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Faculty Detail    
Name LIZHONG WANG
 
Campus Address KAUL 740 Zip 0024
Phone  205-934-5948
E-mail  lwang12@uab.edu
Other websites
     

Education
Medical School  China Medical University    1988  M.D. 
Graduate  Akita University, Japan    2002  Ph.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Genetics   Genetics Research Div Associate Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Associate Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor

Graduate Biomedical Sciences Affiliations
Genetics, Genomics and Bioinformatics 

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research     
American Association for the Advancement of Science     



Research/Clinical Interest
Title
Cancer Genetics
Description
Our research interests focus on the cancer genetics and molecular epidemiology involved in prostate cancer and breast cancer. Our recent research showed that the somatic genetic alterations in a novel tumor suppressor gene FOXP3 with a single-hit mechanism have an important impact on developing both breast cancer and prostate cancer. We are going to investigate the molecular mechanisms of tumor development and progression in multiple signaling pathways. Our current projects include 1) identifying the cancer-causing genes, targets, and pathways; 2) determining the genetic mechanism of tumor invasion and metastasis; 3) establishing the principle of tumor suppressors relay between FOXP3 and noncoding RNA; 4) developing human-like animal models of prostate cancer.

Selected Publications 
Publication PUBMEDID
Complete list of my published work in MyBibliography:
http://www.ncbi.nlm.nih.gov/sites/myncbi/lizhong.wang.1/bibliography/43154619/public/?sort=date&direction=descending
 
 
Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MWY, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang THM, Yang T, Park BK, Wang CY, Zheng P, Liu Y. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell, 2007 June 29; 129 (7): 1275-86.

Wang L, Liu R, Li W, Chen C, Katoh H, Chen GY, McNally B, Lin L, Zhou P, Zuo T, Cooney KA, Liu Y, Zheng P. Somatic Single-hits Inactivate the X-linked Tumor Suppressor FOXP3 in the Prostate. Cancer Cell, 2009 Oct 6; 16 (4):336-46.

Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res. 2011 Mar 15; 71 (6): 2162-71.

Wang L, Liu R, Ye P, Wong C, Chen GY, Zhou P, Sakabe K, Zheng X, Wu W, Zhang P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015 Jan 20;6:5909.

Liu R, Yi B, Wei S, Yang WH, Hart KM, Chauhan P, Zhang W, Mao X, Liu X, Liu CG, Wang L. FOXP3-microRNA-146-NFkB axis and therapy for precancerous lesions in prostate. Cancer Res. 2015 Apr 15;75(8):1714-24.

Liu R, Liu C, Chen D, Yang WH, Liu X, Liu CG, Dugas CM, Tang F, Zheng P, Liu Y, Wang L. FOXP3 controls an miR-146/NFkB negative feedback loop that inhibits apoptosis in breast cancer cells. Cancer Res. 2015 Apr 15;75(8):1703-13.

Zhang W, Yi B, Wang C, Chen D, Bae S, Wei S, Guo RJ, Lu C, Nguyen LL, Yang WH, Lillard JW, Zhang X, Wang L, Liu R. Silencing of CD24 Enhances the PRIMA-1-Induced Restoration of Mutant p53 in Prostate Cancer Cells. Clin Cancer Res. 2016 May 15;22(10):2545-54.

Zhang G, Zhang W, Li B, Stringer-Reasor E, Chu C, Sun L, Bae S, Chen D, Wei S, Jiao K, Yang WH, Cui R, Liu R, Wang L. MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. Breast Cancer Res. 2017 Jun 21;19(1):73.

Wu L, Yi B, Wei S, Rao D, He Y, Naik G, Bae S, Liu XM, Yang WH, Sonpavde G, Liu R, Wang L. Loss of FOXP3 and TSC1 Accelerates Prostate Cancer Progression through Synergistic Transcriptional and Posttranslational Regulation of c-MYC. Cancer Res. 2019 Feb 7. doi: 10.1158/0008-5472.CAN-18-2049. [Epub ahead of print] PMID: 30733194 
http//wwwncbinlmnihgov/pubmed?term=lizhong%20 

Keywords
Tumor Suppressor Gene, Tumor Development and Progression, Cancer Genetics