Genetics, Genomics and Bioinformatics  http://www.gbs.uab.edu  http://www.uab.edu/graduate  Back to Main

Faculty Detail    
Name CASEY T WEAVER
  
Campus Address BBRB 870 Zip 2170
Phone  (205) 975-5537
E-mail  cweaver@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Clinical Pathology  Anatomic Pathology Professor
Secondary  Med - Dev & Clin Immunology  Med - Dev & Clin Immunology Assistant Professor
Secondary  Microbiology  Microbiology Associate Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor
Center  Multiple Sclerosis Center  Multiple Sclerosis Center Professor
Center  Nephrology Research & Training Center  Nephrology Research & Training Center Professor
Center  UAB Immunology Institute  UAB Immunology Institute Professor

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 
Genetics, Genomics and Bioinformatics 
Hughes Med-Grad Fellowship Program 
Immunology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Weaver is the Wyatt and Susan Haskell Professor of Medical Excellence in the Department of Pathology. He received his BS and MD degrees from the University of Florida. His residency and post-doctoral training were completed at Barnes Hospital and Washington University. He was an Assistant Professor in the Department of Pathology at Washington University until joining UAB in 1992.



Research/Clinical Interest
Title
Control of Adaptive Immunity by CD4 T cells
Description
The research in my laboratory concerns the mechanisms by which CD4 T cells control adaptive immunity. Major current projects are: the generation and characterization of transgenic and knock-in mouse models for tracking T cell fate during CD4 effector and memory T cell development; studies defining mechanisms that control development and function of the Th17 effector lineage; development and function of regulatory T cells; characterization of mechanisms by which dysregulation of CD4 T cells leads to inflammatory bowel disease; and, characterization of the genetic elements that regulate cytokine gene expression in effector and regulatory T cells.

Selected Publications 
Publication PUBMEDID
Balasubramani A, Shibata Y, Crawford GE, Baldwin AS, Hatton RD, Weaver CT. Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity. (2010) 33:35-47.  20643337 
Mukasa R, Balasubramani A, Lee YK, Whitley SK, Weaver BT, Shibata Y, Crawford GE, Hatton RD, Weaver CT. Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. mmunity. (2010) 32:616-27.  20471290 
Maynard CL, Hatton RD, Helms WS, Oliver JR, Stephensen CB, Weaver CT. Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells. J Exp Med. (2009) 206:343-57.  19204112 
Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, Elson CO, Weaver CT. Late developmental plasticity in the T helper 17 lineage. Immunity. (2009) 30:92-107.  19119024 
Harrington LE, Janowski KM, Oliver JR, Zajac AJ, Weaver CT. Memory CD4 T cells emerge from effector T-cell progenitors. Nature. (2008) 52:356-60.  18322463 
Maynard CL, Harrington LE, Janowski KM, Oliver JR, Zindl CL, Rudensky AY, Weaver CT. Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol. (2007) 8:931-41.  17694059 
Weaver CT, Hatton RD, Mangan PR, Harrington LE . IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol. (2007) 25:821-52.  17201677 
Hatton RD, Harrington LE, Luther RJ, Wakefield T, Janowski KM, Oliver JR, Lallone RL, Murphy KM, Weaver CT. A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity. (2006) 25:717-29.  17070076 
Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. (2006) 441:231-4.  16648837 
Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. (2005) 6:1123-32.  16200070