Ji, M.H., Kim, S.K., Kim, C.Y., Phi, J.H., Jun, H.J., Blume, S.W., Choi, H.S. (2015) Physiological expression and accumulation of the products of two upstream open reading frames mrtl and MycHex1 along with p64 and p67 Myc from the human c-myc locus. J. Cell. Biochem. in press. |
26552949 |
Vaklavas, C., Meng, Z., Choi, H., Grizzle, W.E., Zinn, K.R., & Blume, S.W. (2015) Small molecule inhibitors of IRES-mediated translation. Cancer Biol. Ther. 16:1471-85. |
26177060 |
Meng, Z., Jackson, N.L., Shcherbakov, O.D., Choi, H., Blume, S.W. (2010) The human IGF1R IRES likely operates through a Shine-Dalgarno-like interaction with the G961 loop (E-site) of the 18S rRNA and is kinetically modulated by a naturally-polymorphic polyU loop. J. Cell. Biochem. 110: 531-44. |
20432247 |
Blume, S.W., Jackson, N.L., Frost, A.R., Grizzle, W.E., Shcherbakov, O.D, Choi, H., Meng, Z. (2010) Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES. Exp. Mol. Pathol. 88(3):341-52. |
20233590 |
Choi, H., Jackson, N.L., Shaw, D.R., Emanuel, P.D., Liu, Y. L., Tousson, A., Meng, Z., & Blume, S.W. (2008) mrtl – A translation / localization regulatory protein encoded within the human c-myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network. J. Cell. Biochem. 105: 1092-1108. |
18816594 |
Meng, Z., Jackson, N.L., Choi, H., King, P.H., Emanuel, P.D., & Blume, S.W. (2008) Alterations in RNA-binding activities of IRES-regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF-IR translational control in human breast tumor cells. J. Cell Physiol. 217: 172-83. |
18452152 |
Meng, Z., King, P.H., Nabors, L.B., Jackson, N.L., Chen, C-Y., Emanuel, P.D., & Blume, S.W. (2005) The ELAV RNA-stability factor HuR binds the 5’-untranslated region of the human IGF1R transcript and differentially represses cap-dependent and IRES-mediated translation. Nucleic Acids Res. 33: 2962-2979. |
15914670 |
Blume, S.W., Miller, D.M., Guarcello, V., Shrestha, K., Meng, Z., Snyder, R.C., Grizzle, W.E., Ruppert, J.M., Gartland, G.L., Stockard, C.R., Jones, D.E., & Emanuel, P.D. (2003) Inhibition of tumorigenicity by the 5’-untranslated RNA of the human c-myc P0 transcript. Exp. Cell Res. 288: 131-142. |
12878165 |
Meng, Z., Snyder, R.C., Shrestha, K., Miller, D.M., Emanuel, P.D., & Blume, S.W. (2003) Evidence for Differential Ribonucleoprotein Complex Assembly In Vitro on the 5'-Untranslated Region of the Human IGF-IR Transcript. Mol. Cell. Endocrinol. 200: 127-140. |
12644306 |
Blume, S.W., Meng, Z., Shrestha, K., Snyder, R.C., & Emanuel, P.D. (2003) The 5'-untranslated RNA of the human dhfr minor transcript alters transcription pre-initiation complex assembly at the major (core) promoter. J. Cell. Biochem. 88: 165-180. |
12461786 |
Kar, S.R., Lebowitz, J., Blume, S., Taylor, K.B., & Hall, L.M. (2001) SmtB-DNA and protein-protein interactions in the formation of the Cyanobacterial Metallothionein repression complex: Zn2+ does not dissociate the protein-DNA complex in vitro. Biochemistry 40: 13378-89. |
11683648 |
Blume, S.W., Lebowitz, J., Zacharias, W., Guarcello, V., Mayfield, C.A., Ebbinghaus, S.W., Bates, P., Jones, D.E. Jr., Trent, J., Vigneswaran, N., & Miller, D.M. (1999) The integral divalent cation within the intermolecular purine*purine.pyrimidine structure: A variable determinant of the potential for, and characteristics of the triple helical association. Nucleic Acids Res. 27: 695-702. |
9862999 |
Blume, S.W., Guarcello, V., Zacharias, W. & Miller, D.M. (1997) Divalent transition metal cations counteract potassium-induced quadruplex assembly of oligo(dG) sequences. Nucleic Acids Res. 25: 617-625. |
9016604 |
Blume, S.W., Snyder, R.C., Ray, R., Thomas, S., Koller, C.A., & Miller, D.M. (1991) Mithramycin inhibits Sp1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J. Clin. Invest. 88:1613-1621. |
1834700 |
Snyder, R.C., Ray, R., Blume, S.W., & Miller, D.M. (1991) Mithramycin blocks transcriptional initiation of the c-myc P1 and P2 promoters. Biochemistry 30: 4290-4297. |
1827033 |
Gee, J.E., Blume, S., Snyder, R.C., Ray, R., & Miller, D.M. (1992) Triplex formation prevents Sp1 binding to the dihydrofolate reductase promoter. J. Biol. Chem. 267: 11163-11167. |
1597451 |
Blume, S.W., Gee, J.E., Shrestha, K., & Miller, D.M. (1992) Triple helix formation by purine-rich oligonucleotides targeted to the human dihydrofolate reductase promoter. Nucleic Acids Res. 20: 1777-1784. |
1579471 |
Vaklavas, C., Grizzle, W.E., Choi, H., Meng, Z., Zinn, K.R., Shrestha, K., and Blume, S.W. (2016) IRES inhibition induces terminal differentiation and synchronized death in triple-negative breast cancer and glioblastoma cells. Tumor Biol. (in press) |
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