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Faculty Detail    
Name CHANDER RAMAN
  
Campus Address VH 557
Phone  (205) 934-2472
E-mail  craman@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Dermatology  Dermatology Professor
Secondary  Microbiology  Microbiology Professor
Center  Center for AIDS Research  Center for AIDS Research Professor
Center  Civitan International Research Center  Civitan International Research Center Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Neuroscience Center  Comprehensive Neuroscience Center Professor
Center  GL Ctr for Craniofacial, Oral, & Dental Disorders  GL Ctr for Craniofacial, Oral, & Dental Disorders Professor
Center  Multiple Sclerosis Center  Multiple Sclerosis Center Professor
Center  UAB Immunology Institute  UAB Immunology Institute Professor
Center  UWIRC Microbiome Center  UWIRC Microbiome Center Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Immunology 
Medical Scientist Training Program 
Neuroscience 

Biographical Sketch 
Chander Raman (b. 1961), Professor of Dermatology and Microbiology, received his B.Sc. degree in Zoology from Madras University, India (1980). He subsequently received his M.S. degree in Microbiology from Idaho State University (1984) and Ph.D. degree in Microbiology from Southern Illinois University (1989) with special emphasis in immunology and host responses to infectious diseases. During his postdoctoral training with Dr. Katherine Knight at Loyola University Chicago, Stritch School of Medicine (1984-1989), he developed an interest in immunogenetics and regulation of lymphocyte activation. He continued his studies first as an Assistant Scientist at Hospital for Special Surgery, Cornell University Medical College (1994-1996) and moved to University of Alabama at Birmingham, School of Medicine and is currently a Professor in the Department of Dermatology with a joint appointment in the Department of Microbiology.



Research/Clinical Interest
Title
Lymphocyte activation, immunopathogenesis of systemic and neuroimmune autoimmune disease, inflammatory diseases of the skin.
Description
Dr. Raman’s research focuses on immunopathogenesis of inflammatory and autoinflammatory diseases with a special interest in Multiple Sclerosis (MS), Hidradenitis Suppurativa (HS), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE). The projects are primarily human based followed by animal models for reductionist studies.

Selected Publications 
Publication PUBMEDID
Raman, C. and Kimberly, R. P. 1998. Differential CD5-dependent regulation of CD5-associated CK2 acitivity in mature and immature T cells – Implications on TCR/CD3-mediated activation. Cutting Edge-J. Immunol. 161-5817-5820.  9834058 
Raman, C., Kuo, A., Deshane, J., Litchfield, D. W., and Kimberly, R. P. Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5. 1998. J. Biol. Chem. 273:19183-19189.v  9668105 
John, B., Herrin, B. R., Raman, C., Wang, Y., Elder, H.K., Bobbit, K. R., Brody, B. A., and Justement, L. B. 2003. The B cells co-receptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J. Immunol. 170:3534-3543.  12646615 
Raman, C. 2002. CD5, an important regulator of lymphocyte selection and tolerance. Immunol. Res. 26:179-187  12403363 
Lu, X., Axtell, R. A., Collawn, J. F., Gibson, A., Justement, L. B., and Raman, C. 2002. AP2 Adaptor complex-dependent internalization of CD5: Differential regulation in T and B cells. J. Immunol.. 168:5612-5620.  12023358 
Greer, S. F., Raman, C. and Justement, L. B. 2001. CD45 function is regulated by an acidic 19 amino acid insert in domain II that serves as bidning and phosphoacceptor site for CK2. J. Immunol. 166:7208-7218.  11390469 
 

Keywords
Autoimmunity, Multiple Sclerosis, Skin inflammatory diseases