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Faculty Detail    
Name SHI WEI
MD, PhD
 
Campus Address HSB 138
Phone
E-mail  swei@uabmc.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Womens Health  Womens Health Professor

Graduate Biomedical Sciences Affiliations
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Wei obtained his M.D. from China Medical University (Shenyang, China) and received his Ph.D. from Okayama University in Japan. He completed a post-doctoral fellowship at Washington University School of Medicine (St. Louis, Missouri) prior to coming to UAB, where he finished his pathology residency followed by a surgical pathology fellowship. He obtained additional clinical subspecialty training at Emory, Mt. Sinai and Harvard Universities. Dr. Wei is board certified in Anatomic and Clinical Pathology. He joined the faculty at UAB in July, 2008 and is currently a Tenured Professor. Dr. Wei is currently Associate Division Director of Anatomic Pathology and heads the Surgical Pathology Section.

Society Memberships
Organization Name Position Held Org Link
American Medical Association  Member  http://www.ama-assn.org 
American Society of Clinical Pathology  Fellow  http://ascp.org 
Arthur Purdy Stout Society  Member  http://www.apssociety.com/ 
Association of Directors of Anatomic and Surgical Pathology  Member  http://www.adasp.org 
Chinese American Pathologists Association  Member  https://www.capa-ht.org/ 
College of American Pathologists  Alabama Delegate, CAP House of Delegates  http://www.cap.org 
Digital Pathology Association  Member  https://digitalpathologyassociation.org/ 
International Skeletal Society  Member  http://www.internationalskeletalsociety.com 
International Society of Bone and Soft Tissue Pathology  Member  http://www.isbstp.org 
International Society of Breast Pathology  Member  https://isbpath.org/ 



Research/Clinical Interest
Title
Description
Dr. Wei is actively engaged in the diagnostic surgical pathology service and has special interests in breast, muskuloskeletal and genitourinary pathology. His major research interests include discovery and evaluation of biomarkers in breast cancer and other malignancies, evaluation of prognostic factors in breast cancer and malignant bone tumors, and tumor bone metastasis. He has published more than 130 manuscripts in these areas in some of the leading peer-reviewed journals, of which he first- or senior-authored approximately two-thirds. Dr. Wei is a Scientist at UAB Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center and a Senior Scientist at UAB Comprehensive Cancer Center, Experimental Therapeutics Program.

Selected Publications 
Publication PUBMEDID
Aldrees R, Gao X, Zhang K, Siegal GP, Wei S. Validation of the Revised 8th AJCC Breast Cancer Clinical Prognostic Staging System: Analysis of 5321 Cases from a Single Institution. Mod Pathol 2020 Aug 10. doi: 10.1038/s41379-020-00650-4. Online ahead of print.   32778677 
Memon RA, Granada Prieto C, Wei S. Clear cell papillary neoplasm of the breast with MAML2 gene rearrangement: clear cell hidradenoma or low-grade mucoepidermoid carcinoma? Pathol Res Pract. In Press.   
I-SPY2 Trial Consortium; Douglas Yee, Angela M DeMichele, Christina Yau, Claudine Isaacs, W Fraser Symmans, Kathy S Albain, Yunn-Yi Chen, Gregor Krings, Shi Wei, Shuko Harada, Brian Datnow, Oluwole Fadare, Molly Klein, Stefan Pambuccian, Beiyun Chen, Kathi Adamson, Sharon Sams, Paulette Mhawech-Fauceglia, Anthony Magliocco, Mike Feldman, Mara Rendi, Husain Sattar, Jay Zeck, Idris T Ocal, Ossama Tawfik, Lauren Grasso LeBeau, Sunati Sahoo, Tuyethoa Vinh, A Jo Chien, Andres Forero-Torres, Erica Stringer-Reasor, Anne M Wallace, Lajos Pusztai, Judy C Boughey, Erin D Ellis, Anthony D Elias, Janice Lu, Julie E Lang, Hyo S Han, Amy S Clark, Rita Nanda, Donald W Northfelt, Qamar J Khan, Rebecca K Viscusi, David M Euhus, Kirsten K Edmiston, Stephen Y Chui, Kathleen Kemmer, John W Park, Minetta C Liu, Olufunmilayo Olopade, Brian Leyland-Jones, Debasish Tripathy, Stacy L Moulder, Hope S Rugo, Richard Schwab, Shelly Lo, Teresa Helsten, Heather Beckwith, Patricia Haugen, Nola M Hylton, Laura J Van't Veer, Jane Perlmutter, Michelle E Melisko, Amy Wilson, Garry Peterson, Adam L Asare, Meredith B Buxton, Melissa Paoloni, Julia L Clennell, Gillian L Hirst, Ruby Singhrao, Katherine Steeg, Jeffrey B Matthews, Smita M Asare, Ashish Sanil, Scott M Berry, Laura J Esserman, Donald A Berry. Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial. JAMA Oncol. 2020 Jul 23. doi: 10.1001/jamaoncol.2020.2535. Online ahead of print.   32701140 
Ayre K , Olariu E , Wei S, Molony E, Boggs D, Stringer Reasor E. Metastatic, Triple-Negative, Androgen Receptor-Positive, Invasive Lobular Carcinoma of the Breast: A Case Report. Clinics in Oncology. 2019 (4) Article 1669. http://www.clinicsinoncology.com/pdfs_folder/cio-v4-id1669.pdf   
Xu J, Hussain S, Wei S, Bao W, Zhang L. Associations of stay-at-home order and face-masking recommendation with trends in daily new cases and deaths of laboratory-confirmed COVID-19 in the United States. medRxiv. 2020 Jun 29;2020.05.01.20088237. doi: 10.1101/2020.05.01.20088237.   32637967 
Chen R, Qarmali M, Siegal GP, Wei S. Receptor Conversion in Metastatic Breast Cancer: Analysis of 390 Cases from a Single Institution. Mod Pathol 2020 Jul 3. doi: 10.1038/s41379-020-0615-z. Online ahead of print.   32620918 
Nam H , Kundu A, Brinkley GJ, Chandrashekar DS, Kirkman RL, Chakravarthi BVSK, Orlandella RM, Norian LA, Sonpavde G, Ghatalia P, Fei F, Wei S, Varambally S, Sudarshan S. PGC1α Suppresses Kidney Cancer Progression by Inhibiting Collagen-Induced SNAIL Expression. Matrix Biol. 2020 Jan 23;S0945-053X(20)30001-9. doi:10.1016/j.matbio.2020.01.001. Online ahead of print.  31982456 
Veazey G, Woodard SA, Wei S. Lactating adenoma. Radiological Society of North America Case Collection. DOI: 10.1148/cases.20201490.   
Wang K, Hackney JR. Siegal GP, Wei S. RANKLed by the Complexity of Signaling in Metastatic Breast Cancer to the Brain. Clin Breast Cancer. Clin Breast Cancer. 2020 Apr 11. pii: S1526-8209(20)30071-9. doi: 10.1016/j.clbc.2020.04.001. [Epub ahead of print]  32381383 
Rodriguez Pena MDC, Gordetsky J, Greipp PT, Wei S, Martignoni G, Netto GJ, Harada S, Prieto Granada CN. Rare MDM2 amplification in a fat-predominan angiomyolipoma. Virchows Arch. 2020 May 15. doi: 10.1007/s00428-020-02813-9. [Epub ahead of print]  32409886 
Reisenbichler ES, Han G, Bellizzi A, Bossuyt V, Brock J, Cole K, Fadare O, Hameed O, Hanley K, Harrison BT, Kuba MG, Ly A, Miller D, Podoll M, Roden AC, Singh K, Sanders MA, Wei S, Wen H, Pelekanou V, Yaghoobi V, Ahmed F, Pusztai L, Rimm DL. Prospective multi-institutional evaluation of pathologist assessment of PD-1 assays for patient selection in triple negative breast cancer. Mod Pathol. 2020 Apr 16. doi: 10.1038/s41379-020-0544-x. [Epub ahead of print]   32300181 
Kundu A, Nam H, Shelar S, Chandrashekar DS, Brinkley G, Karki S, Mitchell T, Livi CB, Buckhaults P, Kirkman R, Tang Y, Rowe GC, Wei S, Varambally S, Sudarshan S. PRDM16 suppresses HIF-targeted gene expression in kidney cancer. J Exp Med. 2020 Jun 1;217(6). pii: e20191005. doi: 10.1084/jem.20191005.  32251515 
Liu W, Zhang Y, Wei S, Bae S, Yang WH, Smith GJ, Mohler JL, Fontham ETH, Bensen JT, Sonpavde GP, Chen GY, Liu R, Wang L. A CD24-p53 axis contributes to African American prostate cancer disparities. Prostate. 2020 Mar 13. doi: 10.1002/pros.23973. [Epub ahead of print].   32168400 
Nam H, Kundu A, Brinkley GJ, Chandrashekar DS, Kirkman RL, Chakravarthi BVSK, Orlandella RM, Norian LA, Sonpavde G, Ghatalia P, Fei F, Wei S, Varambally S, Sudarshan S. PGC1α suppresses kidney cancer progression by inhibiting collagen-induced SNAIL expression. Matrix Biol. 2020 Jan 23. pii: S0945-053X(20)30001-9. doi: 10.1016/j.matbio.2020.01.001. [Epub ahead of print]   31982456 
Zheng L, Abdelgawwad MS, Zhang D, Xu M, Wei S, Cao W, Zheng XL. Histone-induced thrombotic thrombocytopenic purpura in adamts13-/- zebrafish depends on von Willebrand factor. Haematologica. 2019 Nov 21. pii: haematol.2019.237396. doi: 10.3324/haematol.2019.237396. [Epub ahead of print]  31753928 
Mruthyunjayappa S, Zhang K, Zhang L, Eltoum IA, Siegal GP, Wei S. Synchronous and Metachronous Bilateral Breast Cancer: Clinicopathologic Characteristics and Prognostic Outcomes. Hum Pathol. 2019 Oct;92:1-9. doi: 10.1016/j.humpath.2019.07.008. Epub 2019 Jul 24.  31351153 
Peker D*, Wei S*, Siegal GP. Bone Pathology for Hematopathologists. Surg Pathol Clin. 2019 Sep;12(3):831-847. doi: 10.1016/j.path.2019.03.007. Epub 2019 May 22. *Contributed equally.  31352990 
Wang K, Guo R, Siegal GP, Wei S. Inflammatory Myofibroblastic Tumor of Bone Harboring an ALK Amplification. Pathol Res Pract. 2019 Jul 13:152535. doi: 10.1016/j.prp.2019.152535. [Epub ahead of print].   31326196 
116. Li M, Liu J, Li S, Feng Y, Yi F, Wang L, Wei S,* Cao L.* Autophagy related 7 modulates tumor progression in triple-negative breast cancer. Lab Invest. 2019 Apr 15. doi: 10.1038/s41374-019-0249-2. [Epub ahead of print] *Co-corresponding authors.  30988371 
Wu L, Yi B, Wei S, Yao D, He Y, Naik G, Bae S, Liu XM, Yang WH, Sonpavde G, Liu R, Wang L. Loss of Foxp3 and Tsc1 Accelerate Prostate Cancer Progression through a Synergistic Transcriptional and Post-translational Regulation of c-MYC. Cancer Res. 2019 Feb 7. pii: canres.2049.2018. doi: 10.1158/0008-5472.CAN-18-2049. [Epub ahead of print]   30733194 
Yang Y, Wang HX, Zhang L, Huo W, Li XD, Qi RQ, Song XY, Wei S, Gao XH, Han S, Cao L. Inhibition of Heme Oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect. Int J Biol Sci. 2019 Jan 1;15(3):568-578. doi: 10.7150/ijbs.29759. eCollection 2019.   30745843 
Fasciano D, Wei S, Li R, Siegal GP. Chondroblastoma-like tumor of the skull in a patient with cardio-facio-cutaneous syndrome. Pathol Res Pract. 2018 Aug 7. pii: S0344-0338(18)30787-8. doi: 10.1016/j.prp.2018.08.003. [Epub ahead of print]   30100356 
Sharma NS, Lal CV, Li JD, Lou XY, Viera L, Abdallah T, King R, Sethi J, Kanagarajah P, Restrepo-Jaramillo R, Sales-Conniff A, Wei S, Jackson PL, Blalock JE, Gaggar A, Xu X. The Neutrophil Chemoattractant Peptide Proline-Glycine-Proline Is Associated With Acute Respiratory Distress Syndrome (ARDS). Am J Physiol Lung Cell Mol Physiol. 2018 Aug 9. doi: 10.1152/ajplung.00308.2017. [Epub ahead of print]   30091378 
Kurundkar A, Gao X, Zhang K, Britt JP, Siegal GP, Wei S. Comparison of AJCC Anatomic and Clinical Prognostic Stage Groups in Breast Cancer: Analysis of 3322 Cases From a Single Institution. Clin Breast Cancer. 2018 Jul 17. pii: S1526-8209(18)30230-1. doi: 10.1016/j.clbc.2018.07.013. [Epub ahead of print].   30077697 
Broadwater DR, Conant JL, Czuchlewski DR, Hall JM, Wei S, Siegal GP, Peker D. Clinicopathologic Features and Clinical Outcome Differences in De Novo Versus Secondary Histiocytic Sarcomas: A Multi-institutional Experience and Review of the Literature. Clin Lymphoma Myeloma Leuk. 2018 Aug 1. pii: S2152-2650(18)30371-9. doi: 10.1016/j.clml.2018.07.286. [Epub ahead of print]   30077697 
Zhang Y, Yi F, Wang L, Wang Z, Zhang N, Wang Z, Li Z, Song X, Wei S,* Cao L.* Phosphorylation of SMC1A promotes hepatocellular carcinoma cell proliferation and migration. Int J Biol Sci 2018; 14(9):1081-1089. doi:10.7150/ijbs.24692. *Co-corresponding authors.  29988990 
Wei S, Siegal GP. Surviving at a distant site: The organotropism of metastatic breast cancer. Semin Diagn Pathol. 2017 Nov 16. pii: S0740-2570(17)30135-1. doi: 10.1053/j.semdp.2017.11.008. [Epub ahead of print].  29174933 
Pruitt HC, Metge BJ, Weeks SE, Chen D, Wei S, Kesterson RA, Shevde LA, Samant RS. Conditional knockout of N-Myc and STAT Interactor Disrupts Normal Mammary Development and Enhances Metastatic Ability of Mammary Tumors. Oncogene. 2018 Jan 12. doi: 10.1038/s41388-017-0037-7. [Epub ahead of print]  29326438 
Shen T, Gao C, Zhang K, Siegal GP, Wei S. Prognostic Outcomes in Advanced Breast Cancer: The Metastasis-free Interval is Important. Hum Pathol. 2017 Oct 12. pii: S0046-8177(17)30361-1. doi: 10.1016/j.humpath.2017.10.002. [Epub ahead of print].  29031733  
Wang K, Shen T, Siegal GP, Wei S. The CD4/CD8 Ratio of Tumor-infiltrating Lymphocytes at the Tumor-host Interface Has Prognostic Value in Triple Negative Breast Cancer. Hum Pathol. 2017 Oct 6. pii: S0046-8177(17)30357-X. doi: 10.1016/j.humpath.2017.09.012. [Epub ahead of print].  28993275  
Lopez L, Rodriguez MG, Siegal GP, Wei S. Extraskeletal Aneurysmal Bone Cyst: Report of a Case and Review of the Literature. Pathol Res Pract. 2017 Nov;213(11):1445-1449. doi: 10.1016/j.prp.2017.07.001. Epub 2017 Jul 6. PMID: 28756986   28756986  
Zhu H, Sun J, Wei S, Wang D, Brandwein M. Well-Differentiated Laryngeal/Hypopharyngeal Liposarcoma in the MDM2 Era Report of Three Cases and Literature Review. Head Neck Pathol. 2017 Jun;11(2):146-151. doi: 10.1007/s12105-016-0747-0. Epub 2016 Aug 4.   27492446 
Li R, Zhang K, Siegal GP, Wei S. Clinical and pathological factors related to brain relapse-free survival in breast cancer patients-reply. Hum Pathol. 2017 Jun 24. pii: S0046-8177(17)30229-0. doi: 10.1016/j.humpath.2017.05.028. [Epub ahead of print]  28655640 
Zhou Y, Wei S. Not Your Typical Renal Cyst. Am J Med. 2017 Jul 4. pii: S0002-9343(17)30637-X. doi: 10.1016/j.amjmed.2017.06.006. [Epub ahead of print]  28687266 
Cui X, Wei S. Carcinoma in Situ Involving Sclerosing Adenosis: Seeking the Salient Histological Characteristics to Prevent Overdiagnosis. Ann Clin Lab Sci. 2017 Sep;47(5):529-534.  29066477 
Ullman D, Gordetsky J, Siegal GP, Prieto-Granada GN, Wei S, Stevens TM. PAX8 expression in solitary fibrous tumor: A potential diagnostic pitfall. Appl Immunohistochem Mol Morphol. 2017 Jul 26. doi: 10.1097/PAI.0000000000000561. [Epub ahead of print]  28749793  
Chen S, Fritchie K, Wei S, Ali N, Curless K, Shen T, Brini AT, Latif F, Sumathi V, Siegal GP, Cheng L. Diagnostic Utility of IDH1/2 Mutations to Distinguish Dedifferentiated Chondrosarcoma from Undifferentiated Pleomorphic Sarcoma of Bone. Hum Pathol. 2017 May 25. pii: S0046-8177(17)30172-7. doi: 10.1016/j.humpath.2017.05.015. [Epub ahead of print]  28552826 
Zhang G, Zhang W, Li B, Stringer-Reasor E, Chu C, Sun L, Bae S, Chen D, Wei S, Jiao K, Yang WH, Cui R, Liu R, Wang D. MicroRNA-200c and 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. Breast Cancer Res. 2017 Jun 21;19(1):73. doi: 10.1186/s13058-017-0858-x  28637482 
Li R, Zhang K, Siegal GP, Wei S. Clinicopathologic Factors Associated with Survival in Patients with Breast Cancer Brain Metastasis. Hum Pathol. 2017 Apr 17. pii: S0046-8177(17)30109-0. doi: 10.1016/j.humpath.2017.03.022. [Epub ahead of print]  28428107 
Tian W, Dorn D, Wei S, Shah RB, Sanders RD, Gordetsky J. GATA3 Expression in Benign Prostate Glands with Radiation Atypia: a Diagnostic Pitfall. Histopathology. Histopathology. 2017 Mar 17. doi: 10.1111/his.13214. [Epub ahead of print]  28316088  
Wei S, Qian X, Henderson-Jackson EB, Bui, M. Soft Tissue Tumor Immunohistochemistry Update: Illustrative Examples of Diagnostic Pearls to Avoid Pitfalls. Arch Pathol Lab Med. 2017 Aug;141(8):1072-1091. doi: 10.5858/arpa.2016-0417-RA.  28745570 
Wei S, Siegal GP. Metastatic Organotropism: An Intrinsic Property of Breast Cancer Molecular Subtypes. Adv Anat Pathol. 2017 Jan 16. doi: 10.1097/PAP.0000000000000140. [Epub ahead of print]  28098572  
Wielgos ME, Rajbhandari R, Cooper TS, Wei S, Nozell SE, Yang ES. Let-7 Status is Crucial for PARP1 Expression in HER2-overexpressing Breast Tumors. Mol Cancer Res. 2016 Dec 28. pii: molcanres.0287.2016. doi: 10.1158/1541-7786.MCR-16-0287-T. [Epub ahead of print]  28031413 
Ma Y, Siegal GP, Wei S. Reacquisition of E-cadherin Expression in Metastatic Deposits of Signet-Ring Cell Carcinoma of the Upper Gastrointestinal System: A Potential Anchor for Metastatic Deposition. J Clin Pathol. 2017 Jun;70(6):528-532. doi: 10.1136/jclinpath-2016-203959. Epub 2016 Nov 18.   27864451 
Soni A, Wei S. Primary Renal Ewing Sarcoma in an Adult. Urology. 2016 Oct 6. pii: S0090-4295(16)30652-5. doi: 10.1016/j.urology.2016.09.033. [Epub ahead of print]  27720971 
Shen T, Siegal GP, Wei S. Clinicopathologic Factors Associated with De Novo Metastatic Breast Cancer. Pathol Res Pract. 2016 Sep 22. pii: S0344-0338(16)30274-6. doi: 10.1016/j.prp.2016.09.007. [Epub ahead of print]  27692496 
Zhao J, Yu H, Liu Y, Gibson S, Yan Z, Xu X, Gaggar A, Li P-K, Li C, Wei S, Benveniste E, Qin H. Protective Effect of Suppressing STAT3 Activity in LPS-induced Acute Lung Injury. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L868-L880. doi: 10.1152/ajplung.00281.2016. Epub 2016 Sep 16.  27638904 
Weaver AN, Cooper TS, Wei S, Carroll WR, Rosenthal EL, Yang ES. DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery. Head Neck. 2016 Aug 10. doi: 10.1002/hed.24562. [Epub ahead of print]  27507640 
Ghatalia P, Yang ES, Lasseigne BN, Ramaker RC, Cooper SJ, Chen D, Sudarshan S, Wei S, Guru AS, Zhao A, Cooper T, Della Manna DL,Naik G, Myers RM, Sonpavde G. Kinase Gene Expression Profiling of Metastatic Clear Cell Renal Cell Carcinoma Tissue Identifies Potential NewTherapeutic Targets. PLoS One. 2016 Aug 30;11(8):e0160924. doi: 10.1371/journal.pone.0160924. eCollection 2016  27574806  
Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J, Symmans WF, Yee D, Chien AJ,Wallace AM, Kaplan HG, Boughey JC, Haddad TC, Albain KS, Liu MC, Isaacs C, Khan QJ, Lang JE, Viscusi RK, Pusztai L, Moulder SL, Chui SY, Kemmer KA, Elias AD, Edmiston KK, Euhus DM, Haley BB, Nanda R, Northfelt DW, Tripathy D, Wood WC, Ewing C, Schwab R, Lyandres J, Davis SE, Hirst GL, Sanil A, Berry DA, Esserman LJ; I-SPY 2 Investigators. Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer. N Engl J Med. 2016 Jul 7;375(1):23-34. doi: 10.1056/NEJMoa1513749.  27406347 

Keywords
Breast Pathology; Muskuloskeletal Pathology; Genitourinary Pathology