Biochemistry and Structural Biology  http://www.gbs.uab.edu  http://www.uab.edu/graduate

Last Name First Name Research/Clinical Interest Title Keywords   BJORNSTI MARY-ANN DNA topoisomerase I, yeast genetics, cancer chemotherapeutics, TOR signaling, SUMOylation, DNA damage response, drug resistance, siRNA screening, breast cancer   YOUNG MARTIN   HIGGINS N   RENFROW MATTHEW Analysis of Protein Glycosylation in Human Disease by High Resolution Mass Spectrometry Fourier transform mass spectrometry (FT-MS), protein glycosylation, IgA O-glycosylation, IgA nephropathy, proteomics, glycoproteomics   PLACZEK WILLIAM Anti-cancer target validation and structure-based drug discovery. NMR spectroscopy, cancer, drug discovery, peptide synthesis, structural biology, apoptosis, signaling   PITTLER STEVEN Basic and Translational Studies of Photoreceptor Metabolism and Retinal Degeneration retinitis pigmentosa, phosphodiesterase, cGMP-gated cation channel, photoreceptor, phototransduction   SCHNEIDER DAVID Control of RNA polymerase I transcription cancer, gene expression, RNA processing, ribosomes, transcription, drug development, enzymology   ROWE STEVEN Cystic Fibrosis Clinical and Translational Research cystic fibrosis, CFTR, nonsense mutations   TOWNES TIM Developmental Regulation of Gene Expression   KEDISHVILI NATALIA Discovery and characterization of novel enzymes that regulate the conversion of vitamin A to bioactive retinoic acid vitamin A, retinoic acid, oxidoreductases, development, differentiation   CHESNOKOV IGOR DNA Replication and Cell Cycle in Eukaryotes DNA replication, cytokinesis, Origin Recognition Complex   LU RUI Epigenetic Mechanisms in Cancer Initiation, Maintenance, and Drug Resistance Cancer, Leukemia, Epigenetics, Genomics, Chromatin, Gene regulation, Novel therapeutics   HARTMAN JOHN Experimental models of gene interaction networks that buffer human disease using cell array phenotyping of yeast gene knockout libraries yeast genetics, quantitative high throughput cell array phenotyping (Q-HTCP), gene interaction networks, cellular quiescence, aging, cystic fibrosis, chemotherapy response, systems biology, drug discovery, lab automation   HABEGGER KIRK FGF21 as mediator of the metabolic actions of glucagon & Duodenal nutrient exclusion enhances glucose metabolism via CNS regulation   HASSAN QUAMARUL Gene Regulation by Non-coding RNA, Chromatin Remodeling and Modifications MicroRNA, Epigenetics, Bone, Tooth, Osteoblast Gene Expression, Odontoblast Gene Regulation   HIGGINS N Genetic and Biochemical Studies of Chromosome Dynamics Topoisomerases, Transposition, Site-specific Recombination, Genetics   WENDE ADAM Glucose-mediated remodeling of cardiac DNA methylation Diabetes, Hypertension, Exercise, Mitochondria, Metabolism, Glucose, Epigenetics, Gene expression, transcription, O-GlcNAc, protein modifications, DNA methylation, Histone modification, GLUT4, PDK2, PDK4   GROSS ALECIA GPCR trafficking in neurons and rhodopsin-mediated retinal degenerations rhodopsin, autosomal dominant retinitis pigmentosa, GPCR trafficking, rab11, nudC, MKS proteins, NPHP proteins, BBS proteins, retinal degeneration, inflammatory response in retina, cilia, protein trafficking   FRANK STUART Growth Hormone Action and GH Receptor Structure and Function growth hormone, signaling, prolactin, IGF-1, growth factors   KLUG CHRISTOPHER Hematopoietic stem cell biology, acute leukemia, and pancreatic cancer   CHOW LOUISE Human papillomavirus DNA replication and pathogenesis HPV infections and cancers   BHATNAGAR SUSHANT Identification and characterization of novel factors in insulin secretion in obesity and type 2 diabetes Obesity, Type 2 Diabetes, Beta Cell Biology, Insulin Secretion, SNARE Biology, Secreted Proteins, Insulin Granule Trafficking, Tomosyn Proteins, Post-translational Modifications   STRONG THERESA Identification of Tumor Antigens and Development of Cancer Vaccines gene therapy, immunotherapy, vaccine, Phase I clinical trials   SZTUL ELIZABETH Membrane Traffic; Protein Degradation Cystic fibrosis, membrane traffic, degradation, quality control   LEFKOWITZ ELLIOT Microbial Genomics and Evolution; Bioinformatics, and Clinical Informatics Viruses, Evolution, Genomics, Bioinformatics, Biomedical Informatics   PATEL RAKESH Modulation of Inflammation by Reactive Species and N-glycans vascular, hemoglobin, red cells, Inflammation, isoflavones, Nitric oxide, nitrite, N-glycan, matrikine   BRENNER MICHAEL Molecular Sudies of Astrocytes in Health and Disease astrocyte, GFAP, transcription, neurodegeneration, transgenic mice   NIEDERWEIS MICHAEL Novel proteins in the outer membrane of mycobacteria: Functions, structures, role in tuberculosis and applications tuberculosis, virulence, antibiotic resistance, membrane, proteins, transport, nanotechnology   NOVAK JAN Pathogenesis and treatments of chronic diseases, infectious diseases, cancer. IgA nephropathy. Mucosal immunology. Biomarkers.   AGARWAL ANUPAM Regulation of heme oxygenase gene expression in kidney and vascular injury heme oxygenase, acute kidney injury, transplant nephrology, lymphangiogenesis   BELLIS SUSAN Role of glycosylation in tumor progression and metastasis tumorigenesis, metastasis, cancer stem cell, cell invasion, apoptosis, tumor immunology,   RAMANADHAM SASANKA Role of Lipid Mediators in Signal Transduction Islets, signal transduction, iPLA2, bone, protease inhibitors   RYAN THOMAS Stem Cell Therapies in Animal Models of Human Disease Sickle cell anemia, thalassemia, embryonic stem cells, hemoglobin, mutagenesis, gene regulation   PETIT CHAD Strain Dependent Structure and Function of the Influenza NS1 Protein influenza, nmr, ns1, structural biology, virology   KRISHNA NEPALLI Structural Biology and Biomolecular NMR Spectroscopy Proteins, Structural Biology, NMR   VASSYLYEV DMITRY Structural studies of prokaryotic transcription   VAN WAARDENBURG ROBERT Structure-Function analysis of Tyrosyl-DNA phosphodieasterase I; Developing a DNA Repair Enzyme as Therapeutic Target for Anti-Cancer Treatment Structure-function analysis, Mechanism of Action of proteins and drugs (chemotherapeutics), Drug Development for novel therapeutic targets, Post-translational modification by Ubiquitin and SUMO (Small Ubiqitin like modifier), Protein interactions   SUDARSHAN SUNIL The Metabolic Basic of Kidney Cancer tumor metabolism, epigenetics, renal cancer   HUNTER CHAD Transcriptional control of pancreatic beta cell development and adult islet cell function Diabetes, Transcription Factor, Coregulators, Gene Regulation, Organogenesis, Pancreas, Chromatin, Developmental Biology, Endocrinology   THOMPSON SUNNIE Viral host pathogen interactions Host pathogen interactions, Mechanisms of viral translation, IRES, Polyomaviruses, Coronaviruses, Enteroviruses, Flaviviruses, Ribosome, Translational mechanisms in Cancer