
26839378 |
Narasimhan M, Shelar SB, Shanmugam G, Litovsky SH, Gounder SS, Karan G, Arulvasu C, Kensler TW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS.Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle.FASEB J. 2016 Feb 2. pii: fj.201500153. [Epub ahead of print]. |
26839378 |
Gomes AV, Rajasekaran NS, Pi X. Redox Signaling and the Cardiovascular and Skeletal Muscle System. Oxid Med Cell Longev. 2015;2015:849095. |
26523200 |
Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V, Zhang J.KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity.Biochem J. 2015 Aug 1;469(3):347-55. |
26205490 |
Verma DR, Khan MF, Tandar A, Rajasekaran NS, Neuharth R, Patel AN, Muhlestein JB, Badger RS.Nickel elution properties of contemporary interatrial shunt closure devices.J Invasive Cardiol. 2015 Feb;27(2):99-104. |
25661761 |
Narasimhan M, Rajasekaran NS.Reductive potential - a savior turns stressor in protein aggregation cardiomyopathy. Biochim Biophys Acta. 2015 Jan;1852(1):53-60. |
25446995 |
Haldar M, Kohyama M, So AY, Kc W, Wu X, Briseño CG, Satpathy AT, Kretzer NM, Arase H, Rajasekaran NS, Wang L, Egawa T, Igarashi K, Baltimore D, Murphy TL, Murphy KM.Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014 Mar 13;156(6):1223-34. |
24630724 |
Narasimhan M, Hong J, Atieno N, Muthusamy VR, Davidson CJ, Abu-Rmaileh N, Richardson RS, Gomes AV, Hoidal JR, Rajasekaran NS.Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells. Free Radic Biol Med. 2014 Jun;71:402-14. |
24613379 |
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