Red blood cell exosome hemoglobin content increases after cardiopulmonary bypass and mediates acute kidney injury in an animal model Pat B, Oh JY, Masjoan Juncos JX, Powell PC, Collawn JF, Patel RP, Dell'Italia LJ; Clinical Working Group. J Thorac Cardiovasc Surg . 2020 Dec 3;S0022-5223(20)33187-1. doi: 10.1016/j.jtcvs.2020.11.102. |
33451850 |
Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease Heidi M Schmidt 1, Katherine C Wood 2, Sara E Lewis 3, Scott A Hahn 2, Xena M Williams 3, Brenda McMahon 2, Jeffrey J Baust 2, Shuai Yuan 2, Timothy N Bachman 2, Yekai Wang 4 5, Joo-Yeun Oh 6, Samit Ghosh 2 7, Solomon F Ofori-Acquah 2 7 8, Jeffrey D Lebensburger 9, Rakesh P Patel 6 10, Jianhai Du 4 5, Dario A Vitturi 1 2, Eric E Kelley 3, Adam C Straub 1 2 Arterioscler Thromb Vasc Biol . 2020 Dec 3;ATVBAHA120315081 |
33267657 |
Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants Gentle SJ, Ahmed KA, Yi N, Morrow CD, Ambalavanan N, Lal CV, Patel RP. Redox Biol . 2021 Jan;38:101782 |
33166868 |
Damage to Red Blood Cells during Whole Blood Storage. Oh JY, Marques MB, Xu X, Li J, Genschmer K, Gaggar A, Jansen JO, Holcomb JB, Francois-Pittet J, Patel RP. J Trauma Acute Care Surg. 2020 Apr 14. doi: 10.1097/TA.0000000000002730. |
32301878 |
Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunction. Regal-McDonald K, Somarathna M, Lee T, Litovsky SH, Barnes J, Peretik JM, Traylor JG Jr, Orr AW, Patel RP. PLoS One. 2020 Mar 24;15(3):e0230358. doi: 10.1371/journal.pone.0230358 |
32208424 |
Hydrogen peroxide regulates endothelial surface N-glycoforms to control inflammatory monocyte rolling and adhesion. McDonald KR, Hernandez-Nichols AL, Barnes JW, Patel RP. Redox Biol. 2020 Mar 6:101498. doi: 10.1016/j.redox.2020.101498 |
32171755 |
Sweet and Sticky: Selective Recruitment of Monocyte Subsets by Endothelial N-Glycans. Regal-McDonald K, Patel RP. Am J Pathol. 2020 Feb 18. pii: S0002-9440(20)30084-5. doi: 10.1016/j.ajpath.2020.01.006. [Epub ahead of print] Review. |
32084367 |
Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. Ottolini M, Hong K, Cope EL, Daneva Z, DeLalio LJ, Sokolowski JD, Marziano C, Nguyen NY, Altschmied J, Haendeler J, Johnstone SR, Kalani MY, Park MS, Patel RP, Liedtke W, Isakson BE, Sonkusare SK. Circulation. 2020 Apr 21;141(16):1318-1333. doi: 10.1161/CIRCULATIONAHA.119.043385 |
32008372 |
Over-the-counter mouthwash use, nitric oxide and hypertension risk. Joshipura K, Muñoz-Torres F, Fernández-Santiago J, Patel RP, Lopez-Candales A. Blood Press. 2020 Apr;29(2):103-112. doi: 10.1080/08037051.2019.1680270 |
31709856 |
16. SOD2 acetylation and deacetylation: Another tale of Jekyll and Hyde in cancer. Hjelmeland AB, Patel RP. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23376-23378. doi: 10.1073/pnas.1916214116 |
31694886 |
High-mannose intercellular adhesion molecule-1 enhances CD16+ monocyte adhesion to the endothelium. Regal-McDonald K, Xu B, Barnes JW, Patel RP. Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1028-H1038. doi: 10.1152/ajpheart.00306.2019. Epub 2019 Aug 9. |
31398058 |
24. A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions. MohanKumar K, Namachivayam K, Song T, Jake Cha B, Slate A, Hendrickson JE, Pan H, Wickline SA, Oh JY, Patel RP, He L, Torres BA, Maheshwari A. Nat Commun. 2019 Aug 2;10(1):3494. doi: 10.1038/s41467-019-11199-5. |
31375667 |
Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents. Detterich JA, Liu H, Suriany S, Kato RM, Chalacheva P, Tedla B, Shah PM, Khoo MC, Wood JC, Coates TD, Milne GL, Oh JY, Patel RP, Forman HJ. Free Radic Biol Med. 2019 Sep;141:408-415. |
31279092 |
Characterizing red blood cell age exposure in massive transfusion therapy: the scalar age of blood index (SBI). DeSantis SM, Brown DW, Jones AR, Yamal JM, Pittet JF, Patel RP, Wade CE, Holcomb JB, Wang H; PROPPR Study Group. Transfusion. 2019 Aug;59(8):2699-2708 |
31050809 |
Sun CW, Yang J, Kleschyov A, Zhuge Z, Carlstrom M, Pernow J, Wajih N, Isbell TS, Oh JY, Cabrales P, Tsai A, Townes T, Kim-Shapiro DB, Patel RP*, Lundberg JO. (2019) Hemoglobin β93 Cysteine is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell. Circulation. In Press |
30905171 |
T. Graham, D. Peavey, T. Gray, R. Patel, H. Wang, JF. Pittet, J. Kerby, M. Marques (2017) Assuring Hospital Supply of Fresh Red Blood Cells for Critically Ill Patients. Transfusion. In Press DOI 10.1111/trf.14058 |
28425604 |
K Ahmed, A Nichols, J Honavar, MT Dransfield, S Matalon, RP Patel (2017) Measuring nitrate reductase activity from human and rodent tongues Nitric oxide Jun 1;66:62-70 |
28390999 |
Shuai Yuan, Rakesh P Patel*, Christopher G Kevil* (2014) Working with nitric oxide and hydrogen sulfide in biological systems AJP Lung Cell Mol Physiol (2015); 308: L403 *Co-senior authors |
25550314 |
Victoria Harper, Joo-Yeun Oh, Ryan Stapley Marisa Marques, Landon Wilson, Stephen Barnes, Chiao-Wang Sun, Tim Townes, Rakesh P. Patel (2015). Peroxiredoxin-2 cycling is inhibited during erythrocyte storage. Antioxidant Redox Signaling 22: 294 |
25264713 |
Jaideep Honavar, Eddie Bradley, Kelley Bradley, Joo Yeun Oh, Matthew O Vallejo, Eric E. Kelley, Nadiezhda Cantu-Medellin, Stephen Doran, Louis J. Dell’italia, Sadis Matalon, Rakesh P. Patel (2014) Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature. Toxicology 321: 96 |
24769334 |
John D Lang Jr, Alvin B Smith, Angela Brandon, Kelley M Bradley, Yuliang Liu,D. Ralph Crowe, Nirag Jhala, Richard C Cross, Luc Frenette, Kenneth Martay, Youri Vater1, Alexander Vitin, Gregory Dembo, Derek DuBay, J Steven Bynon, Jeff M. Szychowski, Jorge Reyes, Jeffrey Halldorson, Stephen Rayhill, Andre Dick, Ramasamy Bakthavatsalam, Jo Ann Broeckel-Elrod1, Laura Sisson-Roberts, Terry Jordan, Lucinda Chen, Arunotai Siriussawakul, Devin E Eckhoff and Rakesh P. Patel (2014) Inhaled Nitric Oxide Administered Preemptively Improves Allograft Function and Decreases Post-operative Complications in Human Liver Transplantation PLOS One 9, e86053 |
24533048 |
Vitturi DA, Sun CW, Harper VM, Thrash-Williams B, Cantu-Medellin N, Chacko BK, Peng N, Dai Y, Wyss JM, Townes T, Patel RP (2012) Free Rad Biol Med Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo. [Epub ahead of print]
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23159546 |
El-Ferzli GT, Dreher M, Patel RP, Ambalavanan N.(2012) ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure. PLos One 7(9) |
22984626 |
Samal AA, Honavar J, Brandon A, Bradley KM, Doran S, Liu Y, Dunaway C, Steele C, Postlethwait EM, Squadrito GL, Fanucchi MV, Matalon S, Patel RP.(2012) Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality. Free Rad Biol Med 53(7):1431-9 |
22917977 |
Scott DW, Chen J, Chacko BK, Traylor JG Jr, Orr AW, Patel RP.(2012). Role of endothelial N-glycan mannose residues in monocyte recruitment during atherogenesis. ATVB 32(8) Epub Ahead of print |
22723438 |
Stapley R, Owusu BY, Brandon A, Cusick M, Rodriguez C, Marques MB, Kerby JD, Barnum SR, Weinberg JA, Lancaster JR Jr, Patel RP. (2012) Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity.Biochem J. 446(3);499-508 |
22720637 |
Owusu BY, Stapley R, Patel RP.(2012)Nitric oxide formation versus scavenging: the red blood cell balancing act. J. Physiol. 590(Pt20):4993-5000
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22687616 |
Greenway FL, Predmore BL, Flanagan DR, Giordano T, Qiu Y, Brandon A, Lefer DJ, Patel RP, Kevil CG.(2012)Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients.Diabetes Technol Ther. 2012 Jul;14(7):552-60
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22468627 |
Christopher G Kevil and Rakesh P Patel (2010) S-nitrosothiol biology and Therapeutic potential in metabolic disease. Current Opinion in Investigational Drugs. 10: 1127-34 |
20872315 |
T. Scott Isbell, Chiao-Wang Sun, Li-Chen Wu, Xinjun Teng, Dario A. Vitturi, Billy G Branch, Christopher G Kevi, Namasivayam Ambalavanan Lisa Schwiebert, Jinxiang Ren, Kevin M. Pawlik, Matthew B. Renfrow, Rakesh P. Patel*, Tim M. Townes*. (2008) Role of SNO-Hemoglobin in Normal Development and Physiology. Nature Medicine 14(7); 773 * Co-senior author |
18516054 |
Bennavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A. 2007. 104; 17977-82 |
17951430 |
Kelpke SS, Chen B, Bradley KM, Teng X, Chumley P, Moore B, Head H, Viera L, Thompson JA, Crossman DK, Bray MS, Eckhoff DE, Agarwal A, Patel RP (2012). Sodium nitrite therapy protects against brain death induced kidney injury and improves post-transplantation function. Kidney International. 82(3):304-13 |
17947960 |
John D Lang Jr, Xinjun Teng, Phillip Chumley, Jack H Crawford, T. Scott Isbell, Balu K Chacko, Yuliang Liu, Nirag Jhala, D. Ralph Crowe, Alvin B Smith, Richard C Cross, Luc Frenette, Mike Fallon , Eric E Kelley, Diana W Wilhite, Cheryl R Hall, Grier P Page, J Steven Bynon, Devin E Eckhoff and Rakesh P. Patel (2007) Preemptive Administration of Inhaled Nitric Oxide Accelerates Restoration of Liver Function in Adults Following Orthotopic Liver Transplantation. J Clin Inv. 4;117(9):2583-2591 |
17717604 |
Chacko BK, Scott DW, Chandler RT, Patel RP (2011). Endothelial surface N-glycans mediate leukocyte adhesion and are targets for the anti-inflammatory effects of PPAR ligands. J Biol. Chem. 286(44):38738-47 |
17237310 |
Jack H Crawford, James Huang, T. Scott Isbell, Sruti Shiva, Balu K Chacko, Alan Schechter, Victor M Darley-Usmar, Jeffrey D Kerby, John D Lang Jr, David Krauss, Chien Ho, Mark T Gladwin, Rakesh P Patel (2006) Hypoxia, Red Blood Cells and Nitrite Regulate NO-dependent Hypoxic Vasodilatation. Blood 107, 566-574 |
16195332 |
Joo-Yeun Oh, Jennifer Hamm, Xin Xu, Kristopher Genschmer, Ming Zhong, Jeffrey Lebensburger, Marisa B. Marques, Jeffrey D. Kerby, Jean-Francois-Pittet, Amit Gaggar, Rakesh P. Patel (2016). Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices Redox Biol. 167-177. doi: 10.1016/j.redox.2016.08.003. PMCID: PMC5007433 |
5007433 |
David A. Ford, Jaideep Honavar, Carolyn J. Albert, Mark A Duerr, Joo Yeun Oh, Stephen Doran, Sadis Matalon, Rakesh P. Patel (2016) Formation of chlorinated lipids post-chlorine gas exposure. J. Lip Research 57(8): 1529-40 PMCID:PMC4959868 |
4959868 |
Y Oh, R Stapley, V Harper, M Marques, RP Patel (2015) Predicting storage-dependent damage to Red Blood Cells using nitrite oxidation kinetics, Peroxiredoxin-2 oxidation and hemoglobin / free heme measurements. Transfusion 12; 2967-78 PMCID: PMC4715702 |
4715702 |
R Stapley, C Rodriguez, JY Oh, A Brandon, BM Wagener, MB Marques, JA Weinberg, JD Kerby, JF Pittet, RP Patel (2015) RBC Washing, nitrite therapy, and anti-heme therapies prevent stored RBC toxicity after trauma-hemorrhage. Free Rad Biol. Med. 85:207-218 PMCID: PMC4508223 |
4508223 |
D. Vitturi, X Teng, JC Toledo, S Matalon, JR Lancaster Jr, RP Patel (2009) Effects of Hemoglobin Fractional Saturation on Nitrite transport in Red Blood Cells: Evidence for Hypoxic Regulation of Nitrite Export. Am J Physiol In Press |
2685350 |
Cantu-Medellin N, Vitturi DA, Rodriguez C, Murphy S, Dorman S, Shiva S, Zhou Y, Jia Y, Palmer AF, Patel RP (2011). Effects of T-state and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling. Nitric Oxide: Biology and Chemistry. In Press |
2396555 |
C. Rodriguez, D. Vitturi, J He, M Vandromme, A Brandon, A Hutchings, LW Rue III, JD Kerby, RP Patel (2009) Sodium nitrite therapy attenuates hypertensive effects of HBOC-201 via a nitrite-reductase activity. Biochem J 422(3), 423-432 |
150230 |
Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures. Margaroli C, Benson P, Sharma NS, Madison MC, Robison SW, Arora N, Ton K, Liang Y, Zhang L, Patel RP, Gaggar A. Cell Rep Med. 2021 Apr 20;2(4):100242. doi: 10.1016/j.xcrm.2021.100242. Epub 2021 Mar 23. |
PMID: 33778787 |
A mechanism for matrikine regulation in acute inflammatory lung injury. Robison SW, Li J, Viera L, Blackburn JP, Patel RP, Blalock JE, Gaggar A, Xu X. JCI Insight. 2021 Apr 8;6(7):e140750. doi: 10.1172/jci.insight.140750. |
PMID: 33830084 |
Human and rodent red blood cells do not demonstrate xanthine oxidase activity or XO-catalyzed nitrite reduction to NO. Lewis SE, Rosencrance CB, De Vallance E, Giromini A, Williams XM, Oh JY, Schmidt H, Straub AC, Chantler PD, Patel RP, Kelley EE. Free Radic Biol Med. 2021 Oct;174:84-88. doi: 10.1016/j.freeradbiomed.2021.07.012. Epub 2021 Jul 15. |
PMID: 34273539 |
Safety and toxicology assessment of sodium nitrite administered by intramuscular injection. Miller L, Hébert CD, Grimes SD, Toomey JS, Oh JY, Rose JJ, Patel RP. Toxicol Appl Pharmacol. 2021 Oct 15;429:115702. doi: 10.1016/j.taap.2021.115702. Epub 2021 Aug 28. |
PMID: 34464673 |
Supplemental nitrite increases choroidal neovascularization in mice. Qi X, Ricart K, Ahmed KA, Patel RP*, Boulton ME*. Nitric Oxide. 2021 Dec 1;117:7-15. doi: 10.1016/j.niox.2021.09.005. Epub 2021 Sep 16. *Co-Senior Author |
PMID: 34537345 |
Potential role for age as a modulator of oral nitrate reductase activity Khandaker Ahtesham Ahmed 1, Kiyoung Kim 2, Karina Ricart 1, William Van Der Pol 3, Xiaoping Qi 4, Marcas M Bamman 5, Christian Behrens 6, Gordon Fisher 7, Michael E Boulton 4, Casey Morrow 5, Pamela V O'Neal 8, Rakesh P Patel 9 Nitric Oxide . 2021 Mar 1;108:1-7. doi: 10.1016/j.niox.2020.12.001. |
PMID: 33321206 |
Phosgene inhalation causes hemolysis and acute lung injury. Aggarwal S, Jilling T, Doran S, Ahmad I, Eagen JE, Gu S, Gillespie M, Albert CJ, Ford D, Oh JY, Patel RP, Matalon S. Toxicol Lett. 2019 Sep 15;312:204-213 |
PMID: 31047999 |
Joo-Yeun Oh, Austin Williams, Rakesh P. Patel (2019) Role of Redox-dependent mechanisms in heme release from hemoglobin and erythrocyte hemolysates Arch. Biochem. Biophys. 15; 662: 111-120 |
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