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Faculty Detail    
Name SURESH B BOPPANA
  
Campus Address CHB 114 Zip 0011
Phone  (205) 996-7765
E-mail  sboppana@peds.uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Ped - Infectious Disease  Ped - Infectious Disease Professor
Secondary  Microbiology  Microbiology Professor
Center    Professor
Center  Center for Women's Reproductive Health  Center for Women's Reproductive Health Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Minority Health & Research Center  Minority Health & Research Center Professor
Center  UAB Immunology Institute  UAB Immunology Institute Professor

Graduate Biomedical Sciences Affiliations
Immunology 
Microbiology 

Society Memberships
Organization Name Position Held Org Link
American Academy of Pediatrics  Fellow   
American Pediatric Society  Member   
American Society of Microbiology  Member   
Infectious Diseases Society of America  Fellow   
Pediatric Infectious Disease Society  Member   
society for Pediatric Research  Member   
 



Research/Clinical Interest
Title
Pathogenesis of maternal and congenital CMV infections
Description
Dr. Boppana has been studying the natural history and pathogenesis of maternal and congenital human cytomegalovirus (HCMV) infection for the past 20 years. His research interests include the definition of the mechanisms of intrauterine transmission of CMV, pathogenesis of congenital CMV infection, understanding the CMV strain diversity and reinfections and the consequences of such reinfections in relation to fetal outcome. His work challenged the dogma that children with congenital CMV infection born to women with primary CMV infection during pregnancy experience most of the disease burden from this intrauterine infection. His research in collaboration with Dr. William Britt has documented the impact of congenital CMV infection in highly seropositive settings including developing countries. He has shown that CMV reinfections occur frequently in healthy seropositive women and such reinfections could lead to intrauterine infection, symptomatic disease and sequelae.

Selected Publications 
Publication PUBMEDID
Pati SK, Novak Z, Purser M, Arora N, Mach M, Britt WJ, Boppana SB. Strain-specific neutralizing antibody responses against the human cytomegalovirus envelope glycoprotein N (gN). Clin Vaccine Immunol 19:909-913, 2012. PMID: 22492744   
Boppana SB, Ross SA, Novak Z, Shimamura M, Tolan RW, Palmer AL, Ahmed A, Michaels MG, Sanchez PJ, Bernstein DI, Britt WJ, Fowler KB. Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection. JAMA 303 (14):1375-1382, 2010. PMCID:PMC2997517, PMID: 20388893

Boppana SB, Fowler KB, Ross SA. Screening newborns for congenital cytomegalovirus infection—Reply. JAMA 304 (4):408, 2010

Arora N, Novak Z, Fowler KB, Boppana SB, Ross SA. Cytomegalovirus viruria and DNAemia in healthy seropositive women. J Infect Dis 202(12):1800-3, 2010. PMCID:PMC2988109, PMID: 21050121

4. Atkinson TP, Boppana S, Theos A, Clements S, Li X, Waites K. Stevens-Johnson syndrome in a patient with macrolide-resistant mycoplasma pneumoniae Pneumonia. Pediatrics, 127(6):e1605-9, 2011 [Epub May 2, 2011]. PMID:2153661

5. Boppana SB, Ross SA, Shimamura M, Palmer AL, Ahmed A, Michaels MG, Sanchez PJ, Bernstein DI, Tolan RW, Novak Z, Chowdhury N, Britt WJ, Fowler KB. Saliva polymerase chain reaction assays for newborn cytomegalovirus screening. N Engl J Med 364:2111-2118, 2011. PMID:21631323

6. Novak Z, Chowdhury N, Ross SA, Pati SK, Fowler KB, Boppana SB. Diagnostic consequences of cytomegalovirus glycoprotein B polymorphisms. J Clin Microbiol 49(8):3033-3035, 2011. PMID:21653769

Ross SA, Novak Z, Pati S, Patro RK, Blumenthal J, Danthaluri VR, Ahmed A, Michaels MG, Sánchez PJ, Bernstein DI, Tolan RW, Palmer AL, Britt WJ, Fowler KB, Boppana SB. Mixed infection and strain diversity in congenital cytomegalovirus infection. J Infect Dis 204(7):1003-1007, 2011 PMID: 21881114

Yamamoto AY, Mussi-Pinhata MM, de Carvalho e Oliveira PF, Isaac MDL, Aragon DC, da Silva Manfredi AK, Boppana SB, Britt WJ. Congenital cytomegalovirus infection as a cause of sensorineural hearing loss in a highly immune population. Pediatr Infect Dis J 30(12):1043-1046, 2011. PMID: 21814153

Ross SA, Novak Z, Pati SK, Boppana SB. Overview of the diagnosis of cytomegalovirus infection. Infect Disord Drug Targets 11:466-474, 2011. PMID: 21827433

Pati SK, Novak Z, Purser M, Arora N, Mach M, Britt WJ, Boppana SB. Strain-specific neutralizing antibody responses against the human cytomegalovirus envelope glycoprotein N (gN). Clin Vaccine Immunol 19:909-913, 2012. PMID: 22492744 		  
Boppana SB, Fowler KB, Britt WJ, Stagno S, Pass RF: Symptomatic congenital cytomegalovirus infection in infants born to mothers with preexisting immunity to cytomegalovirus. Pediatrics 104:55-60, 1999

 		  
Boppana SB, Rivera LB, Fowler KB, Yang JP, Pass RF, Mach M, Britt WJ: Role of maternal reinfection in intrauterine transmission of human cytomegalovirus (HCMV) in women with preconceptional immunity. New Engl J Med, 344: 1366-1371, 2001


 		  
Rivera LB, Boppana SB, Britt WJ, Stagno S, Pass RF, Fowler KB. Predictors of sensorneural hearing loss in children with symptomatic congenital cytomegalovirus infection. Pediatrics 110:762-767, 2002.

 		  
Boppana SB, Fowler KB, Rivera LB, Yang J, Pass RF, Britt WJ. Association between virus burden in early infancy and outcome in children with congenital cytomegalovirus infection. J Pediatr 146:817-823, 2005.   
Birth prevalence and natural history of congenital cytomegalovirus infection in a highly seroimmune population. Mussi-Pinhata MM, Yamamoto AY, Moura Brito RM, de Lima Isaac M, de Carvalho e Oliveira PF, Boppana S, Britt WJ. Clin Infect Dis 49:522-528, 2009
 		  
Boppana SB, Ross SA, Novak Z, Shimamura M, Tolan RW, Palmer AL, Ahmed A, Michaels MG, Sanchez PJ, Bernstein DI, Britt WJ, Fowler KB. Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection. JAMA 303 (14):1375-1382, 2010. PMCID:PMC2997517, PMID: 20388893   
Cytomegalovirus reinfections in healthy seroimmune women. Ross SA, Arora N, Novak Z, Fowler KB, Britt WJ, Boppana SB. J Infect Dis 201: 386-9, 2010.   
Boppana SB, Ross SA, Shimamura M, Palmer AL, Ahmed A, Michaels MG, Sanchez PJ, Bernstein DI, Tolan RW, Novak Z, Chowdhury N, Britt WJ, Fowler KB. Saliva polymerase chain reaction assays for newborn cytomegalovirus screening. N Engl J Med 364:2111-2118, 2011. PMID:21631323   
Ross SA, Novak Z, Pati S, Patro RK, Blumenthal J, Danthaluri VR, Ahmed A, Michaels MG, Sánchez PJ, Bernstein DI, Tolan RW, Palmer AL, Britt WJ, Fowler KB, Boppana SB. Mixed infection and strain diversity in congenital cytomegalovirus infection. J Infect Dis 204(7):1003-1007, 2011 PMID: 21881114   
Yamamoto AY, Mussi-Pinhata MM, de Carvalho e Oliveira PF, Isaac MDL, Aragon DC, da Silva Manfredi AK, Boppana SB, Britt WJ. Congenital cytomegalovirus infection as a cause of sensorineural hearing loss in a highly immune population. Pediatr Infect Dis J 30(12):1043-1046, 2011. PMID: 21814153   
 

Keywords
Conenital infectionm CMV, hearing loss, newborn CMV screening, CMV reinfection