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Faculty Detail    
Name CRAIG L MAYNARD
 
Campus Address SHEL 613 Zip 2182
Phone  205-996-0136
E-mail  craigmaynard@uabmc.edu
Other websites
     

Education
Undergraduate  Midwestern State University    2001  B.S. 
Graduate  University of Alabama at Birmingham    2007  Ph.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Molecular & Cellular Pathology Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Assistant Professor

Graduate Biomedical Sciences Affiliations
Immunology 
Microbiology 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Maynard earned his Bachelor of Science degree in Biology from Midwestern State University and completed doctoral and postdoctoral training at the University of Alabama at Birmingham.

Society Memberships
Organization Name Position Held Org Link
American Association of Immunologists  Member  http://www.aai.org/ 
Society for Mucosal Immunology  Member  http://www.socmucimm.org/ 



Research/Clinical Interest
Title
Intestinal Immune Regulation in Health and Disease
Description
Crohn’s disease and ulcerative colitis - the two main types of inflammatory bowel disease (IBD) - are believed to be due in part to a failure of intestinal immune regulation, enabling aberrant pro-inflammatory responses to the intestinal microbiota to ensue. The establishment and maintenance of intestinal immune homeostasis requires the coordinated actions of multiple cellular mediators that mitigate unwanted responses to the vast community of beneficial microbes that inhabit our gastrointestinal tract. Intestinal regulatory T cells (Treg cells) Treg cells are essential for promoting and maintaining this host-microbiota mutualism and hold tremendous potential for therapeutic intervention/manipulation in IBD. Thus, one area of our work aims to define the cellular and molecular pathways that enhance regulatory T cell function during chronic gut inflammation. In addition, antibody-secreting plasma cells in the gut and associated lymphoid tissues help to control the interactions of luminal microbial antigens with the immune system. Therefore, we are also interested in understanding the host and/or microbial pathways that enable antibody-mediated control of the commensal microbiota and how perturbation of these processes predisposes to acute intestinal inflammation. We utilize a diverse combination techniques – cellular and molecular immunology, microbiology – as well as mutant and gnotobiotic rodent models.

Selected Publications 
Publication PUBMEDID
Maynard, C.L., Harrington, L.E., Janowski, K.M., Oliver, J.R., Zindl, C.L., Rudensky, A.Y., and Weaver, C.T. Interleukin 10-expressing regulatory T cells develop from Foxp3+ and Foxp3– precursors in the absence of interleukin 10. Nature Immunology 8 (9):931-941, (2007)  17694059 
Maynard, C.L. and Weaver, C.T. Diversity in the contribution of interleukin-10 to T-cell-mediated mediated immune regulation. Immunological Reviews 226 (1):219-233, (2008)  19161427 
Lee, Y., Turner, H., Maynard, C.L., Oliver, J.R., Chen, D., and Weaver, C.T. (2009). Late developmental plasticity in the T helper 17 lineage. Immunity 30 (1):92-107, (2009)  19119024 
Maynard, C.L. and Weaver, C.T. Intestinal Effector T Cells in Health and Disease. Immunity 31 (3):389-400, (2009)  19766082 
Palmer, M.T., Lee, Y.K., Maynard, C.L., Oliver, J.R., Bikle, D.D., Jetton, A.M., and Weaver, C.T. Lineage-specific effects of 1,25-dihydroxyvitamin D3 on the development of effector CD4 T cells. Journal of Biological Chemistry 286 (2):997-1004, (2011)  21047796 
Maynard, C.L., Hatton, R.D., Helms, W.S., Oliver, J.R., Stephensen, C.B., and Weaver, C.T. Contrasting Roles For All-Trans Retinoic Acid in TGF--mediated Induction of Foxp3 and Il10 genes in Developing Regulatory T Cells. Journal of Experimental Medicine 206 (2):343-357, (2009)  19204112 
Maynard, C.L., Elson, C.O., Hatton, R.D., and Weaver, C.T. Reciprocal Interactions of the Intestinal Microbiota and the Immune System in Homeostasis and Disease. Nature 489, 231–241, (2012)  22972296 
Zindl, C.L., Lai, J-F., Lee, Y.K., Maynard, C.L., Harbour, S.N., Ouyang, W., Chaplin, D.D., and Weaver, C.T. IL-22-Producing Neutrophils Contribute to Antimicrobial Defense and Restitution of Colonic Epithelial Integrity during Colitis. Proc Natl Acad Sci U S A. 110(31):12768-73 (2013)  23781104 
Harbour, S.N., Maynard, C.L., Zindl, C.L., Schoeb, T.R., and Weaver, C.T. The transition of Th17 cells into Th1-like progeny is required for the pathogenesis of colitis. PNAS 112(22):7061-6 (2015  26038559 
Kumar, R., Maynard, C.L., Eipers, P., Goldsmith, K.T., Ptacek, T., Grubbs, A., Dixon, P., Howard, D., Crossman, D.K., Crowley, M., Benjamin, W., Lefkowitz, E.J., Weaver, C.T., Rodriguez, J.M., and Morrow, C.D. Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficile. BMC Microbiology 16(1):5 (2016).  26758906 

Keywords
immunoregulation, microbiota, inflammatory bowel disease (IBD)