Undergraduate |
Universidad Nacional de Cordoba, Argentina |
|
1986 |
BS, MS |
Graduate |
Universidad Nacional de Cordoba, Argentina |
|
1989 |
PhD |
|
Cell, Molecular, & Developmental Biology |
Cellular and Molecular Biology Program |
Comprehensive Neuroscience Center |
Genetics, Genomics and Bioinformatics |
Hughes Med-Grad Fellowship Program |
Integrative Biomedical Sciences |
Medical Scientist Training Program |
Neuroscience |
Neuroscience Graduate Program |
Neurosciences |
|
Publication |
PUBMEDID |
Xu X, Pozzo-Miller L. EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice. J Physiol. 2017 Jun 16. doi: 10.1113/JP274450. [Epub ahead of print] |
28621434 |
Li W, Bellot-Saez A, Phillips ML, Yang T, Longo FM, Pozzo-Miller L. A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice. Dis Model Mech. 2017 Jul 1;10(7):837-845 |
28679669 |
Xu X, Garcia J, Ewalt R, Nason S, Pozzo-Miller L. The BDNF val-66-met Polymorphism Affects Neuronal Morphology and Synaptic Transmission in Cultured Hippocampal Neurons from Rett Syndrome Mice. Front Cell Neurosci. 2017 Jul 13;11:203 |
28751857 |
Li W, Xu X, Pozzo-Miller L. Excitatory synapses are stronger in the hippocampus of Rett syndrome mice due to altered synaptic trafficking of AMPA-type glutamate receptors. Proc Natl Acad Sci U S A. 2016 Feb 29. pii: 201517244. [Epub ahead of print] |
26929363 |
Pozzo-Miller L, Pati S, Percy AK. Rett Syndrome: Reaching for Clinical Trials. Neurotherapeutics. 2015 Jul;12(3):631-40. |
25861995 |
Phillips M, Pozzo-Miller L. Dendritic spine dysgenesis in autism related disorders. Neurosci Lett. 2015 Aug 5;601:30-40. |
25767435 |
Xu X, Miller EC, Pozzo-Miller L. Dendritic spine dysgenesis in Rett syndrome. Front Neuroanat. 2014 Sep 10;8:97. |
25309341 |
Calfa G, Li W, Rutherford JM, Pozzo-Miller L. Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice. Hippocampus. 2015 Feb;25(2):159-68. |
25209930 |
Xu X, Kozikowski AP, Pozzo-Miller L. A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome. Front Cell Neurosci. 2014 Mar 7;8:68. |
24639629 |
Li W, Pozzo-Miller L. BDNF deregulation in Rett syndrome. Neuropharmacology. 2014 Jan;76 Pt C:737-46. |
23597512 |
Li W, Calfa G, Larimore J, Pozzo-Miller L. Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17087-92. |
23027959 |
Chapleau CA, Boggio EM, Calfa G, Percy AK, Giustetto M, Pozzo-Miller L. Hippocampal CA1 pyramidal neurons of Mecp2 mutant mice show a dendritic spine phenotype only in the presymptomatic stage. Neural Plast. 2012;2012:976164. |
22919518 |
Leuner K, Li W, Amaral MD, Rudolph S, Calfa G, Schuwald AM, Harteneck C, Inoue T, Pozzo-Miller L. Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels. Hippocampus. 2013 Jan;23(1):40-52. |
22815087 |
Amaral MD, Pozzo-Miller L. Intracellular Ca2+ stores and Ca2+ influx are both required for BDNF to rapidly increase quantal vesicular transmitter release. Neural Plast. 2012;2012:203536. |
22811938 |
Hartmann D, Drummond J, Handberg E, Ewell S, Pozzo-Miller L. Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders. Neural Plast. 2012;2012:203734. |
22720171 |
Chapleau CA, Pozzo-Miller L. Divergent roles of p75NTR and Trk receptors in BDNF's effects on dendritic spine density and morphology. Neural Plast. 2012;2012:578057. |
22548193 |
Li W, Pozzo-Miller L. Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice. Autism Open Access. 2012;2012(Suppl 1):5 |
23946910 |
Calfa G, Chapleau CA, Campbell S, Inoue T, Morse SJ, Lubin FD, Pozzo-Miller L. HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. Hippocampus. 2012 Jul;22(7):1493-500. |
22161912 |
Calfa G, Hablitz JJ, Pozzo-Miller L. Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging. J Neurophysiol. 2011 Apr;105(4):1768-84. |
21307327 |
Calfa G, Percy AK, Pozzo-Miller L. Experimental models of Rett syndrome based on Mecp2 dysfunction. Exp Biol Med (Maywood). 2011 Jan;236(1):3-19. |
21239731 |
Li Y, Calfa G, Inoue T, Amaral MD, Pozzo-Miller L. Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons. J Neurophysiol. 2010 May;103(5):2846-56. |
20220070 |
Chapleau CA, Calfa GD, Lane MC, Albertson AJ, Larimore JL, Kudo S, Armstrong DL, Percy AK, Pozzo-Miller L. Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations. Neurobiol Dis. 2009 Aug;35(2):219-33. |
19442733 |
Larimore JL, Chapleau CA, Kudo S, Theibert A, Percy AK, Pozzo-Miller L. Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations. Neurobiol Dis. 2009 May;34(2):199-211. |
19217433 |
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