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Faculty Detail    
Name CARMEL M MCNICHOLAS-BEVENSEE
  
Campus Address SHPB 451
Phone  (205) 934-1785
E-mail  cbevense@uab.edu
Other websites
     

Education
Undergraduate  University of Manchester, UK    1989  B.Sc. 
Graduate  University of Manchester, UK    1992  Ph.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Secondary  Biomedical & Health Sciences MS Program  Biomedical & Health Sciences MS Program Associate Professor
Secondary  Dept of Medical Education  Dept of Medical Education Associate Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Associate Professor
Center  Ctr for Interprof Educ and Simulation  Ctr for Interprof Educ and Simulation Associate Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Associate Professor

Graduate Biomedical Sciences Affiliations
Integrative Biomedical Sciences 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Carmel McNicholas-Bevensee, Instructor, received both her B.Sc. (Hons) degree (1989) and Ph.D. (1992) from the University of Manchester (England). After completing her postdoctoral training in the Department of Cellular and Molecular Physiology at Yale University in the laboratory of Dr. Gerhard Giebisch, she worked as Research Investigator II for Bristol-Myers Squibb Pharmaceutical Research Institute. She joined the UAB faculty in 2000.



Research/Clinical Interest
Title
Regulation of ion channels
Description
My research interest focuses on the regulation and biophysical characterization of ion channels. We examine the impact of inflammation and tissue remodeling on the electrophysiological profile of and airway cells. Studies include examining effects of release of inflammatory mediators on CFTR ion channel function in airway cells. A new area of research is to isolate and characterize CFTR ion channel function in the human sweat gland.

Selected Publications 
Publication PUBMEDID
†Roux, J., †McNicholas, C.M., †Carles, M., Goolaerts, A., Houseman, B.T., Dickinson, D.A., Iles, K.E., Ware, L.B., Matthay, M.A., Pittet, J.-F. IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. (2013) FASEB J 27(3): 1095-106 † denotes equal contribution.  23221335  
Lambert, J.A., Raju, S.V., Tang, L.P., McNicholas, C.M., Li, Y., Courville, C.W., Faris, R.F., Coricor, G.E., Smoot, L.H., Mazur, M.M., Dransfield, M.T., Bolger, G.B., and Rowe, S.M. (2013) CFTR Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis. Am. J.Resp. Cell. Molec. Biol. 10.1165/rcmb.2013-0228OC  24106801  
Zhang, S., Blount, A.C., McNicholas, C.M., Skinner, D.F., Chestnut M., Kappes, J.C., Sorscher, E.J., Woodworth, B.A. (2013) Resveratrol Enhances Airway Surface Liquid Depth in Sinonasal Epithelium by Increasing Cystic Fibrosis Transmembrane Conductance Regulator Open Probability. PLoS ONE 8(11): e81589.  24282612  
Zhang, S., Skinner, D., Hicks, B., Bevensee, M.O., Sorscher, E.J., Lazrak, A., Matalon, S.,McNicholas, C.M., and Woodworth, B.A. (2014) Sinupret® Activates CFTR and TMEM16A-Dependent Transepithelial Chloride Transport and Improves Indicators of Mucociliary Clearance PLoS One DOI: 10.1371/journal.pone/  0104090 
Hickman-Davis, J.M., McNicholas-Bevensee, C., Davis, I.C., Ma, H.P., Davis, G.C., Bosworth, C.A. & Matalon S. Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. Am J Respir Crit Care Med 173: 334-344, 2006.  16254273 
McAlear, S.D., Liu, X., Williams, J.B., McNicholas-Bevensee, C.M. & Bevensee M.O. Electrogenic Na/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: functional comparison and roles of the amino and carboxy termini. J Gen Physiol 127: 639-658, 2006.  16735752 
McNicholas-Bevensee, C.M., DeAndrade, K.B., Bradley, W.E., Dell'Italia, L.J., Lucchesi, P.A. and Bevensee, M.O. Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure. Cardiovasc Res 72: 262-270, 2006.  16959228 
Wu, J., McNicholas, C.M. and Bevensee, M.O. (2009) Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 106, 14150-5.   19667194 
McNicholas, C.M., Berecek, K.H. Mammalian target of rapamycin: MasTOR mediator of cellular changes in pathological states? Hypertension 54 (6):1221-2, 2009  19884561 
Kapoor, N., Lee, W., Clark, E., Bartoszewski, R., McNicholas, C.M., Latham, C.B., Bebok, Z., Parpura,V., Fuller,C.M., Palmer, C.A. and Benos, D.J. Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes. Am J Physiol Cell Physiol 300: C1246-1259, 2011.  21346156 
Rooj, A.K., McNicholas, C.M., Bartoszweski, R., Bebok, Z. Benos, D.J. and Fuller, C.M. Glioma specifica cation conductance regulates migration and cell cycle progression. J Biol Chem 287(6): 4053-65, 2012.   22130665 
Raju, S.V., Jackson, P.L., Courville, C.A., McNicholas, C.M., Sloane, P.A., Sabbatini, G., Tidwell, S., Tang, L.P., Liu, B., Fortenberry, J.A., Jones, C.W., Boydston, J.A., Clancy, J.P., Bowen, L., Accurso, F.J., Blalock, J.E., Dransfield, M.T., Rowe, S.M. (2013) Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function. Am J Respir Crit Care Med Sept 16   24040746 
Wells, J.M., O’Reilly P.J., Szul, T., Sullivan, D.I., Handley, G., Garrett, C., McNicholas-Bevensee, C.M., Roda, M.A., Miller, B.E., Tal-Singer, R., Gaggar, A., Rennard, S.I., Jackson, P.L. and Blalock, J.E. (2014). An Aberrant Leukotriene A4 Hydrolase-PGP Pathway in the Pathogenesis of Chronic Obstructive Pulmonary Disease. Epub: Am J Respir Crit Care Med PMID: 24874071  24874071 
Rooj, A.K., Liu, Z., McNicholas, C.M. and Fuller, C.M. (2015) Physical and Functional Interaction between a Glioma Cation Channel and Integrin b1 Require a-Actinin. Am J Physiol Cell Physiol (2015) 309(5):C308-19  26108662 
Reddy, B.G., Dai, Q, McNicholas, C.M., Fuller, C.M., Kappes, J.C., and DeLucas, L.J. (2016) Expression and Purification of the alpha subunit of the epithelial sodium channel, ENaC. Protein Expr Purif.;117:67-75.  26394093 
Raju, S.V., Lin, V.Y., Liu, L., McNicholas C.M., Karki, S., Sloane P.A., Tang, L.P., Jackson, P.L., Wang, W., Wilson, L., Mazur, M., Kappes, J., Tearney, G.T., Rowe, S.M. The CFTR Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Acute and Chronic CFTR Inhibition by Cigarette Smoke. (2017) Am J Respir Cell Mol Biol 56(1): 99-108.  27585394 
Sabusap, C., Wang, W., McNicholas, C.M, Chung, W.J., Fu, L., Wen, H., Mazur, M., Kirk, K.L. Collawn, J. Hong, J., Sorscher, E. Analysis of Cystic Fibrosis-Associated P67L CFTR Illustrates Barriers to Personalized Therapeutics for Orphan Diseases. (2016) JCI Insight 8: 1 (14)   27660821 
Genschmer, K. R., Russell, D. W., Lal, C., Szul, T., Bratcher, P. E., Noerager, B. D., Abdul Roda, M., Xu, X., Rezonzew, G., Viera, L., Dobosh, B. S., Margaroli, C., Abdalla, T. H., King, R. W., McNicholas, C. M., Wells, J. M., Dransfield, M. T., Tirouvanziam, R., Gaggar, A. and Blalock, J. E. Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung (2019) Cell 176 (1-2): 113-126   30633902 
Roda, M.A., Xu, X., Abdalla, T.H., Sadik, M., Szul, T., Bratcher, P.E., Viera, L., Solomon, G.M., Wells, J.M., McNicholas, C.M., Redegeld, F.A., Folkerts, G., Blalock, J.E., and Gaggar, A. Proline-Glycine-Proline Peptides are Critical in the Development of Smoke-Induced Emphysema. (2019) Am. J. Resp. Cell Mol. Biol. 61 (5): 560-566  30958968 
McNicholas, C.M. Beyond Cystic Fibrosis Transmembrane Regulator (CFTR) Single Channel Kinetics: Implications for Therapeutic Intervention. (2017) J. Physiol. 595(4):1015-1016.   5309350 
 

Keywords
Ion channel, Pulmonary, Cardiovascular, Sweat gland