Course Catalog

 
STP2356 PHARMACOGENOMICS - CLINICAL FOCUS
Department PHARMACOLOGY Campus Birmingham
Course Type(s) Special Topic Facility UAB Medical Center
Course Director Pius Fasinu, PhD Enrollment Limit 99
Contact Pius Fasinu, PhD Enrollment Minimum 2
Email pfasinu@uab.edu Address VH 240
Phone (205) 934-4565 Fax
Weeks
Normally Offered
See Offering Dates		 52-52
Prerequisites RISING MS2 ONLY 
Specific Clerkship Prerequisites:
Visiting Students
No LCME students accepted.
No osteopathic students accepted.
Course Description Pharmacogenomics, which is the study of how genetic variation impacts drug response, including adverse drug reactions and poor therapeutic outcomes, is a driver of personalized medicine. This discipline, which merges pharmacology with genomic technology, is transforming the development and prescription of medicines by identifying drug-relevant genetic variations. Clinicians will be at the forefront of this transformation to a more individualized, 'personalized' approach to drug therapy. This course provides updated contents on pharmacogenomics as it applies to clinical practice in various specialties including cardiology, neuropsychiatry, oncology and toxicology. It provides an overview of the available resources that clinicians rely on in practice, and it also addresses the legal, social and ethical considerations in clinical pharmacogenomics. Learning Objectives: 1. Describe how genetic variation in drug metabolizing enzymes may influence total drug exposure and pharmacokinetic parameters 2. Highlight important drug targets that have shown genetic polymorphism and are known to influence patient response to drug therapy 3. Provide examples of drugs which require pharmacogenetic testing before prescribing 4. Interprete standard pharmacogenetic test results 5. Discuss the legal, social and ethical considerations applicable to the clinical application of genetic-based pharmacotherapy
Where To Report Volker Hall 254, 9:00AM
Requirements 1. Attend all classes
2. Participate in assigned group work (to be turned in)
3. Make written and/or oral presentations on assigned topic
Evaluation End-of-course quiz - 50%
Participation in class/group work - 20%
Oral/written presentation - 30%
Notes Day 1 - Pharmacogenomics concepts, Personalized Medicine, Resources (PharmGKB, CPIC), FDA guidelines; levels of evidence
Day 2 - Pharmacogenomics in cardiology - Focus on Statins (SLCO1B1); antiplatelet therapy (Clopidogrel/prasugrel/ vs CYP2C19;)
Anticoagulant Therapy (Warfarin CYP2C9 and VCORC1; Dosing using CPIC guidelines and pharmacogenomic nomograms
Day 3 - Pharmacogenomics in Neurology/psychiatry - Focus on CNS drugs (antidepressants and CPY2D/ CYP2C19 polymorphism); Codeine and other opioids vs CYP2D
Day 4 - Pharmacogenomics in Oncology and Toxicology - UGT1A1 & irinotecan; DPYD & fluoropyrimidine; TPMT/ NUDT15 & mercaptopurine; TPMT & cisplatin; CYP2D6 & tamoxifen; HLA-B complex and drug toxicity (abacavir, carbamazepine, oxcarbazepine, phenytoin)
Day 5 - Personalized Medicine – From the Bench to the Bedside: Pharmacogenomic testing overview; Interpretation of PGx - test results – when to use result to guide prescribing; Legal, social, and ethical issues in PGx-based therapy; Case studies