Undergraduate |
Worcester Polytechnic Institute |
|
1987 |
BS |
Graduate |
University of Alabama at Birmingham |
|
1996 |
PhD |
|
Appointment Type |
Department |
Division |
Rank |
Primary |
Clinical Pathology |
Anatomic Pathology |
Associate Professor |
Center |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Comp Arthritis, MSK, Bone & Autoimmunity Ctr |
Associate Professor |
Center |
UAB Immunology Institute |
UAB Immunology Institute |
Associate Professor |
|
Molecular and Cellular Pathology Program |
|
Publication |
PUBMEDID |
Harbour, S.N., DiToro, D.F., Witte, S.J., Zindl, C.L., Gao, M., Schoeb, T.R., Jones, S.A., Hatton, R.D., and Weaver, CT. TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity. Sci Immunol. 2020 Jul 17, 5(49).eaaw2262 |
32680955 |
DiToro, D., Harbour, S.N., Bando, J.K., Benavides, G., Witte, S., Laufer, VA, Moseley, C., Singer, J.R., Frey, B., Turner, H., Bruning, J., Darley-Usmar, B., Gao, M., Conover, C., Hatton, R.D., Colonna, F.S. and Weaver, C.T.. Insulin-like growth factors are key regulators of T helper 17 regulatory T cell balance in autoimmunity. Immunity. 2020 Apr 14, 52(4):650-667.e10. |
32294406 |
Pham, D., Moseley, C.E., Gao, M., Savic, D., Winstead, C.J., Sun, M., Kee, B.L., Myers, R.M., Weaver, C.T., Hatton, R.D.: Batf pioneers the reorganization of chromatin in developing effector T cells via Ets1-dependent recruitment of Ctcf. Cell Rep. 2019 Oct 29:29(5):1203-1220. |
31665634 |
DiToro, D., Winstead, C.J., Pham, D. Witte, S., Andargachew, R., Singer, J.R., Wilson, C.G., Zindl, C. L., Luther, R.L., Silberger, D.J., Weaver, B.T., Kolawole, E.M., Martinez, R.J., Turner, H., Hatton, R.D., Moon, J.J., Way, S.S., Evavold, B.D., and Weaver, C.T. Differential IL-2 expression defines developmental fates of follicular versus non-follicular helper T cells. Science. 2018. Sep14;361(6497). |
30213884 |
Whitley, S.K., Balasubramani, A., Zindl, C.L., Sen, R., Shibata, Y., Crawford, G.E., Weathington, N.M., Hatton, R.D., Weaver, C.T.. IL-1R signaling promotes STAT3 and NF-kB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transtription. J Biol Chem. 2018. Oct 12, 293(41):15790-15800. |
30093408 |
Basu R., Whitley, S.K., Bhaumik, S., Zindl, C.L., Schoeb, T.R., Benveniste, E.N., Pear, W.S., Hatton, R.D., and Weaver, C.T. 2015. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol. 16(3):286-95. |
25642823 |
Balasubramani, A., Winstead, C.J., Turner, H., Janowski, K.M., Harbour, S.N., Shibata, Y., Crawford, G.E., Hatton, R.D., and Weaver, C.T. 2014. Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. PLoS Genet 10(1):e1003969 |
24415943 |
Bailis, W., Yashiro-Ohtani, Y., Fant, T.C., Hatton, R.D., Weaver, C.T., Artis, D., and Pear, W.S. 2013. Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity 39(1):145-59 |
23890069 |
Basu, R., O’Quinn, D.B., Silberger, D.J., Schoeb, T.R., Fouser, L., Ouyang, W., Hatton, R.D., and Weaver, C.T. 2012. Th22 Cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity. 37(6):1061-75. |
23200827 |
Maynard, C.L., Elson, C.O., Hatton, R.D., and Weaver, C.T. 2012. Reciprocal interactions of the intestinal microbiota and immune system. Nature 489:231-41. |
22972296 |
Hatton, R.D. 2011. TGF-beta in Th17 Cell Development: The Truth is Out There. Immunity 34(3):288-90. |
21435582 |
Balasubramani, A., Mukasa, R., Hatton, R.D., and Weaver, C.T.: Regulation of the Ifng locus in the context of T-lineage specification and plasticity. Immunol. Rev 2010 Nov;238(1):216-32. |
2096959 |
Balasubramani, A., Shibata, Y., Crawford, G.E., Baldwin, A.S., Hatton, R.D.*, and Weaver, C.T.*: Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity 2010 Jul 23;33(1):35-47. *contributed equally |
20643337 |
Mukasa, R., Balasubramani, A., Lee, Y.K., Whitley, S.K., Weaver, B.T., Shibata, Y., Crawford, G.E., Hatton, R.D.*, and Weaver, C.T.*: Epigenetic instability of cytokine and transcription factor gene loci underlie plasticity of the T helper 17 lineage. Immunity 2010 May 28;32(5):616-27. *contributed equally |
2047129 |
Weaver, C.T. and Hatton, R.D.: Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol. 2009 Dec;9(12):883-9. |
19935807 |
Schraml, B.U., Hildner, K., Ise, W., Lee, W.L., Smith, W.A., Solomon, B., Sahota, G., Sim, J., Mukasa, R., Cemerski, S., Hatton, R.D., Stormo, G.D., Weaver, C.T., Russell, J.H., Murphy, T.L., Murphy, K.M. : The AP-1 transcription factor Batf control T(H)17 differentiation. Nature. 2009 Jul 16;460(7253):405-9. |
19578362 |
Lee, Y.K., Mukasa, R., Hatton, R.D., Weaver, C.T.: Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol. 2009 Jun;21(3):274-80. |
19524429 |
Maynard CL, Hatton RD, Helms WS, Oliver JR, Stephensen CB, Weaver CT. Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells. J Exp Med. 2009 Feb 16;206(2):343-57. Epub 2009 Feb 9. |
19204112 |
Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages. Annu Rev Immunol. 2007 Jan 2; [Epub ahead of print] |
17201677 |
Hatton RD, Harrington LE, Luther RJ, Wakefield T, Janowski KM, Oliver JR, Lallone RL, Murphy KM, Weaver CT. A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity. 2006 Nov;25(5):717-29. Epub 2006 Oct 26. |
17070076 |
Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 2006 May 11;441(7090):231-4. |
16648837 |
Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005 Nov;6(11):1123-32. |
16200070 |
Cong Y, Konrad A, Iqbal N, Hatton RD, Weaver CT, Elson CO. Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. J Immunol. 2005 Mar 1;174(5):2787-95.
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15728488 |
Kubo T, Hatton RD, Oliver J, Liu X, Elson CO, Weaver CT. Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J Immunol. 2004 Dec 15;173(12):7249-58. |
15585847 |
Hatton, R.D, and Weaver, C.T.: T-bet or not T-bet. Science 302: 993, 2003. |
14605354 |
Hurez, V., Hatton, R.D., Oliver, J., Matthews, R.J., Weaver, C.T.: Gene delivery into primary T cells: Overview and characterization of a transgenic model for efficient adenovirial transduction. Immunol. Research, 26(1-3): 131, 2002.
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12403352 |
Hurez V.*, Dzialo-Hatton R.*, Oliver J., Matthews R.J., Weaver C.T.: Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model. BMC Immunology (2002) 3:4 (02 May 2002). *contributed equally. |
12019030 |
Dzialo-Hatton R, Milbrandt J, Hockett RD Jr, Weaver CT.: Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members. J Immunol. 2001 Apr 1;166(7):4534-42. |
11254710 |
Duality in the Th17-Treg developmental decision Robin D Hatton and Casey T Weaver F1000 Biology Reports 2009, 1:5 (21 January 2009)
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