Cell, Molecular, & Developmental Biology  http://www.gbs.uab.edu  http://www.uab.edu/graduate  Back to Main

Faculty Detail    
Name SHAWN R GILBERT
  
Campus Address ACC 316 Zip 0011
Phone  (205) 975-7499
E-mail  shawng@uab.edu
Other websites
     

Education
Medical School  University of North Carolina Chapel Hill    1996  MD 
Graduate  University of North Carolina Hospital    1997  MD 
Residency  University of North Carolina     2002  Orthopedic Surgery 
Fellowship  Children's Hospital of Atlanta    2003  Pediatric Orthopedic Surgery 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Orthopaedic Surgery  Orthopaedic Surgery Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Secondary  Joint Pathology  Molecular & Cellular Pathology Assistant Professor
Center  Biomatrix Eng Regen Med (BERM) Ctr  Biomatrix Eng Regen Med (BERM) Ctr Professor
Center  Comp Arthritis, MSK, Bone & Autoimmunity Ctr  Comp Arthritis, MSK, Bone & Autoimmunity Ctr Professor
Center  Comprehensive Diabetes Center  Comprehensive Diabetes Center Professor
Center  Ctr for Clinical & Translational Sci  Ctr for Clinical & Translational Sci Professor
Center  Nutrition Sciences Research  Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology 

Biographical Sketch 
EDUCATION: University of North Carolina School of Medicine M.D. with Honors, 1996 University of North Carolina at Chapel Hill B.S. Biology with Distinction and Highest Honors, 1992 AWARDS/HONORS: Vern Tolo Basic Science Paper Award - Recognizes outstanding basic science presentation at annual meeting of Pediatric Orthopaedic Society of North America, 2009. St. Giles Young Investigator Award – Awarded by Pediatric Orthopaedic Society of North America to a promising young investigator in the field of Pediatric Orthopaedics, 2009. Most outstanding teaching performance by a resident – Musculoskeletal course for second year medical students, UNC School of Medicine, 1998 POSTDOCTORAL TRAINING: 2002-2003 Fellowship, Pediatric Orthopaedic Surgery Children’s Healthcare of Atlanta 1996-2002 Residency, Orthopaedic Surgery UNC Hospitals Research track



Research/Clinical Interest
Title
Description
I have two foci of basic science research. My principal interest has been investigating the role of the hypoxia inducible factor (HIF) pathway and angiogenesis in the skeleton. I am pursuing a line of investigation that angiogenesis drives osteogenesis, both during development and repair. I am using genetic mouse models and pharmacologic interventions to increase angiogenesis by targeting HIF. I have also identified additional HIF activating pro-angiogenic compounds that are under development. I have recently developed a new translational research interest in obesity and musculoskeletal health. I am pursuing both clinical studies and animal studies to examine musculoskeletal health (outcomes measures), injuries and mechanisms that predispose to injury or impair recovery. Additional clinical research interests include publications and presentations on limb and spine deformity, fractures, skeletal maturation, and musculoskeletal infections, and an ongoing randomized clinical trial comparing bracing styles for clubfeet.

Selected Publications 
Publication PUBMEDID
Dietrich LN, Reid D, Doo D, Fineberg NS, Khoury JG, Gilbert SR. Predicting MSSA in Acute Hematogenous Osteomyelitis in a Setting With MRSA Prevalence. J Pediatr Orthop. 2014 Aug 28. [Epub ahead of print]  25171681 
Theriault JR, Perez J, Gilbert S, Palmer M, Schreiber SL, Lindsley CW, Dawson ES, Engers JL, Felts AS, Bates BS, Emmitte KA. Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway. 2011 Mar 31 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda
(MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK143197/ 		 23762956 
Culotta BA, Gilbert SR, Sawyer JR, Ruch A, Sellers T. Weight gain during external fixation. J Child Orthop. 2013 Mar;7(2):147-50. doi:10.1007/s11832-012-0468-1. Epub 2012 Nov 30  24432073 
Gilbert SR, MacLennan PA, Backstrom I, Creek A, Sawyer J. Altered lower extremity fracture characteristics in obese pediatric trauma patients. J Orthop Trauma. 2015 Jan;29(1):e12-7. doi: 10.1097/BOT.0000000000000132. PubMed Central PMCID: PMC4198524  24740109 
Chong DY, Finberg NS, Conklin MJ, Doyle JS, Khoury JG, Gilbert SR. Prospective evaluation of the use of Mitchell shoes and dynamic abduction brace for idiopathic clubfeet. J Pediatr Orthop B. 2014 Nov;23(6):501-4. doi:
10.1097/BPB.0000000000000090 		 25144885 
 

Keywords
HIF, angiogenesis, bone, obesity, fracture